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001-es BibID:	BIBFORM005090
Első szerző:	Nagy Péter (biofizikus)
Cím:	ICAM-1 inhibits the homocluster formation of MHC-I in colon carcinoma cells / Nagy, P., Vamosi, G., Damjanovich, S., Damjanovich, L.
Dátum:	2006
ISSN:	006-291X (Print)
Megjegyzések:	ICAM-1 and MHC-I proteins play fundamental roles in antigen presentation, activation of T lymphocytes, and immune responses against tumor cells. Both of them participate in the formation of lipid raft-associated membrane protein clusters. We found significant colocalization between ICAM-1 and MHC-I at the level of large-scale associations. We combined RNA interference and fluorescence resonance energy transfer studies to show that ICAM-1 promotes the partial disassembly of MHC-I homoclusters on LS-174T colon carcinoma cells. Interferon-gamma (IFN-gamma) treatment induced an increase in the expression of MHC-I and ICAM-1 resulting in decreased MHC-I homoassociation. Small interfering RNAs directed against ICAM-1 restored the homoassociation of MHC-I without influencing the expression level of MHC-I by eliminating ICAM-1 molecules interspersed in MHC-I clusters. We conclude that the composition of membrane protein clusters is dynamically altered in response to both physiological and experimentally elicited changes in antigen expression levels.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Antigen Presentation Antigens Biophysics Carcinoma Cell Line, Tumor Cells Colonic Neoplasms Energy Transfer Fluorescence Fluorescence Resonance Energy Transfer genetics Histocompatibility Antigens Histocompatibility Antigens Class I Humans Hungary Intercellular Adhesion Molecule-1 Lymphocytes metabolism Protein Binding Proteins Research RNA,Small Interfering Support T-Lymphocytes
Megjelenés:	Biochemical and Biophysical Research Communications. - 347 : 3 (2006), p. 758-763. -
További szerzők:	Vámosi György (1967-) (biofizikus) Damjanovich Sándor (1936-2017) (biofizikus) Damjanovich László (1960-) (általános sebész)
Internet cím:	DOI elektronikus változat
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001-es BibID:	BIBFORM005107
Első szerző:	Vámosi György (biofizikus)
Cím:	The role of supramolecular protein complexes and membrane potential in transmembrane signaling processes of lymphocytes / Vamosi, G., Bodnar, A., Damjanovich, S., Nagy, P., Varga, Z., Damjanovich, L.
Dátum:	2006
ISSN:	165-2478 (Print)
Megjegyzések:	The formation of protein patterns in lymphocyte plasma membranes is analyzed in the light of past and, also, very recent experiments. The analysis surveys the lateral organization of major histocompatibility complex glycoproteins, intercellular adhesion molecule-1, interleukin-2 and -15 receptors, Kv1.3 K+ ion channels and the T-cell receptor as well as their behavior under different conditions. These molecules form small- and large-scale clusters in the membrane of human lymphocytes. Many of the association motifs occur in other investigated cell types. The conclusions point toward a possible role for ion channel activities, membrane potential changes and alterations of the lateral organization of proteins in transmembrane signaling and cytotoxic interactions. In our outlook new factors that potentially affect membrane protein cluster formation and interactions are discussed. A role for MHC glycoproteins in concentrating membrane proteins and organizing protein patterns is suggested, and the possibility that the membrane potential may modulate protein conformation and, thereby, affect protein-protein interactions is pointed out. A well-defined role for the presence of ion channels in the immune synapse is offered, which could explain the significance of ion channel accumulation in the immune synapse together with the T-cell receptor.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban analysis Animals Biophysics Cell Membrane Glycoproteins Human Humans Hungary immunology Intercellular Adhesion Molecule-1 Interleukin-2 Ion Channels Light Lymphocytes Major Histocompatibility Complex Membrane Potentials Membrane Proteins metabolism Multiprotein Complexes physiology Protein Conformation Proteins Research Signal Transduction Support T-Lymphocytes
Megjelenés:	Immunology Letters. - 104 : 1-2 (2006), p. 53-58. -
További szerzők:	Dóczy-Bodnár Andrea (1970-) (biofizikus) Damjanovich Sándor (1936-2017) (biofizikus) Nagy Péter (1971-) (biofizikus) Varga Zoltán (1969-) (biofizikus, szakfordító) Damjanovich László (1960-) (általános sebész)
Internet cím:	DOI elektronikus változat
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