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001-es BibID:	BIBFORM061605
Első szerző:	Agarwal, Mohit
Cím:	Severe Symptomatic Hypocalcemia after Denosumab Administration in an End-Stage Renal Disease Patient on Peritoneal Dialysis with Controlled Secondary Hyperparathyroidism / Mohit Agarwal, Éva Csongrádi, Christian A. Koch, Luis A. Juncos, Vonda Echols, Mihály Tapolyai, Tibor Fülöp
Dátum:	2013
Megjegyzések:	We report the 1st case of severe, symptomatic hypocalcemia after denosumab (RANKLinhibitor) treatment in a peritoneal dialysis patient with secondary hyperparathyroidismand osteoporosis. A 58-year-old Caucasian female has been receiving chronicambulatory peritoneal dialysis for four years secondary to polycystic kidney disease.Laboratory studies revealed: albumin-corrected calcium 9.0 mg/dL, phosphorus 5 mg/dL,alkaline phosphatase (ALP) 58 U/L [normal, 40-105], albumin 3.4 gm/dL [normal, 3.6-5.4]and intact parathyroid hormone (PTH) 315 pg/mL [normal, 40-72]. Marked osteoporosiswas noted on the DXA scan, preventing her from renal transplantation considerations.She had failed conventional medical treatment, including per os calcium, monthlyergocalciferol (50,000 units/month), activated vitamin-D analog (doxercalciferol) andrenal-failure adjusted alendronate (70 mg twice a month). She was started onsubcutaneous denosumab 60 mg every 6 months. After her first dose, she developed aprogressive drop of calcium, phosphorus, bicarbonate and magnesium, in spite ofmassive escalation of doxercalciferol and calcium supplementation. Hypocalcemianadired at 6.3 mg/dL with symptomatic tetany, requiring a brief hospitalizationapproximately 7 weeks after denosumab treatment. Her elevated PTH rose furthertransiently (647 pg/mL), along with ALP (123 U/L). Bone-mineral parameters normalizedapproximately 3 months after denosumab administration. The observed phenomenonresembled the phenotype of "hungry bone syndrome" observed after surgicalparathyroidectomy.Conclusion: Treatment decisions based on bone densitometry results alone are nottransposable between patients with or without end-stage renal disease. Denosumab maylead to critical hypocalcemia in dialysis patients and further aggravate existing secondaryhyperparathyroidism.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	British Journal of Medicine & Medical Research. - 3 : 4 (2013), p. 1398-1406. -
További szerzők:	Csongrádi Éva (1969-) (szakorvos) Koch, Christian A. Juncos, Luis A. Echols, Vonda Tapolyai Mihály (1968-) (nefrológus) Fülöp Tibor (1957-) (kardiológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM068277
Első szerző:	Csongrádi Éva (szakorvos)
Cím:	Adipokines as atherothrombotic risk factors in obese subjects : associations with haemostatic markers and common carotid wall thickness / É. Csongrádi, M. Káplár, B. Nagy Jr., C. A. Koch, A. Juhász, L. Bajnok, Zs. Varga, I. Seres, Zs. Karányi, M. T. Magyar, L. Oláh, A. Facskó, J. Kappelmayer, Gy. Paragh
Dátum:	2017
ISSN:	0939-4753
Megjegyzések:	Background and aims: Some crucial associations between obesity-related altered adipokinelevels and the main factors of atherosclerotic, atherothrombotic processes are not fully known.We analysed the relationships of classic adipokines, namely leptin, resistin, adiponectin, tumour necrosisfactor-alpha (TNF-a), interleukin 6 (IL-6) with the markers of platelet activation, including meanplatelet volume (MPV), platelet surface/soluble P-selectin, platelet-derived microparticles (PMPs), theparameters of coagulation abnormalities and common carotid intima-media thickness (IMT) in obesepatients with or without atheroscleroticcomorbidities in comparison to age- and sex-matched controls.Methods and results: We enrolled 154 obese individuals, including 98 suffering from atheroscleroticconcomitant conditions, 56 free of atherosclerotic comorbidities and 62 healthy controls. Plasma levelsof leptin, resistin, adiponectin, TNF-a, IL-6, soluble P-selectin, and plasminogen activator inhibitor-1 antigen(PAI-1 ag) were analysed by ELISA. Platelet surface P-selectin and PMPs were measured by flowcytometry. IMT was detected by ultrasonography. Adipokines were closely associated withmarkers ofplatelet hyperactivity, hypercoagulability, hypofibrinolysis and IMT. Significant independent associationswere found between leptin and platelet count (p < 0.0001), MPV (p Z 0.019), PMPs(p < 0.0001), fibrinogen (pZ0.001), factor VIII (FVIII) activity (pZ0.035); adiponectin and PAI-1 ag(pZ0.035); resistin and soluble P-selectin (pZ0.002); TNF-a and PAI-1 ag (p < 0.0001); and IL-6and fibrinogen (pZ 0.011). Finally, leptin (p Z 0.0005), adiponectin (pZ 0.019), IL-6 (p Z 0.001),MPV(pZ0.0003), PMP (pZ0.008), and FVIII activity (pZ0.043)were independent predictors of IMT.Conclusion: Overall,we suggest that inobese subjects altered adipokinelevels playa key role incommoncarotid atherosclerosis both directly and through haemostatic parameters.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban Obesity Adipokines Atherosclerosis Haemostasis Common carotid intima-media thickness
Megjelenés:	Nutrition Metabolism And Cardiovascular Diseases 27 : 6 (2017), p. 571-580. -
További szerzők:	Káplár Miklós (1965-) (belgyógyász, diabetológus) Nagy Béla Jr. (1980-) (labordiagnosztikai szakorvos) Koch, Christian A. Juhász Attila (1970-) (szakorvos, klinikai mikrobiológus) Bajnok László (1961-) (belgyógyász) Varga Zsuzsa (1951-) (biokémikus, nephrológus) Seres Ildikó (1954-) (biokémikus) Karányi Zsolt (1961-) (biostatisztikus, bioinformatikus) Magyar Mária Tünde (1970-) (neurológus) Oláh László (1967-) (neurológus) Facskó Andrea (1953-) (szemész) Kappelmayer János (1960-) (laboratóriumi szakorvos) Paragh György (1953-) (belgyógyász)
Pályázati támogatás:	K75199 OTKA TÁMOP 4.2.1/B-091/1/KONV-2010-0007 TÁMOP
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001-es BibID:	BIBFORM061590
Első szerző:	Gharaibeh, Kamel A. (orvos)
Cím:	Desmopression is an effective adjunct treatment for reversing excessive hyponatremia overcorrection / Kamel A. Gharaibeh, Matthew J. Craig, Christian A. Koch, Anna A. Lerant, Tibor Fülöp, Éva Csongrádi
Dátum:	2013
ISSN:	2307-8960
Megjegyzések:	We report a case of a 50-year-old malnourished AfricanAmerican male with hiccups, nausea and vomiting whowas brought to the Emergency Department after repeatedseizures at home. Laboratory evaluations revealedsodium (Na+) 107 mmol/L, unmeasurably low potassium,chloride < 60 mmol/L, bicarbonate of 38 mmol/Land serum osmolality 217 mOsm/kg. Seizures werecontrolled with 3% saline ?. Once nausea was controlledwith iv antiemetics, he developed large volumefree water diuresis with 6 L of dilute urine in 8 h (urineosmolality 40-60 mOsm/kg) and serum sodium rapidlyrose to 126 mmol/L in 12 h. Both intravenous desmopressinand 5% dextrose in water was given to achievea concentrated urine and to temporarily reverse theCASE REPORTWorld J Clin Cases 2013 August 16; 1(5): 155-158ISSN 2307-8960 (online)? 2013 Baishideng. All rights reserved.Online Submissions: http://www.wjgnet.com/esps/wjcc@wjgnet.comdoi:10.12998/wjcc.v1.i5.155WJCC\|www.wjgnet.com 55 August 16, 2013\|Volume 1\|Issue 5\|World Journal ofW J C C Clinical Casesacute rise of sodium, respectively. Serum Na+ was graduallyre-corrected in 2-3 mmol/L daily increments from118 mmol/L until 130 mmol/L. Hypokalemia was slowlycorrected with resultant auto-correction of metabolicalkalosis. The patient discharged home with no neurologicsequaele on the 11th hospital day. In euvolemichyponatremic patients controlling nausea may contributeto unpredictable free water diuresis. The addition ofan antidiuretic hormone analog, such as desmopressincan limit urine output and prevent an unpredictable riseof the serum sodium.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Hyponatremia Hypokalemia Overcorrection Polyuria Antidiuretic hormone Vasopressin Desmopressin Osmotic demyelination syndrome Central pontine myelinolysis
Megjelenés:	World Journal of Clinical Cases. - 1 : 5 (2013), p. 155-158. -
További szerzők:	Craig, Matthew J. (orvos) Koch, Christian A. Lerant, Anna (orvos) Fülöp Tibor (1957-) (kardiológus) Csongrádi Éva (1969-) (szakorvos)
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