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001-es BibID:	BIBFORM069464
Első szerző:	Kappelmayer János (laboratóriumi szakorvos)
Cím:	Clinical laboratories : production factories or specialized diagnostic centers / János Kappelmayer, Judit Tóth
Dátum:	2016
Megjegyzések:	Since a large proportion of medical decisions arebased on laboratory results, clinical laboratoriesshould meet the increasing demand of clinicians andtheir patients. Huge central laboratories may processover 10 million tests annually; they act as productionfactories, measuring emergency and routinetests with sufficient speed and accuracy. At the sametime, they also serve as specialized diagnostic centerswhere well-trained experts analyze and interpretspecial test results. It is essential to improve andconstantly monitor this complex laboratory service,by several methods. Sample transport by pneumatictube system, use of an advanced laboratory informationsystem and point-of-care testing may result indecreased total turnaround time. The optimizationof test ordering may result in a faster and more costeffectivelaboratory service. Autovalidation can savetime for laboratory specialists, when the analysis ofmore complex results requires their attention. Smallteams of experts responsible for special diagnosticwork, and their interpretative reporting according topredetermined principles, may help to minimize subjectivityof these special reports. Although laboratoryinvestigations have become so diversely developed in the past decades, it is essential that the laboratorycan provide accurate results relativelyquickly, and that laboratory specialists can supportthe diagnosis and monitoring of patientsby adequate interpretation of esoteric laboratorymethods.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban turnaround time autovalidation interpretative results
Megjelenés:	The Electronic Journal of the International Federation of Clinical Chemistry and laboratory Medicine. - 27 : 2 (2016), p. 156-165. -
További szerzők:	Tóth Judit (1978-) (laboratóriumi szakorvos)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM075565
Első szerző:	Nagy Gábor (laboratóriumi szakorvos, laboratóriumi hematológus és immunológus)
Cím:	Diagnostic algorithm for antinuclear antibody testing : clinical and financial considerations / G. Nagy, I. Csípő, E. Gyimesi, J. Tóth, S. Demeter, P. Antal-Szalmás
Dátum:	2018
Megjegyzések:	The diagnostics of autoimmune rheumatic diseases strongly depends on laboratory tests, dominantly on autoantibody determinations. Several techniques and assay types are available for evaluation of the autoantibody profile of these patients. The most widely used indirect immunofluorescence (IIF) assay on HEp-2 cells can identify dozens of antinuclear (ANA) and anti-cytoplasmic autoantibodies, while ELISA-s or immunoblots utilizing mixed or single antigens can identify the exact specificity of them. Since the application (replacement and sequential order) of these tests is rather ambiguous we developed an algorithm for the most frequently used antinuclear and anti-cytoplasmic autoantibodies and evaluated clinical and financial efficacy of this novel system. The number and results of autoantibody determinations (ANA HEp-2 IIF, anti-dsDNA and anti-ENA tests) between January and June, 2017 were collected from our laboratory information system (GLIMS). The theoretical number of autoantibody tests was recalculated along the following rule: anti-dsDNA and anti-ENA tests were performed only if ANA HEp-2 IIF was positive. Separate analyses were performed taking into account the ANA HEp-2 IIF patterns and titers, too. Our results showed that the ANA HEp-2 IIF guided selection of anti-dsDNA and anti-ENA ELISAs could reduce the number of anti-dsDNA and anti-ENA tests by 48% and 56%, sparing about 7.1M HUF per year. The rate of ANA HEp-2 IIF negative but anti-dsDNA positive cases was 1.8%, meaning 64 samples, from which 16 patients (0.45%) had significantly higher (>2x URL) anti-dsDNA value. The rate of ANA HEp-2 IIF negative but anti-ENA positive samples was 1.1% (56 cases). 14 and 19 of these patients showed only anti-SS-A or anti-Jo-1 positivity, known to be weakly reactive on HEp-2 cells. The described sequential application of ANA HEp-2 IIF assay, anti-dsDNA and anti-ENA ELISAs provided high clinical efficacy and proved to be cost-effective.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:	Clinical Chemistry and Laboratory Medicine. - 56 : 9 (2018), p. eA139-eA140. -
További szerzők:	Csípő István (1953-) (vegyész) Gyimesi Edit (1957-) (klinikai biokémikus, vegyész) Tóth Judit (1978-) (laboratóriumi szakorvos) Demeter S. Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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