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001-es BibID:	BIBFORM047052
035-os BibID:	PMID:2854691
Első szerző:	Farkas Ilona (biokémikus)
Cím:	Activation/dephosphorylation of rabbit muscle glycogen synthase by the catalytic subunits of protein phosphatase-1 and 2A / Ilona Farkas, B. Tóth, Gy. Vereb, Csilla Csortos, P. Gergely
Dátum:	1988
ISSN:	0237-6261
Megjegyzések:	Glycogen synthase a was purified from rabbit skeletal muscle by a procedure involving heparin-Sepharose chromatography. Glycogen synthase a was phosphorylated by the catalytic subunit of cAMP-dependent protein kinase to give synthase b1. Dephosphorylation and activation of synthase b1 was investigated using the catalytic subunits of protein phosphatase-1 and 2A. The dephosphorylation and activation of synthase b1 was biphasic with a larger rate constant for the initial phase. Analysis of tryptic phosphopeptides of glycogen synthase during the course of dephosphorylation revealed a faster initial phosphate release from site-2 by both phosphatases comparing to sites-1a and 1b. Ligand effects on synthase phosphatase reactions were also studied. Spermine was found to inhibit protein phosphatase-1 activity and to stimulate type-2A phosphatase using synthase b1 as substrate.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Acta Biochimica et Biophysica Hungarica. - 23 : 3-4 (1988), p. 231-246. -
További szerzők:	Tóth Béla (1954-) (vegyész, biokémikus) Vereb György (1938-) (biokémikus, sejtbiológus) Csortos Csilla (1956-) (biokémikus) Gergely Pál (1947-) (biokémikus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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