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001-es BibID:	BIBFORM080007
035-os BibID:	(WOS)000469410200026 (Scopus)85064828753
Első szerző:	Liu, Da-Hua
Cím:	Osteoclastogenesis Regulation Metabolites from the Coral-Associated Fungus Pseudallescheria boydii TW-1024-3 / Da-Hua Liu, Yi-Zhe Sun, Tibor Kurtán, Attila Mándi, Hua Tang, Jiao Li, Li Su, Chun-Lin Zhuang, Zhi-Yong Liu, Wen Zhang
Dátum:	2019
ISSN:	0163-3864 1520-6025
Megjegyzések:	Three new compounds (9-11) were isolated together with eight known analogues from the fungus Pseudallescheria boydii associated with the South China Sea soft coral Sinularia sandensis. The structures of the new compounds were elucidated on the basis of the spectroscopic analysis, and the absolute configurations including the sulfur stereogenic center of a sulfoxide moiety were determined by comparison of experimental ECD spectra to TDDFT/ECD calculations. Epimeric chiral sulfoxides differing in the absolute configuration of the sulfur chirality center could be efficiently distinguished and assigned by comparing the experimental ECD to those of calculations for the sulfur epimers. In the in vitro biotests for osteoclastogenesis effects, compounds 1, 5, 7, and 10 exhibited a stimulatory activity, while compound 3 displayed an inhibitory activity.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal of Natural Products. - 82 : 5 (2019), p. 1274-1282. -
További szerzők:	Sun, Yi-Zhe Kurtán Tibor (1973-) (vegyész, angol szakfordító) Mándi Attila (1981-) (vegyész, német szakfordító) Tang, Hua Li, Jiao Su, Li Zhuang, Chun-Lin Liu, Zhi-Yong Zhang, Wen
Pályázati támogatás:	NKFI K120181 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM071444
035-os BibID:	(WOS)000416500400010 (Scopus)85035064628
Első szerző:	Sun, Yi-Zhe
Cím:	Immunomodulatory Polyketides from a Phoma-like Fungus Isolated from a Soft Coral / Yi-Zhe Sun, Tibor Kurtán, Attila Mándi, Hua Tang, Yalan Chou, Keryea Soong, Li Su, Peng Sun, Chun-Lin Zhuang, Wen Zhang
Dátum:	2017
ISSN:	0163-3864
Megjegyzések:	Fourteen new polyketides with a trans-fused decalin ring system, libertalides AN (316), together with two known analogues, aspermytin A and its acetate (1, 2), were isolated from the fermentation extract of a coral-derived Libertasomyces sp. fungus. Their relative configurations were elucidated on the basis of detailed spectroscopic analysis, and the absolute configurations were determined by TDDFT-ECD and optical rotation (OR) calculations. The OR of 1 and 2 were found to have opposite signs in CH3CN and CHCl3, which was in agreement with the OR calculations producing alternating signs for the optical rotation depending on the applied conditions. Because the signs of the OR for 1 and 2 showed high solvent dependence, they may not be used alone to correlate the absolute configurations. Compound 16 displayed structural novelty characterized by an alpha-enol ether bridge conjugated with an aldehyde group. In in vitro immunomodulatory screening, compounds 1, 4, and 10 significantly induced the proliferation of CD3(+) T cells, while compounds 2, 7, 11, and 14 significantly increased the CD4(+)/CD8(+) ratio at 3 mu M. A preliminary structureactivity analysis revealed a crucial role of Delta(7) and a terminal OH group in the regulation of CD3(+) T cell proliferation. This is the first report of immunoregulatory activity for metabolites of this kind.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal of Natural Products. - 80 : 11 (2017), p. 2930-2940. -
További szerzők:	Kurtán Tibor (1973-) (vegyész, angol szakfordító) Mándi Attila (1981-) (vegyész, német szakfordító) Tang, Hua Chou, Yalan Soong, Keryea Su, Li Sun, Peng Zhuang, Chun-Lin Zhang, Wen
Pályázati támogatás:	NKFI K120181, PD121020 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: