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001-es BibID:	BIBFORM061588
Első szerző:	George, Eric M. (tudományos segédmunkatárs)
Cím:	Induction of Heme Oxygenase-1 Attenuates Placental-Ischemia Induced Hypertension / Eric M. George, Kathy Cockrell, Marietta Aranay, Eva Csongradi, David E. Stec, Joey P. Granger
Dátum:	2011
ISSN:	0194-911X
Megjegyzések:	Recent in vitro studies have reported that heme oxygenase-1 (HO-1) downregulates the angiostaticprotein sFlt-1 from placental villous explants and that the HO-1 metabolites CO and bilirubinnegatively regulates endothelin-1 and reactive oxygen species (ROS). Although sFlt-1, ET-1, andROS have been implicated in the pathophysiology of hypertension during preeclampsia and inresponse to placental ischemia in pregnant rats, it is unknown whether chronic induction of HO-1alters the hypertensive response to placental ischemia. The present study examined the hypothesisthat HO-1 induction in a rat model of placental ischemia would beneficially affect blood pressure,angiogenic balance, superoxide, and ET-1 production in the ischemic placenta. To achieve thisgoal we examined the effects of cobalt protoporphyrin (CoPP), an HO-1 inducer, in the reduceduterine perfusion pressure (RUPP) placental ischemia model and in normal pregnant rats. Inresponse to RUPP treatment, MAP increases 29mmHg (136 ? 7 vs. 106 ? 5 mmHg) which issignificantly attenuated by CoPP (118 ? 5 mmHg). While RUPP treatment causes placental sFlt-1/VEGF ratios to alter significantly to an angiostatic balance (1 ? 0.1 vs 1.27 ? 0.2,), treatment withCoPP causes a significant shift in the ratio to an angiogenic balance (0.68 ? 0.1). Placentalsuperoxide increased in RUPP (952.5 ? 278.8 vs 243.9 ? 70.5 RLU/min/mg), but was significantlyattenuated by HO-1 induction (482.7 ? 117.4 RLU/min/mg). Also, preproendothelin message wassignificantly increased in RUPP, which was prevented by CoPP. These data indicate that HO-1, orits metabolites, are potential therapeutics for the treatment of preeclampsia.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban Placental ischemia; sVEGF R1; preeclampsia; reduced uterine perfusion pressure; ET-1
Megjelenés:	Hypertension. - 57 : 5 (2011), p. 941-948. -
További szerzők:	Cockrell, Kathy (tudományos segédmunkatárs) Aranay, Marietta (tudományos segédmunkatárs) Csongrádi Éva (1969-) (szakorvos) Stec, David E. (tudományos segédmunkatárs) Granger, Joey P. (tudományos segédmunkatárs)
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