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001-es BibID:	BIBFORM108355
035-os BibID:	(cikkazonosító)556 (WoS)000933828200001 (Scopus)85147861701
Első szerző:	Rákóczi Éva (klinikai szakorvos)
Cím:	Evaluation of the Efficacy of BBIBP-CorV Inactivated Vaccine Combined with BNT62b2 mRNA Booster Vaccine / Éva Rákóczi, Gusztáv Magócs, Sára Kovács, Béla Nagy, Gabriella Szűcs, Zoltán Szekanecz
Dátum:	2023
ISSN:	2075-4418
Megjegyzések:	Abstract: Objectives: In this prospective study, SARS-CoV??2 spike protein specific total immunoglobulin (Ig) levels were analyzed before and after BNT162 b2 mRNA booster vaccination in individuals previously administered with two doses of BBIBP-CorV vaccine in comparison to immunized participants with three doses of BNT162 b2 vaccination. Methods: Sixty-one Caucasian volunteers (39 females, 22 males) vaccinated by BBIBP-CorV were included (mean age: 63.9 years). Sixty-one patients (41 females, 20 males) as controls were vaccinated with BNT162b2 (mean age: 59.9 years). Both groups received the third booster BNT162b2 vaccine. Total anti-SARS-CoV??2 S1-RBD Ig levels were measured by an immunoassay (Roche Diagnostics) and their calculated ratios after/before booster dose were compared between the two groups. Results: At baseline, significantly lower anti-SARS-CoV??2 S1-RBD total antibody levels were determined after initial immunization by two doses of inactivated BBIBP-CorV compared to BNT62b2 mRNA vaccine (p < 0.001). After BNT162b2 boosters, similarly high total Ig levels were detected in both the heterologous (27,195 [15,604?42,754] BAU/mL, p < 0.001) and the homologous booster cohort (24,492 [13,779??42,671] BAU/mL, p < 0.001) compared to baseline. Hence, the ratio of after/before total Ig levels was significantly higher with heterologous vs homologous immunization (p < 0.001). Conclusion: To address the concept that basic BBIBP-CorV vaccination is not as effective as BNT162b, we analyzed the effect of heterologous vaccination with BNT162b2. Our results suggest that BNT162b2 can successfully boost the effects of two-dose BBIBP-CorV vaccination.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk COVID-19 BBIBP-CorV BNT62b2 booster vaccine
Megjelenés:	Diagnostics. - 13 : 3 (2023), p. 1-12. -
További szerzők:	Magócs Gusztáv Kovács Sára Nagy Béla Jr. (1980-) (labordiagnosztikai szakorvos) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
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