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001-es BibID:	BIBFORM072581
035-os BibID:	(cikkazonosító)1017 (scopus)85044643567 (wos)000434978700096
Első szerző:	Czompa Attila (gyógyszerész)
Cím:	Aged (Black) versus Raw Garlic against Ischemia/Reperfusion-Induced Cardiac Complications / Attila Czompa, Kitti Szoke, Jozsef Prokisch, Alexandra Gyongyosi, Istvan Bak, Gyorgy Balla, Arpad Tosaki, Istvan Lekli
Dátum:	2018
ISSN:	1661-6596 1422-0067
Megjegyzések:	Background: Recent evidence of studies suggests that aged black garlic also has health beneficial effect. The major aim of the present study is to compare the effect of raw and aged black garlic on postischemic cardiac recovery. Methods: Male Sprague Dawley rats were randomly divided into three groups. Animals of the first group were fed with raw garlic, animals of the second group received aged black garlic, while the third group served as vehicle treated control. At the end of the treatment, isolated hearts were undertaken to ischemia/reperfusion. Heart function and infarct size were measured and the level of HO-1 and iNOS were studied. Results: We have found superior postichemic cardiac function and reduced infarct size in both garlic treated groups compared to the drug-free control group, indicating cardioprotective effects. However, no significant differences between the garlic treated groups were observed. Our Western blot analysis revealed that raw garlic enhanced the level of HO-1 before ischemia, while in ischemic samples we found elevated HO-1 expression in both garlic treated groups. The level of iNOS was the same before ischemia in all groups, however, a markedly reduced iNOS level in ischemic/reperfused hearts originated from control and raw garlic treated animals was observed. In samples from aged black garlic treated animals, the level of iNOS was not significantly reduced after ischemia/reperfusion.Conclusion: Taken together our results indicate that not only raw but also aged black garlic also possesses cardioprotective effect.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban garlic ischemia hemeoxygenase reperfusion heart
Megjelenés:	International Journal of Molecular Sciences. - 19 : 4 (2018), p. 1-13. -
További szerzők:	Szőke Kitti (1989-) (gyógyszerész) Prokisch József (1966-) (vegyész) Gyöngyösi Alexandra (1990-) (táplálkozástudományi szakember) Bak István (1975-) (vegyész, analitikus, farmakológus) Balla György (1953-) (csecsemő és gyermekgyógyász, neonatológus) Tósaki Árpád (1958-) (kísérletes farmakológus, gyógyszerész) Lekli István (1981-) (gyógyszerész)
Pályázati támogatás:	OTKA-PD-111794 OTKA NKFI-124719 NKFI TÁMOP 4.2.4. A/2-11-1-2012-0001 TÁMOP GINOP-2.3.2-15-2016-00043 GINOP EFOP-3.6.1-16-2016-00022 EFOP ÚNKP-17-4-III-DE-219 ÚNKP
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM064493
035-os BibID:	(cikkazonosító)1047 (scopus)85016422224 (wos)000381500900062
Első szerző:	Szemán-Nagy Gábor (biológia tanár-molekuláris biológus)
Cím:	In situ electron microscopy of lactomicroselenium particles in probiotic bacteria / Nagy Gábor, Pinczes Gyula, Pintér Gábor, Pócsi István, Prokisch József, Bánfalvi Gáspár
Dátum:	2016
ISSN:	1661-6596 1422-0067
Megjegyzések:	Electron microscopy was used to test whether or not (a) in statu nascendi synthesized, and in situ measured, nanoparticle size does not differ significantly from the size of nanoparticles after their purification; and (b) the generation of selenium is detrimental to the bacterial strains that produce them. Elemental nano-sized selenium produced by probiotic latic acid bacteria was used as a lactomicroselenium (lactomicroSel) inhibitor of cell growth in the presence of lactomicroSel, and was followed by time-lapse microscopy. The size of lactomicroSel produced by probiotic bacteria was measured in situ and after isolation and purification. For these measurements the TESLA BS 540 transmission electron microscope was converted from analog (aTEM) to digital processing (dTEM), and further to remote-access internet electron microscopy (iTEM). Lactobacillus acidophilus produced fewer, but larger, lactomicroSel nanoparticles (200?350 nm) than Lactobacillus casei (L. casei), which generated many, smaller lactomicroSel particles (85?200 nm) and grains as a cloudy, less electrodense material. Streptococcus thermophilus cells generated selenoparticles (60-280 nm) in a suicidic manner. The size determined in situ in lactic acid bacteria was significantly lower than those measured by scanning electron microscopy after the isolation of lactomicroSel particles obtained from lactobacilli (100?500 nm), but higher relative to those isolated from Streptococcus thermopilus (50?100 nm). These differences indicate that smaller lactomicroSel particles could be more toxic to the producing bacteria themselves and discrepancies in size could have implications with respect to the applications of selenium nanoparticles as prebiotics.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban transmission electronmicroscopy lactomicroSel nanoparticles lactobacilli Streptococcus thermophilus S. thermophilus
Megjelenés:	International Journal of Molecular Sciences. - 17 : 7 (2016), p. 1-8. -
További szerzők:	Pinczes Gyula Pintér Gábor Pócsi István (1961-) (vegyész) Prokisch József (1966-) (vegyész) Bánfalvi Gáspár (1943-) (sejtbiológus, gyógyszerész)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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