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001-es BibID:	BIBFORM109052
035-os BibID:	(cikkazonosító)401 (Scopus)85151113623 (WoS)000953989400001
Első szerző:	Diószegi Ágnes (belgyógyász)
Cím:	Role of Altered Metabolism of Triglyceride-Rich Lipoprotein Particles in the Development of Vascular Dysfunction in Systemic Lupus Erythematosus / Diószegi Ágnes, Lőrincz Hajnalka, Kaáli Eszter, Soltész Pál, Perge Bianka, Varga Éva, Harangi Mariann, Tarr Tünde
Dátum:	2023
ISSN:	2218-273X
Megjegyzések:	Background: Impaired lipid metabolism contributes to accelerated inflammatory responses in addition to promoting the formation of atherosclerosis in systemic lupus erythematosus (SLE). We aimed to evaluate the lipid profile, inflammatory markers, and vascular diagnostic tests in active SLE patients to clarify the association between dyslipidemia and early vascular damage. Patients and Methods: 51 clinically active SLE patients and 41 age- and gender-matched control subjects were enrolled in the study. Lipoprotein subfractions were detected by Lipoprint. Brachial artery flow-mediated dilation and common carotid intima-media thickness were detected by ultrasonography. Arterial stiffness indicated by augmentation index (Aix) and pulse wave velocity was measured by arteriography. Results: We found significantly higher Aix, higher VLDL ratio, plasma triglyceride, ApoB100, and small HDL, as well as lower HDL-C, large HDL, and ApoA1 in patients with SLE. There was a significant positive correlation of Aix with triglyceride, VLDL, IDL-C, IDL-B, and LDL1. A backward stepwise multiple regression analysis showed IDL-C subfraction to be the best predictor of Aix. Conclusions: Our results indicate that in young patients with SLE, triglyceride-rich lipoproteins influence vascular function detected by Aix. These parameters may be assessed and integrated into the management plan for screening cardiovascular risk in patients with SLE.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk systemic lupus erythematosus carotid intima-media thickness augmentation index flow-mediated dilation triglyceride very low-density lipoprotein intermediate-density lipoprotein triglyceride-rich lipoproteins
Megjelenés:	Biomolecules. - 13 : 3 (2023), p. 1-13. -
További szerzők:	Lőrincz Hajnalka (1986-) (biológus) Kaáli Eszter Soltész Pál (1961-) (belgyógyász, kardiológus) Perge Bianka Varga Éva (1982-) (belgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Tarr Tünde (1976-) (belgyógyász, allergológus és klinikai immunológus)
Pályázati támogatás:	Tématerületi Kiválósági Program Egyéb K142273 NKFIH TKP2021-EGA-18 Egyéb TKP2021-EGA Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM118904
035-os BibID:	(cikkazonosító)530
Első szerző:	Nagy Nikolett (belgyógyász)
Cím:	Antiphospholipid Antibodies Are Major Risk Factors for Non-Thrombotic Cardiac Complications in Systemic Lupus Erythematosus / Nagy Nikolett, Bói Bernadett, Papp Gábor, Fiák Edit, Gáspár-Kiss Eszter, Perge Bianka, Farmasi Nikolett, Tarr Tünde
Dátum:	2024
ISSN:	2227-9059
Megjegyzések:	In systemic lupus erythematosus (SLE), cardiovascular complications are among the leading causes of death. Cardiovascular risk in SLE is even higher in the presence of antiphospholipid antibodies or secondary antiphospholipid syndrome (APS). The aim of this retrospective, single-center study was to investigate the occurrence of antiphospholipid antibodies and non-thrombotic cardiac manifestations in 369 SLE patients. We also assessed the clinical and laboratory characteristics of the patients to reveal the risk factors for cardiac manifestations. Patients were divided into two groups based on the presence of antiphospholipid antibodies (APA); 258 (69.9%) patients were APA positive, and 111 (30.1%) patients were APA negative. Mitral and tricuspid insufficiency, aortic stenosis and pulmonary arterial hypertension were more common in APA-positive patients. Anticardiolipin IgG showed the strongest correlation with any non-thrombotic cardiac manifestations. Based on our results, the adjusted global antiphospholipid syndrome score (aGAPSS) above 8.5 is predictive of valvulopathies and ischemic heart disease, while aGAPSS above 9.5 is predictive of cardiomyopathies. The presence of antiphospholipid antibodies may affect the development of cardiac manifestations in SLE. Periodic cardiological and echocardiographic screening of patients without cardiac complaints, as well as regular monitoring of antiphospholipid antibodies, have great importance during the treatment of SLE patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk systemic lupus erythematosus antiphospholipid antibodies non-thrombotic cardiac manifestations aGAPSS
Megjelenés:	Biomedicines. - 12 : 3 (2024), p. 1-15. -
További szerzők:	Bói Bernadett Papp Gábor (1984-) (belgyógyász) Fiák Edit Gáspár-Kiss Eszter (1997-) (rezidens) Perge Bianka Farmasi Nikolett (1989-) (orvos) Tarr Tünde (1976-) (belgyógyász, allergológus és klinikai immunológus)
Pályázati támogatás:	OTKA-124177 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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