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001-es BibID:BIBFORM113512
035-os BibID:(scopus)85150972590 (wos)000956853000001
Első szerző:Fayed, Ahmed
Cím:Is the combination of linagliptin and allopurinol better prophylaxis against post-contrast acute kidney injury? A multicenter prospective randomized controlled study / Ahmed Fayed, Ahmed A. Hammad, Dina O. Abdulazim, Hany Hammad, Mohamed Amin, Samir Elhadidy, Mona M. Salem, Ibrahim M. Abd ElAzim, Lajos Zsom, Éva Csongradi, Karim M. Soliman, Usama A. Sharaf El Din
Dátum:2023
ISSN:0886-022X
Megjegyzések:Background Patients with diabetic kidney disease (DKD) are at increased risk to develop post-contrast acute kidney injury (AKI). Diabetic patients under dipeptidyl peptidase 4 inhibitors (DPP4Is) experience a lower propensity to develop AKI. We speculated that linagliptin as a single agent or in combination with allopurinol may reduce the incidence of post-contrast AKI in stage 3-5 chronic kidney disease (CKD) patients with underlying DKD. Methods Out of 951 DKD patients eligible for this study, 800 accepted to sign informed consent. They were randomly allocated to 4 equal groups that received their prophylaxis for 2 days before and after radiocontrast. The first control group received N-acetyl cysteine and saline, the 2(nd) received allopurinol, the 3(rd) group received linagliptin, and the 4(th) received both allopurinol and linagliptin. Post-procedure follow-up for kidney functions was conducted for 2 weeks in all patients. Results 20, 19, 14, and 8 patients developed post-contrast AKI in groups 1 through 4, respectively. Neither linagliptin nor allopurinol was superior to N-acetyl cysteine and saline alone. However, the combination of the two agents provided statistically significant renal protection: post-contrast AKI in group 4 was significantly lower than in groups 1 and 2 (p < 0.02 and <0.03, respectively). None of the post-contrast AKI cases required dialysis. Conclusion Linagliptin and allopurinol in combination may offer protection against post-contrast AKI in DKD exposed to radiocontrast. Further studies are needed to support this view.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Renal Failure. - 45 : 1 (2023), p. p. 1-7. -
További szerzők:Hammad, Ahmed A. Abdulazim, Dina O. Hammad, Hany Amin, Mohamed Elhadidy, Samir Salem, Mona M. ElAzim, Ibrahim M. Abd Zsom Lajos (1968-) (belgyógyász, nefrológus) Csongrádi Éva (1969-) (szakorvos) Soliman, Karim M. Sharaf El Din, Usama A.
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2.

001-es BibID:BIBFORM061591
Első szerző:Fülöp Tibor (kardiológus)
Cím:Recalcitrant hypoglycemia resolved with 2.5% dextrose containing replacement fluid during hemodiafiltration / Fülöp Tibor, Iboaya, Benahili U., Avusula, Ramachandram, Csongrádi Éva, Juncos, Luis A.
Dátum:2013
ISSN:0886-022X
Megjegyzések:A 52-year-old African American male was admitted with acute kidney injury (AKI) four days afterrenal cryotherapy. He was started on continuous veno-venous hemodiafiltration (CVVHDF)immediately but his subsequent course was complicated by recurrent hypoglycemia, poorlyresponding to conventional therapy. To address the recalcitrant hypoglycemia, we changed thereplacement fluid to 5% dextrose in water with 150 mEq/L of sodium bicarbonate, Y-connectedwith 0.9% sodium chloride at a global rate of 2000 mL/hr, with resolution of refractoryhypoglycemia. A modified CVVHDF employing hyperglycemic solution can be a valuableaddition in treatment of AKI complicated by severe refractory hypoglycemia
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Acute kidney injury
continuous renal replacement therapy
hemodiafiltration
hypoglycemia
glipizide
sulfonylurea
Megjelenés:Renal Failure. - 35 : 7 (2013), p. 1035-7. -
További szerzők:Iboaya, Benahili U. (orvos) Avusula, Ramachandram (orvos) Csongrádi Éva (1969-) (szakorvos) Juncos Luis A. (orvos)
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3.

001-es BibID:BIBFORM061608
Első szerző:Fülöp Tibor (kardiológus)
Cím:The safety and efficacy of bedside removal of tunneled hemodialysis catheters by nephrology trainees / Fülöp Tibor, Tapolyai Mihály, Qureshi, Naseem A., Beemidi, Vikram R., Gharaibeh, Kamel A., Hamrahian, S. Mehrdad, Szarvas, Tibor, Kovesdy, Csaba P., Csongrádi, Éva
Dátum:2013
ISSN:0886-022X
Megjegyzések:BACKGROUND:Some nephrologists remove tunneled hemodialysis catheters (TDC) at the bedside, but this practice has never been formally studied. Our hypothesis was that bedside removal of TDC is a safe and effective procedure affording prompt removal, including in cases of suspected infection.METHODS:We reviewed our consecutive 3-year experience (2007-2009) with bedside TDC removal at the University of Mississippi Renal Fellowship Program. Data were collected on multiple patients and procedure-related variables, success and complication rates. Association between clinical characteristics and biomarkers of inflammation and myocardial damage was examined using correlation coefficients.RESULTS:Of 55 inpatient TDC removals (90.9% from internal jugular location), 50 (90.9%) were completed without hands-on assistance from faculty. Indications at the time of removal included bacteremia, fever or clinical sepsis with hemodynamic instability or respiratory failure. All procedures were successful, with no cuff retention noted; one patient experienced prolonged bleeding which was controlled with local pressure. Peak C-reactive protein (available in 63.6% of cohort) was 12.9???8.4?mg/dL (reference range: <0.49) and median troponin-I (34% available) was 0.534?ng/mL (IQR 0.03-0.9) (reference range: <0.034) and they did not correlate with each other. Abnormal troponin-I was associated with proven bacteremia (p?<?0.05) but not with systolic and diastolic BP or clinical sepsis.CONCLUSION:Our results suggest that bedside removal of TDC remains a safe and effective procedure regardless of site or indications. Accordingly, TDC removal should be an integral part of competent Nephrology training.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Renal Failure. - 35 : 9 (2013), p. 1264-1268, -
További szerzők:Tapolyai Mihály (1968-) (nefrológus) Qureshi, Naseem A. Beemidi, Vikram R. (orvos) Gharaibeh, Kamel A. (orvos) Hamrahian, S. Mehrdad (orvos) Szarvas Tibor (matematikus informatikus) Kovesdy Csaba P. (orvos) Csongrádi Éva (1969-) (szakorvos)
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