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001-es BibID:	BIBFORM103531
035-os BibID:	(cikkazonosító)1176 (WoS)000856169800001 (Scopus)85138543871
Első szerző:	Mazzone, Flaminia
Cím:	In Vitro Biological Activity of Natural Products from the Endophytic Fungus Paraboeremia selaginellae against Toxoplasma gondii / Flaminia Mazzone, Viktor E. Simons, Lasse van Geelen, Marian Frank, Attila Mándi, Tibor Kurtán, Klaus Pfeffer, Rainer Kalscheuer
Dátum:	2022
ISSN:	2079-6382
Megjegyzések:	Toxoplasma gondii is an apicomplexan pathogen able to infect a wide range of warm-blooded animals, including humans, leading to toxoplasmosis. Current treatments for toxoplasmosis are associated with severe side-effects and a lack efficacy to eradicate chronic infection. Thus, there is an urgent need for developing novel, highly efficient agents against toxoplasmosis with low toxicity. For decades, natural products have been a useful source of novel bioactive compounds for the treatment of infectious pathogens. In the present study, we isolated eight natural products from the crude extract of the endophytic fungus Paraboeremia selaginellae obtained from the leaves of the plant Philodendron monstera. The natural products were tested for inhibiting Toxoplasma gondii proliferation, and their cytotoxicity was evaluated in different human cell lines. Six natural products showed antitoxoplasma activity with low or no cytotoxicity in human cell lines. Together, these findings indicate that biphenyl ethers, bioxanthracenes, and 5S,6S-phomalactone from P. selaginellae are potential candidates for novel anti-toxoplasma drugs.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Toxoplasma gondii Paraboeremia selaginellae endophytic fungi natural products bioactivity biphenyl ether bioxanthracene phomalactone
Megjelenés:	Antibiotics-Basel. - 11 : 9 (2022), p. 1-15. -
További szerzők:	Simons, Viktor Emanuel van Geelen, Lasse Frank, Marian Mándi Attila (1981-) (vegyész, német szakfordító) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Pfeffer, Klaus Kalscheuer, Rainer
Pályázati támogatás:	K138672 OTKA FK134653 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM120608
Első szerző:	Simons, Viktor Emanuel
Cím:	Colletodiol derivatives of the endophytic fungus Trichocladium sp. / Viktor E. Simons, Attila Mándi, Marian Frank, Lasse van Geelen, Nam Tran-Cong, Dorothea Albrecht, Annika Coort, Christina Gebhard, Tibor Kurtán, Rainer Kalscheuer
Dátum:	2024
ISSN:	0367-326X
Megjegyzések:	The OSMAC (one strain many compounds) concept is a cultivation-based approach to increase the diversity of secondary metabolites in microorganisms. In this study, we applied the OSMAC-approach to the endophytic fungus Trichocladium sp. by supplementation of the cultivation medium with 2.5% phenylalanine. This experiment yielded five new compounds, trichocladiol (1), trichocladic acid (2), colletodiolic acid (3), colletolactone (4) and colletolic acid (5), together with five previously described ones (6?10). The structures were elucidated via comprehensive spectroscopic measurements, and the absolute configurations of compound 1 was elucidated by using TDDFT-ECD calculations. For formation of compounds 3?5, a pathway based on colletodiol biosynthesis is proposed. Compound 6 exhibited strong antibacterial activity against methicillin-resistant Staphylococcus aureus with a minimal inhibitory concentration (MIC) of 0.78 ?M as well as a strong cytotoxic effect against the human monocytic cell line THP1 with an IC50 of 0.7 ?M. Compound 8 showed moderate antibacterial activity against Mycobacterium tuberculosis with a MIC of 25 ?M and a weak cytotoxic effect against THP1 cells with an IC50 of 42 ?M.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Trichocladium sp. OSMAC Dihydronaphthalenone Macrocarpon Colletodiol precursors Biosynthesis Antibacterial activity Cytotoxicity
Megjelenés:	Fitoterapia. - 175 (2024), p. 1-10. -
További szerzők:	Mándi Attila (1981-) (vegyész, német szakfordító) Frank, Marian van Geelen, Lasse Tran-Cong, Nam Michael Albrecht, Dorothea Coort, Annika Gebhard, Christina Kurtán Tibor (1973-) (vegyész, angol szakfordító) Kalscheuer, Rainer
Pályázati támogatás:	K138672 OTKA FK134653 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM114612
035-os BibID:	(WoS)001026992900001 (Scopus)85165695315
Első szerző:	Wang, Lin
Cím:	Asperphenalenones Isolated from the Biocontrol Agent Clonostachys rosea and Their Antimicrobial Activities / Lin Wang, Anna-Lene Kiffe-Delf, Philipp Niklas Ostermann, Viktor Emanuel Simons, Di He, Ying Gao, Lasse van Geelen, Hao-Fu Dai, You-Xing Zhao, Heiner Schaal, Attila Mándi, Sándor Balázs Király, Tibor Kurtán, Zhen Liu, and Rainer Kalscheuer
Dátum:	2023
ISSN:	0021-8561
Megjegyzések:	Clonostachys rosea is a fungus widely distributed on Earth and has a high capacity to adapt to complex environments in soil, plants, or sea. It is an endophyte that can be used as a potential biocontrol agent to protect plants from pathogenic fungi, nematodes, and insects. However, the spectrum of secondary metabolites produced by C. rosea has only scarcely been studied. In the present study, eight new phenalenones, asperphenalenones F-M (1-8), together with two known derivatives, asperphenalenones E and B (9 and 10), were isolated from the axenic rice culture of this fungus. The structures of the new compounds were elucidated by nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, electronic circular dichroism, and gas chromatography-mass spectrometry analyses. Asperphenalenones J-M (5-8) are unusual phenalenone adducts that are conjugated to diterpenoid glycosides. Asperphenalenones F and H showed moderate antibacterial activity against methicillin-resistant Staphylococcus aureus, with minimal inhibitory concentrations of 12.5 and 25 ?M, respectively. Asperphenalenone B exhibited low antiviral activity against the human immunodeficiency virus replication. Furthermore, asperphenalenones F and H exhibited low cytotoxicity against Jurkat cells, while all other compounds were devoid of cytotoxicity.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Clonostachys rosea asperphenalenones antibacterial activity methicillin-resistant Staphylococcus aureus (MRSA) anti-HIV activity
Megjelenés:	Journal of Agricultural and Food Chemistry. - 71 : 29 (2023), p. 11056-11068. -
További szerzők:	Kiffe-Delf, Anna-Lene Ostermann, Philipp Niklas Simons, Viktor Emanuel He, Di Gao, Ying van Geelen, Lasse Dai, Haofu Zhao, You-Xing Schaal, Heiner Mándi Attila (1981-) (vegyész, német szakfordító) Király Sándor Balázs (1991-) (vegyész) Kurtán Tibor (1973-) (vegyész, angol szakfordító) Liu, Zhen Kalscheuer, Rainer
Pályázati támogatás:	K138672 OTKA FK134653 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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