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001-es BibID:	BIBFORM061586
Első szerző:	Csongrádi Éva (szakorvos)
Cím:	In Vivo Inhibition of Renal Heme Oxygenase with an Imidazole- Dioxolane Inhibitor / Csongradi, E., Vera, T., Rimoldi, J. M., Gadepalli, R. S.V., Stec, D. E.
Dátum:	2010
Megjegyzések:	Recent studies have indentified imidazole-dioxolane based compounds as novel heme oxyenase(HO) inhibitors. While these compounds have been demonstrated to be specific HO inhibitors invitro, they have yet to be used to inhibit renal HO activity in vivo. The goal of this study was todetermine the effectiveness of the imidazole-dioxolane HO-1 inhibitor, QC-13, in the inhibition ofrenal HO activity in vivo. HO-1 was induced in mice by treatment with cobalt protoporphyrin(CoPP). After 5 days, QC-13 was delivered either by continuous intrarenal medullay interstitialinfusion (IRMI) into one kidney at several concentrations for 72 hours or by two intraperitonealinjections over a 48 hour period. IRMI infusion of QC-13 at a concentration of 25 ?M resulted in asignificant decrease in medullary but not cortical HO activity as compared to CoPP treatedkidneys. IRMI infusion of QC-13 at a lower concentration (2.5 ?M) had no effect on eithermedullary or cortical HO activity in CoPP treated mice. In contrast, administration of QC-13 at ahigher concentration (250 ?M) resulted in a significant decrease in both medullary and corticalHO activity in CoPP treated mice. Systemic administration of QC-13 resulted in significantdecrease both renal cortical and medullary HO activity in CoPP treated mice. In contrast toclassical porphyrin based HO inhibitors, IRMI infusion of QC-13 did not induce HO-1 proteinlevels as determined by Western blot analysis of medullary protein samples. Our resultsdemonstrated that imidazole-dioxolane inhibitors are renal HO inhibitors in vivo and can inhibitHO activity independent of HO-1 induction. These inhibitors may be useful tools to elucidate therole of renal HO-1 in numerous physiologic and pathophysiologic conditions.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban Kidney Carbon Monoxide Cobalt Protoporyphrin Heme Oxygenase-1 Mouse
Megjelenés:	Pharmacological research 61 : 6 (2010), p. 525-530. -
További szerzők:	Vera, Trinity Rimoldi, John M. Gadepalli, Rama S.V. Stec, David E.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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