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001-es BibID:	BIBFORM101811
035-os BibID:	(WOS)000736558700001 (Scopus)85122425195
Első szerző:	Huang, Sheng-Zhuo
Cím:	Hexahydroazulene-2(1H)-one Sesquiterpenoids with Bridged Cyclobutane, Oxetane, and Tetrahydrofuran Rings from the Stems of Daphne papyracea with α-Glycosidase Inhibitory Activity / Sheng-Zhuo Huang, Qi Wang, Jing-Zhe Yuan, Cai-Hong Cai, Hao Wang, Attila Mándi, Tibor Kurtán, Hao-Fu Dai*, and You-Xing Zhao
Dátum:	2022
ISSN:	0163-3864 1520-6025
Megjegyzések:	Chemical investigation of an alcoholic extract from the stem of Daphne papyracea ("Xuehuagou") led to the isolation of the tetracyclic sesquiterpenoid daphnepapytone A (1), containing a unique caged skeleton with a cyclobutane ring having three tetrasubstituted chirality centers. Also isolated were new guaiane sesquiterpenoids, namely, daphnepapytones B-H (2-8), and one 1,5-diphenylpentanone 2-hydroxy-5-oxo-daphneone (9), together with 26 known compounds. The cyclic metabolites share a 5-isoprenyl-hexahydroazulene-2(1H)-one skeleton with different substitution patterns and a bridged cyclobutane, oxetane, or tetrahydrofuran ring. The planar structures and relative configuration of the new compounds were elucidated on the basis of spectroscopic analysis aided by DFT C-13 NMR calculations. The absolute configurations of 1-7 were determined by X-ray single-crystal diffraction or TDDFT-ECD calculations. Daphnepapytones A and C (1 and 3), 2-hydroxy-5-oxodaphneone (9), daphnenone (10), daphneone (11), and 3-methyldaphneolone (12) showed alpha-glycosidase inhibitory activity, with IC50 values of 159.0, 102.3, 139.3, 43.3, 145.0, and 126.1 mu M, respectively.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal of Natural Products. - 85 : 1 (2022), p. 3-14. -
További szerzők:	Wang, Qi Yuan, Jing-Zhe Cai, Cai-Hong Wang, Hao Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Dai, Haofu Zhao, You-Xing
Pályázati támogatás:	GINOP-2.3.2-15-2016-00008 GINOP NKFI K120181 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM114612
035-os BibID:	(WoS)001026992900001 (Scopus)85165695315
Első szerző:	Wang, Lin
Cím:	Asperphenalenones Isolated from the Biocontrol Agent Clonostachys rosea and Their Antimicrobial Activities / Lin Wang, Anna-Lene Kiffe-Delf, Philipp Niklas Ostermann, Viktor Emanuel Simons, Di He, Ying Gao, Lasse van Geelen, Hao-Fu Dai, You-Xing Zhao, Heiner Schaal, Attila Mándi, Sándor Balázs Király, Tibor Kurtán, Zhen Liu, and Rainer Kalscheuer
Dátum:	2023
ISSN:	0021-8561
Megjegyzések:	Clonostachys rosea is a fungus widely distributed on Earth and has a high capacity to adapt to complex environments in soil, plants, or sea. It is an endophyte that can be used as a potential biocontrol agent to protect plants from pathogenic fungi, nematodes, and insects. However, the spectrum of secondary metabolites produced by C. rosea has only scarcely been studied. In the present study, eight new phenalenones, asperphenalenones F-M (1-8), together with two known derivatives, asperphenalenones E and B (9 and 10), were isolated from the axenic rice culture of this fungus. The structures of the new compounds were elucidated by nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, electronic circular dichroism, and gas chromatography-mass spectrometry analyses. Asperphenalenones J-M (5-8) are unusual phenalenone adducts that are conjugated to diterpenoid glycosides. Asperphenalenones F and H showed moderate antibacterial activity against methicillin-resistant Staphylococcus aureus, with minimal inhibitory concentrations of 12.5 and 25 ?M, respectively. Asperphenalenone B exhibited low antiviral activity against the human immunodeficiency virus replication. Furthermore, asperphenalenones F and H exhibited low cytotoxicity against Jurkat cells, while all other compounds were devoid of cytotoxicity.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Clonostachys rosea asperphenalenones antibacterial activity methicillin-resistant Staphylococcus aureus (MRSA) anti-HIV activity
Megjelenés:	Journal of Agricultural and Food Chemistry. - 71 : 29 (2023), p. 11056-11068. -
További szerzők:	Kiffe-Delf, Anna-Lene Ostermann, Philipp Niklas Simons, Viktor Emanuel He, Di Gao, Ying van Geelen, Lasse Dai, Haofu Zhao, You-Xing Schaal, Heiner Mándi Attila (1981-) (vegyész, német szakfordító) Király Sándor Balázs (1991-) (vegyész) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Liu, Zhen Kalscheuer, Rainer
Pályázati támogatás:	K138672 OTKA FK134653 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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