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001-es BibID:BIBFORM061589
Első szerző:Arany István (tudományos segédmunkatárs)
Cím:Chronic nicotine exposure exacerbates acute renal ischemic injury / Istvan Arany, Samira Grifoni, Jeb S. Clark, Eva Csongradi, Christine Maric, Luis A. Juncos
Dátum:2011
Megjegyzések:Chronic nicotine exposure exacerbates acute renal ischemicinjury. Am J Physiol Renal Physiol 301: F125?F133, 2011. Firstpublished April 20, 2011; doi:10.1152/ajprenal.00041.2011.?Recentepidemiological reports showed that smoking has a negative impacton renal function and elevates the renal risk not only in the renalpatient but perhaps also in the healthy population. Studies suggestedthat nicotine, a major tobacco alkaloid, links smoking to renal dysfunction.While several studies showed that smoking/chronic nicotineexposure exacerbates the progression of chronic renal diseases, itsimpact on acute kidney injury is virtually unknown. Here, we studiedthe effects of chronic nicotine exposure on acute renal ischemicinjury. We found that chronic nicotine exposure increased the extentof renal injury induced by warm ischemia-reperfusion as evidenced bymorphological changes, increase in plasma creatinine level, and kidneyinjury molecule-1 expression. We also found that chronic nicotineexposure elevated markers of oxidative stress such as nitrotyrosine aswell as malondialdehyde. Interestingly, chronic nicotine exposurealone increased oxidative stress and injury in the kidney withoutmorphological alterations. Chronic nicotine treatment not only increasedreactive oxygen species (ROS) production and injury but alsoexacerbated oxidative stress-induced ROS generation through NADPHoxidase and mitochondria in cultured renal proximal tubulecells. The resultant oxidative stress provoked injury through JNKmediatedactivation of the activator protein (AP)-1 transcription factorin vitro. This mechanism might exist in vivo as phosphorylation ofJNK and its downstream target c-jun, a component of the AP-1transcription factor, is elevated in the ischemic kidneys exposed tochronic nicotine. Our results imply that smoking may sensitize thekidney to ischemic insults and perhaps facilitates progression of acutekidney injury to chronic kidney injury.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
smoking
oxidative stress
JNK/AP-1 activation
Megjelenés:American Journal Of Physiology-Renal Physiology. - 301 : 1 (2011), p. F125-F133. -
További szerzők:Grifoni Samira (tudományos segédmunkatárs) Clark Jeb S. (tudományos segédmunkatárs) Csongrádi Éva (1969-) (szakorvos) Maric Christine (tudományos segédmunkatárs) Juncos Luis A. (orvos)
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