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1.

001-es BibID:BIBFORM056517
Első szerző:Albelda, Steven M.
Cím:The role of integrins in development : structure, function, and tissue specific expression / S. M. Albeda, J. Solowska, J. M. Edelman, L. Damjanovich, Clayton A. Buck
Dátum:1990
ISBN:978-2222045281
Tárgyszavak:Orvostudományok Elméleti orvostudományok könyvfejezet
Megjelenés:The Avian model in developmental biology : from organism to genes / [eds. du Centre National de la Recherche Scientifique]. - p. 261-280. -
További szerzők:Solowska, Joanna Edelman, Jonathan M. Damjanovich László (1960-) (általános sebész) Buck, Clayton A.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM024976
Első szerző:Albelda, Steven M.
Cím:Integrin distribution in malignant melanoma : association of the beta 3 subunit with tumor progression / Albelda S. M, Mette S. A., Elder D. E., Stewart R., Damjanovich L., Herlyn M., Buck C. A.
Dátum:1990
ISSN:0008-5472
Megjegyzések:Since tumor progression is dependent on the ability of malignant cells to interact with the extracellular matrix, molecules on the cell surface which mediate cell-substratum interactions are likely to be important regulators of tumor invasion and metastasis. The purpose of this study was to examine the distribution of one such group of cell adhesion receptors, the integrins, in benign and malignant lesions of human melanocytes. The distribution of integrin adhesion receptors was defined on cells in culture derived from normal and malignant melanocytes and in tissue sections from benign to increasingly malignant melanocytic lesions using a panel of monoclonal antibodies against specific integrin subunits. Cells in culture expressed a large variety of integrins, including all of the previously characterized members of the beta 1 subfamily plus the alpha v/beta 3 vitronectin receptor. The expression of integrins was similar in cells cultured from either benign or malignant lesions. In contrast, consistent differences were noted in integrin expression by cells within tissues containing metastatic and vertical growth phase melanomas when compared to radial growth phase melanoma cells and cells within nevi. Most notably, the expression of the beta 3 subunit was restricted exclusively to cells within vertical growth phase and metastatic melanomas. The presence of this integrin may be important in the development of tumor invasiveness and could be useful as a marker of melanoma cells entering the more aggressive phase of the malignant process.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Cancer Research. - 50 : 20 (1990), p. 6757-6764. -
További szerzők:Mette, Stephen A. Elder, David E. Stewart, RoseMary Damjanovich László (1960-) (általános sebész) Herlyn, Meenhard Buck, Clayton A.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM034270
Első szerző:Buck, Clayton A.
Cím:Immunohistochemical and molecular analysis of beta 1 and beta 3 integrins / Buck C., Albelda S., Damjanovich L., Edelman J., Shih D. T., Solowska J.
Dátum:1990
Megjegyzések:The expression and function of integrin subunits was examined by immunohistochemical staining of normal and malignant tissues and by producing specific changes in avian beta subunit cDNA that were subsequently expressed in mammalian cells. Most tissues express only a restricted number of integrins. These include primarily those thought to function as collagen/laminin receptors. With the exception of metastatic melanomas, tumors show a general down regulation of integrins. Structure/function studies of the beta subunit show that the cytoplasmic domain is required for inclusion in adhesion plaques and for promotion of adhesive functions; that the transmembrane domain is required for subunit association, but not proper alpha subunit selection; and that the amino terminal one third of the subunit must remain intact for subunit selection and ligand binding to occur.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Cell Differentiation and Development. - 32 : 3 (1990), p. 189-202. -
További szerzők:Albelda, Steven M. Damjanovich László (1960-) (általános sebész) Edelman, Jon Shih, Daw-Tsun Solowska, Joanna
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM024982
Első szerző:Damjanovich László (általános sebész)
Cím:Distribution of integrin cell adhesion receptors in normal and malignant lung tissue / Damjanovich L., Albelda S. M., Mette S. A., Buck C. A.
Dátum:1992
Megjegyzések:The integrins are a family of transmembrane glycoproteins that serve as cell-cell and cell-substratum adhesion molecules and help regulate cellular morphology, differentiation, and proliferation. The integrin repertoire of a cell may therefore influence its behavior under resting conditions or following malignant transformation. For this reason, the distribution of integrins in normal lung tissues was determined using monoclonal antibodies against integrins of the beta 1 (VLA) and beta 3 (cytoadhesin) subfamilies and compared with the distribution in a limited number of lung carcinomas. The integrin subunits that bind to collagen and laminin (alpha 1, alpha 2, alpha 3, and alpha 6) and the alpha subunit, which can pair with beta 1, beta 3, or beta 5 and promote fibronectin, fibrinogen, or vitronectin binding, were the predominant integrins expressed on the major cell types of the lung, i.e., bronchial epithelium, vascular endothelium, and smooth muscle. Strong expression of the alpha 5 beta 1 fibronectin receptor and the beta 3 subunit was restricted to the endothelium of large vessels. Integrin expression by the lung carcinoma cells was somewhat heterogeneous; however, the tumors tended to express fewer integrins than did the normal bronchial epithelium.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:American Journal of Respiratory Cell and Molecular Biology. - 6 : 2 (1992), p. 197-206. -
További szerzők:Albelda, Steven M. Mette, Stephen A. Buck, Clayton A.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM034259
Első szerző:Lessey, Bruce A.
Cím:Integrin adhesion molecules in the human endometrium : correlation with the normal and abnormal menstrual cycle / Lessey B. A., Damjanovich L., Coutifaris C., Castelbaum A., Albelda S. M., Buck C. A.
Dátum:1992
Megjegyzések:Integrins are a class of cell adhesion molecules that participate in cell-cell and cell-substratum interactions and are present on essentially all human cells. The distribution of nine different alpha and beta integrin subunits in human endometrial tissue at different stages of the menstrual cycle was determined using immunoperoxidase staining. Glandular epithelial cells expressed primarily alpha 2, alpha 3, and alpha 6 (collagen/laminin receptors), while stromal cells expressed predominantly alpha 5 (fibronectin receptor). The presence of alpha 1 on glandular epithelial cells was cycle specific, found only during the secretory phase. Expression of both subunits of the vitronectin receptor, alpha v beta 3, also underwent cycle specific changes on endometrial epithelial cells. Immunostaining for alpha v increased throughout the menstrual cycle, while the beta 3 subunit appeared abruptly on cycle day 20 on luminal as well as glandular epithelial cells. Discordant luteal phase biopsies (greater than or equal to 3 d "out of phase") from infertility patients exhibited delayed epithelial beta 3 immunostaining. These results demonstrate similarities, as well as specific differences, between endometrium and other epithelial tissues. Certain integrin moieties appear to be regulated within the cycling endometrium and disruption of integrin expression may be associated with decreased uterine receptivity and infertility.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The Journal of Clinical Investigation. - 90 : 1 (1992), p. 188-195. -
További szerzők:Damjanovich László (1960-) (általános sebész) Coutifaris, Christos Castelbaum, Arthur Albelda, Steven M. Buck, Clayton A.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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