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001-es BibID:	BIBFORM061583
Első szerző:	Csongrádi Éva (szakorvos)
Cím:	Role of carbon monoxide in kidney function : is a little carbon monoxide good for the kidney? / Csongradi, E., Juncos, L. A., Drummond, H. A., Vera, T., Stec, D. E.
Dátum:	2012
Megjegyzések:	Carbon monoxide (CO) is an endogenously produced gas resulting from the degradation of hemeby heme oxygense or from fatty acid oxidation. Heme oxygenase (HO) enzymes are constitutivelyexpressed in the kidney (HO-2) and HO-1 is induced in the kidney in response to severalphysiological and pathological stimuli. While the beneficial actions of HO in the kidney have beenrecognized for some time, the important role of CO in mediating these effects has not been fullyexamined. Recent studies using CO inhalation therapy and carbon monoxide releasing molecules(CORMs) are demonstrating that increases in CO alone can be beneficial to the kidney in severalforms of acute renal injury by limiting oxidative injury, decreasing cell apoptosis, and promotingcell survival pathways. Renal CO is also emerging as a major regulator of renal vascular andtubular function acting to protect the renal vasculature against excessive vasoconstriction and topromote natriuresis by limiting sodium reabsorption in tubule cells. Within this review, recentstudies on the physiological actions of CO in the kidney will be explored as well as the potentialtherapeutic avenues that are being developed targeting CO in the kidney which may be beneficialin diseases such as acute renal failure and hypertension.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban Heme oxygenase renal failure blood pressure bilirubin acute renal injury
Megjelenés:	Current pharmaceutical biotechnology 13 : 6 (2012), p.819-826. -
További szerzők:	Juncos, Luis A. Drummond, Heather A. Vera, Trinity Stec, David E.
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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