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001-es BibID:	BIBFORM066555
Első szerző:	Kocsis Judit (onkológus)
Cím:	HSP70, a kissejtes tüdőrák potenciális biomarkere / Kocsis Judit, Madaras Balázs, Gráf László, Garam Nóra, Maláti Éva, Bártfai Zoltán, Gálffy Gabriella, Tamási Lilla, Döme Balázs, Ostoros Gyula, Prohászka Zoltán, Horváth Zsolt
Dátum:	2015
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:	Magyar Onkológia 59 (2015), p. 30. -
További szerzők:	Madaras Balázs Gráf László Garam Nóra Maláti Éva Bártfai Zoltán (Sopron) Gálffy Gabriella Tamási Lilla Döme Balázs Ostoros Gyula Prohászka Zoltán Horváth Zsolt (1964-) (onkológus, belgyógyász, klinikai farmakológus)
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM066501
035-os BibID:	(WOS)000399000200019 (Scopus)84990855055
Első szerző:	Madaras Balázs
Cím:	Serum heat shock protein 70, as a potential biomarker for small cell lung cancer / Madaras Balázs, Horváth Zsolt, Gráf László, Gálffy Gabriella, Tamási Lilla, Ostoros Gyula, Döme Balázs, Móricz Éva, Bártfai Zoltán, Prohászka Zoltán, Kocsis Judit
Dátum:	2017
ISSN:	1219-4956 1532-2807
Megjegyzések:	AbstractThe 70 kDa heat shock protein (Hsp70) is a highly conservative molecular chaperone, that has important role in cell integrity. Recently considerable amount of data are accumulating on the potential role of Hsp70 in carcinogenesis and tumor progression. Most papers are focusing on intracellular or membrane bound protein, however very limited data exist on serum Hsp70, that can also induce innate and adaptive immune response. Previously we have published data on the correlation between coloretal cancer progression and serum Hsp70 concentration. The objective of this study was to compare the serum Hsp70 level in patients with small cell lung cancer (SCLC n = 70) and age matched healthy controlls (n = 121) and correlate Hsp70 level with other known serum biomarkers (LDH and NSE) of the disease. We found that the serum level of Hsp70 was significantly higher in SCLC patients compared to control subjects (mean value 6.91 vs 2.47 ng/ml, p = 0.001). The highest Hsp70 concentration was measured in stage IV advanced SCLC (Stage IV versus Stage I-III disease: 9.91 vs 4.38 ng/ml, p = 0.003). The serum Hsp70 level correlated with serum LDH (r = 0.426, p < 0,001) and NSE level (r = 0.455, p < 0,001). We found that high serum Hsp70 level predicted unfavorable survival, risk of death within 1 year was more than 3 times higher in patients with high baseline Hsp70 level (HR:3.509, CI: 1.066?11.562; p = 0.039). Our observations indicate that serum Hsp70 could be a valuable diagnostic and prognostic marker in small cell lung cancer.KeywordsSmall cell lung cancerHsp70BiomarkerPrognostic markerTargetDrs Madaras and Horváth contributed equally to this articleThis work was supported by the Debrecen Foundation for Cancer Patients
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Small cell lung cancer Hsp 70 Biomarker Prognostic marker Target
Megjelenés:	Pathology & Oncology Research. - 23 : 2 (2017), p. 377-383. -
További szerzők:	Horváth Zsolt (1964-) (onkológus, belgyógyász, klinikai farmakológus) Gráf László Gálffy Gabriella Tamási Lilla Ostoros Gyula Döme Balázs Móricz Éva Bártfai Zoltán (Sopron) Prohászka Zoltán Kocsis Judit (1967-) (onkológus)
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001-es BibID:	BIBFORM065241
Első szerző:	Molvarec Attila (szülész-nőgyógyász)
Cím:	Circulating anti-heat-shock-protein antibodies in normal pregnancy and preeclampsia / Attila Molvarec, Zoltán Derzsy, Judit Kocsis, Tamás Bőze, Bálint Nagy, Krisztián Balogh, Veronika Makó, László Cervenak, Miklós Mézes, István Karádi, Zoltán Prohászka, János Rigó Jr.
Dátum:	2009
ISSN:	1355-8145
Megjegyzések:	It has been previously reported that circulating anti-heat-shock-protein (Hsp) antibody levels are elevated in cardiovascular disorders. The aim of the present study was to determine circulating antihuman Hsp60, antimycobacterial Hsp65, and antihuman Hsp70 antibody levels in healthy pregnant women and preeclamptic patients and to investigate their relationship to the clinical characteristics of the study subjects, as well as to the markers of inflammation (C-reactive protein (CRP)), endothelial activation (von Willebrand factor antigen), or endothelial injury (fibronectin), oxidative stress (malondialdehyde) and to serum Hsp70 levels. Ninety-three preeclamptic patients and 127 normotensive healthy pregnant women were involved in this case control study. Serum anti-Hsp60, anti-Hsp65, anti-Hsp70, and Hsp70 levels were measured with enzyme-linked immunosorbent assay (ELISA). Serum CRP levels were determined by an autoanalyzer using the manufacturer's kit. Plasma von Willebrand factor antigen levels were quantified by ELISA, while plasma fibronectin concentration by nephelometry. Plasma malondialdehyde levels were measured by the thiobarbituric-acid-based colorimetric assay. For statistical analyses, nonparametric methods were applied. Anti-Hsp60, anti-Hsp65, and anti-Hsp70 antibodies were detected in all of our serum samples. There were no significant differences in serum anti-Hsp60, anti-Hsp65, and anti-Hsp70 antibody levels between the control and preeclamptic groups. Serum levels of Hsp70 and CRP, as well as plasma levels of VWF antigen, fibronectin, and malondialdehyde, were significantly higher in preeclamptic patients than in normotensive healthy pregnant women. Serum anti-Hsp60 antibody levels showed significant correlations with serum anti-Hsp65 antibody levels both in the control and the preeclamptic groups (Spearman R?=?0.55 and 0.59; p?<?0.001, respectively). However, no other relationship was found between clinical features (maternal age, smoking status, parity, body mass index, gestational age at blood draw, systolic and diastolic blood pressure, gestational age at delivery, and fetal birth weight) and measured laboratory parameters of the study subjects and serum anti-Hsp antibody levels in either study group. In conclusion, anti-Hsp60 and anti-Hsp70 antibodies as naturally occurring autoantibodies are present in the peripheral circulation of healthy pregnant women. Nevertheless, humoral immunity against heat shock proteins was not associated with preeclampsia. Further studies are warranted to explore the role of heat shock proteins and immune reactivity to them in the immunobiology of normal pregnancy and preeclampsia.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban circulating anti heatschock protein preeclampsia
Megjelenés:	Cell Stress & Chaperones. - 14 : 5 (2009), p. 491-498. -
További szerzők:	Derzsy Zoltán Kocsis Judit (1967-) (onkológus) Bőze Tamás Nagy Bálint (1956-) (molekuláris genetikus) Balogh Krisztián Makó Veronika Cervenak László Mézes Miklós Karádi István (1952-) (belgyógyász, kardiológus) Prohászka Zoltán Rigó János (1958-) (szülész-nőgyógyász)
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