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001-es BibID:BIBFORM061583
Első szerző:Csongrádi Éva (szakorvos)
Cím:Role of carbon monoxide in kidney function : is a little carbon monoxide good for the kidney? / Csongradi, E., Juncos, L. A., Drummond, H. A., Vera, T., Stec, D. E.
Dátum:2012
Megjegyzések:Carbon monoxide (CO) is an endogenously produced gas resulting from the degradation of hemeby heme oxygense or from fatty acid oxidation. Heme oxygenase (HO) enzymes are constitutivelyexpressed in the kidney (HO-2) and HO-1 is induced in the kidney in response to severalphysiological and pathological stimuli. While the beneficial actions of HO in the kidney have beenrecognized for some time, the important role of CO in mediating these effects has not been fullyexamined. Recent studies using CO inhalation therapy and carbon monoxide releasing molecules(CORMs) are demonstrating that increases in CO alone can be beneficial to the kidney in severalforms of acute renal injury by limiting oxidative injury, decreasing cell apoptosis, and promotingcell survival pathways. Renal CO is also emerging as a major regulator of renal vascular andtubular function acting to protect the renal vasculature against excessive vasoconstriction and topromote natriuresis by limiting sodium reabsorption in tubule cells. Within this review, recentstudies on the physiological actions of CO in the kidney will be explored as well as the potentialtherapeutic avenues that are being developed targeting CO in the kidney which may be beneficialin diseases such as acute renal failure and hypertension.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Heme oxygenase
renal failure
blood pressure
bilirubin
acute renal injury
Megjelenés:Current pharmaceutical biotechnology 13 : 6 (2012), p.819-826. -
További szerzők:Juncos, Luis A. Drummond, Heather A. Vera, Trinity Stec, David E.
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001-es BibID:BIBFORM061612
Első szerző:Stec, David E.
Cím:Thick Ascending Loop of Henle (talh) Specific Expression of Ho-1 Attenuates the Development of Ang II-Dependent Hypertension / David E. Stec, Eva Csongradi, Trinity Vera, Heather A. Drummond, Nader G. Abraham
Dátum:2010
ISSN:0194-911X
Megjegyzések:Recent studies have demonstrated an important antihypertensive action of renal heme oxygenase-1 (HO-1) induction; however, the specific contribution of thick ascending loop of Henle (TALH) derived HO-1 to this response is unknown. We generated a transgenic mouse model in which expression of the human HO-1 cDNA was controlled by the uromodulin (Tamm-Horsfall protein, THP) promoter (TALH-HHO1). Expression of the HO-1 transgene was only detected in isolated microdissected TALH tubule segments by rt-PCR. TALH-HHO1 mice exhibited a significant increase in medullary HO-1 protein which co-localized with endogenous THP protein as determined by confocal microscopy. HO activity was significantly increased in the medulla of TALH-HHO1 mice as compared to controls (25?7 vs. 151 30 pmoles/bilirubin/ mg/hr, n=6, p0.05), however, no difference in cortical HO activity was observed between TALH-HHO1 and non-transgenic mice. The effect of enhanced TALH HO-1 on the blood pressure response to increased Angiotensin II (Ang II) was determined in mice in which Ang II (1 g/min/kg. s.c.) was infused via an osmotic minipump for 10 days. Conscious blood pressures were measured over the last five days using implanted catheters. Ang II hypertension was significantly attenuated in TALH-HHO1 mice as compared to non-transgenic mice and averaged 139?3 vs. 153?2 mmHg (n=5, p0.05) in each group respectively. The decrease in blood pressure in TALH-HHO1 transgenic mice was associated with a 60% decrease in the level of the NKCC2 transporter in the medulla as determined by Western blot. TALH-HHO1 mice also exhibited a 36% decrease in sodium reabsorption measure in isolated TAHL tubule segments by ouabain sensitive rubidium (Rb) uptake. Our results demonstrate that increased levels of HO-1 in the TALH can lower blood pressure via a mechanism that may include alterations in NKCC2 dependent sodium reabsorption.
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
Megjelenés:Hypertension 56 : 5 (2010), p. e60. -
További szerzők:Csongrádi Éva (1969-) (szakorvos) Vera, Trinity Drummond, Heather A. Abraham, Nader G. (tudományos segédmunkatárs)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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