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001-es BibID:	BIBFORM105401
035-os BibID:	(cikkazonosító)1003709 (WoS)000868652700001 (Scopus)85139183146
Első szerző:	Kocsis Beatrix (molekuláris biológus)
Cím:	Functional analysis of the bZIP-type transcription factors AtfA and AtfB in Aspergillus nidulans / Beatrix Kocsis, Mi-Kyung Lee, Jae-Hyuk Yu, Tibor Nagy, Lajos Daróczi, Gyula Batta, István Pócsi, Éva Leiter
Dátum:	2022
ISSN:	1664-302X
Megjegyzések:	Transcription factors (TFs) with the basic leucin zipper domain are key elements of the stress response pathways in filamentous fungi. In this study, we functionally characterized the two bZIP type TFs AtfA and AtfB by deletion (Delta) and overexpression (OE) of their encoding genes in all combination: Delta atfA, Delta atfB, Delta atfA Delta atfB, Delta atfAatfBOE, Delta atfBatfAOE, atfAOE, atfBOE and atfAOEatfBOE in Aspergillus nidulans. Based on our previous studies, Delta atfA increased the sensitivity of the fungus to oxidative stress mediated by menadione sodium bisulfite (MSB) and tert-butylhydroperoxide (tBOOH), while Delta atfB was not sensitive to any oxidative stress generating agents, namely MSB, tBOOH and diamide at all. Contrarily, the Delta atfB mutant was sensitive to NaCl, but tolerant to sorbitol. Overexpression of atfB was able to compensate the MSB sensitivity of the Delta atfA mutant. Heavy metal stress elicited by CdCl2 reduced diameter of the atfBOE and atfAOEatfBOE mutant colonies to about 50% of control colony, while the cell wall stress generating agent CongoRed increased the tolerance of the Delta atfA mutant. When we tested the heat stress sensitivity of the asexual spores (conidiospores) of the mutants, we found that conidiospores of Delta atfAatfBOE and Delta atfBatfAOE showed nearly 100% tolerance to heat stress. Asexual development was negatively affected by Delta atfA, while atfAOE and atfAOE coupled with Delta atfB increased the number of conidiospores of the fungus approximately 150% compared to the control. Overexpression of atfB led to a 25% reduction in the number of conidiospores, but increased levels of abaA mRNA and size of conidiospores. Sexual fruiting body (cleistothecium) formation was diminished in the Delta atfA and the Delta atfA Delta atfB mutants, while relatively elevated in the Delta atfB and the Delta atfBatfAOE mutants. Production of the mycotoxin sterigmatocystin (ST) was decreased to undetectable levels in the Delta atfA mutant, yet ST production was restored in the Delta atfA Delta atfB mutant, suggesting that Delta atfB can suppress ST production defect caused by Delta atfA. Levels of ST were also significantly decreased in the Delta atfAatfBOE, Delta atfBatfAOE and atfAOEatfBOE mutants.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk aspergillus nidulans environmental stress conidiospore cleistothecium sterigmatocystin
Megjelenés:	Frontiers in Microbiology. - 13 (2022), p. 1-9. -
További szerzők:	Lee Mi-Kyung Yu Jae-Hyuk Nagy Tibor (1988-) (vegyész) Daróczi Lajos (1965-) (fizikus) Batta Gyula (1979-) (biológus) Pócsi István (1961-) (vegyész) Leiter Éva (1976-) (biológus)
Pályázati támogatás:	NKFIH Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM106701
035-os BibID:	(cikkazonosító)1085891 (WoS)000929068300001 (Scopus)85147698175
Első szerző:	Loi, Martina
Cím:	Advanced mycotoxin control and decontamination techniques in view of an increased aflatoxin risk in Europe due to climate change / Martina Loi, Antonio F. Logrieco, Tünde Pusztahelyi, Éva Leiter, László Hornok, István Pócsi
Dátum:	2023
ISSN:	1664-302X
Megjegyzések:	Aflatoxins are toxic secondary metabolites produced by Aspergillus spp. found in staple food and feed commodities worldwide. Aflatoxins are carcinogenic, teratogenic, and mutagenic, and pose a serious threat to the health of both humans and animals. The global economy and trade are significantly affected as well. Various models and datasets related to aflatoxins in maize have been developed and used but have not yet been linked. The prevention of crop loss due to aflatoxin contamination is complex and challenging. Hence, the set-up of advanced decontamination is crucial to cope with the challenge of climate change, growing population, unstable political scenarios, and food security problems also in European countries. After harvest, decontamination methods can be applied during transport, storage, or processing, but their application for aflatoxin reduction is still limited. Therefore, this review aims to investigate the effects of environmental factors on aflatoxin production because of climate change and to critically discuss the present-day and novel decontamination techniques to unravel gaps and limitations to propose them as a tool to tackle an increased aflatoxin risk in Europe
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk aflatoxin climate change models mycotoxin control decontamination techniques
Megjelenés:	Frontiers in Microbiology. - 13 (2023), p. 1-18. -
További szerzők:	Logrieco, Antonio F. Pusztahelyi Tünde (1969-) (biológus, angol-magyar szakfordító) Leiter Éva (1976-) (biológus) Hornok László Pócsi István (1961-) (vegyész)
Pályázati támogatás:	2018-1.2.1-NKP-2018- 00002 Egyéb TKP2021-EGA-20 810 Egyéb K142801 Egyéb No 952337 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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