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1.

001-es BibID:BIBFORM058269
Első szerző:Antal Zsófia (orvos)
Cím:Neurons in the lateral part of the lumbar spinal cord show distinct novel axon trajectories and are excited by short propriospinal ascending inputs / Zs. Antal, L. L. Luz, B. V. Safronov, M. Antal, P. Szűcs
Dátum:2016
ISSN:1863-2653 1863-2661
Megjegyzések:The role of spinal dorsal horn propriospinal connections in nociceptive processing isnot yet established. Recently described, rostrocaudally oriented axon collaterals oflamina I projection and local-circuit neurons (PNs and LCNs) running in thedorsolateral funiculus (DLF) may serve as the anatomical substrate for intersegmentalprocessing. Putative targets of these axons include lateral dendrites of superficialdorsal horn neurons, including PNs, and also neurons in the lateral spinal nucleus(LSN) that are thought to be important integrator units receiving, among others,visceral sensory information. Here we used an intact spinal cord preparation to studyintersegmental connections within the lateral part of the superficial dorsal horn. Wedetected brief monosynaptic and prolonged polysynaptic excitation of lamina I and LSNneurons when stimulating individual dorsal horn neurons located caudally, even inneighbouring spinal cord segments. These connections, however, were infrequent. Wealso revealed that some projection neurons outside the dorsal grey matter and in theLSN have distinct, previously undescribed course of their projection axon. Our findingsindicate that axon collaterals of lamina I PNs and LCNs in the DLF rarely formfunctional connections with other lamina I and LSN neurons and that the majority oftheir targets are on other elements of the dorsal horn. The unique axon trajectories ofneurons in the dorsolateral aspect of the spinal cord, including the LSN do not fit ourpresent understanding of midline axon guidance and suggest that their function anddevelopment differ from the neurons inside lamina I. These findings emphasize theimportance of understanding the connectivity matrix of the superficial dorsal horn inorder to decipher spinal sensory information processing.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
lateral spinal nucleus
propriospinal connection, midline crossing
ipsilateral projection, bilateral projection
3-D reconstruction
Megjelenés:Brain Structure & Function 221 : 4 (2016), p. 2343-2360. -
További szerzők:Luz, Liliana L. Safronov, Boris V. Antal Miklós (1951-) (orvos, anatómus) Szűcs Péter (1974-) (kutatóorvos)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM020417
Első szerző:Antal Zsófia (orvos)
Cím:Lamotrigine effectively blocks synaptic transmission between nociceptive primary afferents and secondary sensory neurons in the rat superficial spinal dorsal horn / Zsófia Antal, Péter Szűcs, Miklós Antal
Dátum:2011
Megjegyzések:It has been demonstrated that in the superficial spinal dorsal horn, Lamotrigine, which is known to block voltage-sensitive Na+ and Ntype Ca2+ channels, depresses neural activities evoked by sustained activation of nociceptive primary afferent fibres. In the present experiments, we study how Lamotrigine exerts its inhibitory effect on spinal nociceptive information-processing mechanisms. We show that Lamotrigine in an in vitro slice preparation effectively blocks synaptic transmission between primary afferents and secondary sensory neurons. Together with the robust increase in the failure rate and reduction in the amplitude of excitatory post-synaptic potentials (EPSPs) evoked by stimulation of nociceptive primary afferents, Lamotrigine causes a marked decrease in the number and amplitude of spontaneous EPSPs and a gradual shift of the resting membrane potential towards hyperpolarization. In addition, Lamotrigine treatment also changes the intrinsic firing pattern of superficial dorsal horn neurons. The results suggest that the effect of Lamotrigine on spinal nociceptive information-processing mechanisms is multiple: it depresses synaptic inputs from nociceptive primary afferents to secondary spinal sensory neurons and also weakens the intrinsic activities of nociceptive spinal neural circuits in the superficial spinal dorsal horn.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény hazai lapban
Egészség- és Környezettudomány
Megjelenés:Interventional Medicine and Applied Science. - 3 : 1 (2011), p. 22-26. -
További szerzők:Szűcs Péter (1974-) (kutatóorvos) Antal Miklós (1951-) (orvos, anatómus)
Pályázati támogatás:TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
A gerincvelő felületes hátsó szarvi neuronhálózatok szerveződése és plaszticitása krónikus gyulladásos és neuropátiás fájdalom állapotokban
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM015671
Első szerző:Hughes, David I.
Cím:P boutons in lamina IX of the rodent spinal cord express high levels of glutamic acid decarboxylase-65 and originate from cells in deep medial dorsal horn / D. I. Hughes, M. Mackie, G. G. Nagy, J. S. Riddell, D. J. Maxwell, G. Szabó, F. Erdélyi, G. Veress, P. Szűcs, M. Antal, A. J. Todd
Dátum:2005
ISSN:0027-8424
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Proceedings Of The National Academy Of Sciences Of The United States Of America. - 102 : 25 (2005), p. 9038-9043. -
További szerzők:Mackie, M. Nagy Gergely György (1976-) (orvos) Riddell, John S. Maxwell, D. J. Szabó Gábor (budapesti orvos) Erdélyi Ferenc Veress Gábor (1971-) (neurobiológus) Szűcs Péter (1974-) (kutatóorvos) Antal Miklós (1951-) (orvos, anatómus) Todd, Andrew J.
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
elektronikus változat
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4.

001-es BibID:BIBFORM060025
Első szerző:Kőszeghy Áron (Ph.D hallgató, élettanász)
Cím:Endocannabinoid signaling modulates neurons of the pedunculopontine nucleus (PPN) via astrocytes. / Áron Kőszeghy, Adrienn Kovács, Tamás Bíró, Péter Szűcs, János Vincze, Zoltán Hegyi, Miklós Antal, Balázs Pál
Dátum:2015
Megjegyzések:The pedunculopontine nucleus (PPN) is known as the cholinergic part of the reticular activating system (RAS) and it plays an important role in transitions of slow-wave sleep to REM sleep and wakefulness. Although both exogenous and endocannabinoids affect sleep, the mechanism of endocannabinoid neuromodulation has not been characterized at cellular level in the PPN. In this paper, we demonstrate that both neurons and glial cells from the PPN respond to cannabinoid type 1 (CB1) receptor agonists. The neuronal response can be depolarization or hyperpolarization, while astrocytes exhibit more frequent calcium waves. All these effects are absent in CB1 gene-deficient mice. Blockade of the fast synaptic neurotransmission or neuronal action potential firing does not change the effect on the neuronal membrane potential significantly, while inhibition of astrocytic calcium waves by thapsigargin diminishes the response. Inhibition of group I metabotropic glutamate receptors (mGluRs) abolishes hyperpolarization, whereas blockade of group II mGluRs prevents depolarization. Initially active neurons and glial cells display weaker responses partially due to the increased endocannabinoid tone in their environment. Taken together, we propose that cannabinoid receptor stimulation modulates PPN neuronal activity in the following manner: active neurons may elicit calcium waves in astrocytes via endogenous CB1 receptor agonists. Astrocytes in turn release glutamate that activates different metabotropic glutamate receptors of neurons and modulate PPN neuronal activity.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Endocannabinoid
Pedunculopontine nucleus
CB1 receptor
Neuromodulation
Astrocyte
Metabotropic glutamate receptor
Megjelenés:Brain structure and function 220 : 5 (2015), p. 3023-3041. -
További szerzők:Kovács Adrienn (1989-) (molekuláris biológus) Bíró Tamás (1968-) (élettanász) Szűcs Péter (1974-) (kutatóorvos) Vincze János (1988-) (orvos) Hegyi Zoltán (1983-) (molekuláris biológus) Antal Miklós (1951-) (orvos, anatómus) Pál Balázs (1975-) (élettanász)
Internet cím:Szerző által megadott URL
DOI
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5.

001-es BibID:BIBFORM062728
Első szerző:Kovács Adrienn (molekuláris biológus)
Cím:Direct presynaptic and indirect astrocyte-mediated mechanisms both contribute to endocannabinoid signaling in the pedunculopontine nucleus of mice / Kovács A., Bordás Cs., Bíró T., Hegyi Z., Antal M., Szücs P., Pál B.
Dátum:2017
ISSN:1863-2653 1863-2661
Megjegyzések:The pedunculopontine nucleus (PPN), a cholinergic nucleus of the reticular activating system, is known to be involved in the regulation of sleep and wakefulness. Endogenous and exogenous cannabinoids, either by systemic or local administration to the pedunculopontine nucleus can both influence sleep. We previously demonstrated that activation of astrocytes by cannabinoid type 1 (CB1) receptor agonists was able to modulate the membrane potential of PPN neurons, even in the presence of blockers of fast synaptic neurotransmission. In the present work we provide evidence that synaptic inputs of PPN neurons are also affected by activation of presynaptic and astrocytic CB1 receptors.Using slice electrophysiology combined with calcium imaging, optogenetics and immunohistochemistry, we revealed a direct presynaptic inhibitory action on inhibitory postsynaptic currents, along with a mild increase of excitatory postsynaptic currents during CB1 receptor stimulation. Besides inhibition of excitatory and inhibitory neurotransmission through stimulation of presynaptic CB1 receptors, astrocyte- and mGluR-dependent tonic inhibition and excitation also developed. The mild stimulatory action of CB1 receptor activation on excitatory neurotransmission is the combination of astrocyte-dependent tonic excitation on excitatory neurons and the canonical presynaptic CB1 receptor activation and consequential inhibition of excitatory synaptic neurotransmission, whereas the astrocyte-dependent stimulatory action was not observed on inhibitory neurotransmission within the PPN.Our findings demonstrate that endocannabinoids act in the PPN via a dual pathway, consisting of a direct presynaptic and an indirect, astrocyte-mediated component, regulating synaptic strength and neuronal activity via independent mechanisms.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
pedunculopontine nucleus
CB1 receptor
optogenetics
astrocyte
neuromodulation
Megjelenés:Brain Structure & Function 222 : 1 (2017), p. 247-266. -
További szerzők:Bordás Csilla Bíró Tamás (1968-) (élettanász) Hegyi Zoltán (1983-) (molekuláris biológus) Antal Miklós (1951-) (orvos, anatómus) Szűcs Péter (1974-) (kutatóorvos) Pál Balázs (1975-) (élettanász)
Pályázati támogatás:Nemzeti Agykutatási Program KTIA_13_NAP-A-I/10
Egyéb
Nemzeti Agykutatási Program KTIA_NAP_13-1-2013-0001
Egyéb
Nemzeti Agykutatási Program KTIA_NAP_13-2-2014-0005
Egyéb
MTA-TKI 242
MTA
TÁMOP-4.2.2.B-15/1/KONV-2015-0001
TÁMOP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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6.

001-es BibID:BIBFORM020384
Első szerző:Papachatzaki, Maria Martha
Cím:RGS9-2 modulates nociceptive behaviour and opioid-mediated synaptic transmission in the spinal dorsal horn / Maria Martha Papachatzaki, Zsófia Antal, Dimitra Terzi, Péter Szücs, Venetia Zachariou, Miklós Antal
Dátum:2011
ISSN:0304-3940
Megjegyzések:The regulator of G protein signaling 9-2 (RGS9-2) is a constituent of G protein-coupled receptor (GPCR) macromolecular complexes with a major role in regulation of GPCR activity in the central nervous system. Previous in situ hybridization and Western blot studies revealed that RGS9-2 is expressed in the superficial dorsal horn of the spinal cord. In the present study, we monitored tail withdrawal latencies to noxious thermal stimuli and performed in vitro whole-cell patch clamp electrophysiological recordings from neurons in lamina II of the spinal dorsal horn to examine the role of RGS9-2 in the dorsal horn of the spinal cord in nociceptive behaviours and opiate mediated modulation of synaptic transmission. Our findings obtained from RGS9 knockout mice indicate that the lack of RGS9-2 protein decreases sensitivity to thermal stimuli and to the analgesic actions of morphine in the tail immersion paradigm. This modulatory role of RGS9-2 on opiate-mediated responses was further supported by electrophysiological studies showing that hyperpolarization of neurons in lamina II of the spinal dorsal horn evoked by application of DAMGO ([d-Ala2, N-MePhe4, Gly-ol]-enkephalin, a mu opioid receptor agonist) was diminished in RGS9 knockout mice. The results indicate that RGS9-2 enhances the effect of morphine and may play a crucial role in opiate-mediated analgesic mechanisms at the level of the spinal cord.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Egészség- és Környezettudomány
Megjelenés:Neuroscience Letters. - 501 : 1 (2011), p. 31-34. -
További szerzők:Antal Zsófia (1985-) (orvos) Terzi, Dimitra Szűcs Péter (1974-) (kutatóorvos) Zachariou, Venetia Antal Miklós (1951-) (orvos, anatómus)
Pályázati támogatás:TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
A gerincvelő felületes hátsó szarvi neuronhálózatok szerveződése és plaszticitása krónikus gyulladásos és neuropátiás fájdalom állapotokban
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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7.

001-es BibID:BIBFORM029097
Első szerző:Papp Ildikó (biológus)
Cím:Hyperpolarization-activated and cyclic nucleotide-gated cation channel subunit 2 ion channels modulate synaptic transmission from nociceptive primary afferents containing substance P to secondary sensory neurons in laminae I-IIo of the rodent spinal dorsal horn / Papp I., Szűcs P., Holló K., Erdélyi F., Szabó G., Antal M.
Dátum:2006
Megjegyzések:We have previously demonstrated that hyperpolarization-activated and cyclic nucleotide-gated cation channel subunit 2 (HCN2) is expressed by terminals of peptidergic nociceptive primary afferents in laminae I-IIo of the rat spinal dorsal horn. In this study, we investigated the possible neurotransmitters and postsynaptic targets of these HCN2-expressing primary afferent terminals in the superficial spinal dorsal horn by using immunocytochemical methods. We demonstrated that HCN2 widely colocalizes with substance P (SP), and that HCN2-positive terminals that are also immunoreactive for SP form serial close appositions with dendrites and perikarya of neurokinin 1 receptor-immunoreactive neurons. It was also found that HCN2-immunoreactive terminals are frequently apposed to neurons that are immunoreactive for calbindin, mu-opioid receptor and the alfa-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor subunit GluR2, markers for excitatory interneurons. Investigating HCN2 immunoreactivity in glutamic acid decarboxylase 65-green fluorescent protein transgenic mice, we found that HCN2-positive terminals occasionally also contact cells that contain an isoform of glutamic acid decarboxylase (glutamic acid decarboxylase 65), a marker for GABAergic inhibitory neurons. Application of ZD7288, an antagonist of HCN channels, onto neurons that were recorded in spinal cord slices with whole-cell patch-clamp electrodes reduced the number of monosynaptic excitatory postsynaptic potentials evoked by electrical stimulation of primary afferents at nociceptive intensities. The results suggest that HCN2 may contribute to the modulation of membrane excitability of SP-containing nociceptive primary afferent terminals, may increase the reliability of synaptic transmission from primary afferents to secondary sensory neurons and thus may play a role in the fine-tuning of pain transmission from nociceptive primary afferents to neurons in the spinal dorsal horn.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:European Journal of Neuorscience. - 24 : 5 (2006), p. 1341-1352. -
További szerzők:Szűcs Péter (1974-) (kutatóorvos) Holló Krisztina (1967-) (vegyész) Erdélyi Ferenc Szabó Gábor (budapesti orvos) Antal Miklós (1951-) (orvos, anatómus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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8.

001-es BibID:BIBFORM029092
Első szerző:Szűcs Péter (kutatóorvos)
Cím:Neurons with distinctive firing patterns, morphology and distribution in laminae V-VII of the neonatal rat lumbar spinal cord / Szűcs P., Odeh F., Szokol K., Antal M.
Dátum:2003
Megjegyzések:It is generally accepted that neurons in the ventral spinal grey matter, a substantial proportion of which can be regarded as constituents of the spinal motor apparatus, receive and integrate synaptic inputs arising from various peripheral, spinal and supraspinal sources. Thus, a profound knowledge concerning the integrative properties of interneurons in the spinal ventral grey matter appears to be essential for a fair understanding of operational principles of spinal motor neural assemblies. Using the whole cell patch clamp configuration in a correlative physiological and morphological experimental approach, here we demonstrate that the intrinsic membrane properties of neurons vary widely in laminae V-VII of the ventral grey matter of the neonatal rat lumbar spinal cord. Based on their firing patterns in response to depolarizing current steps, we have classified the recorded neurons into four categories: 'phasic', 'repetitive', 'single' and 'slow'. Neurons with firing properties characteristic of the 'phasic', 'repetitive' and 'single' cells have previously been reported also in the superficial and deep spinal dorsal horn, but this is the first account in the literature in which 'slow' neurons have been recovered and described in the spinal cord. The physiological heterogeneity in conjunction with the morphological correlation and distribution of neurons argues that different components of motor neural assemblies in the spinal ventral grey matter possess different signal processing characteristics.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:European Journal of Neuroscience. - 17 : 3 (2003), p. 537-544. -
További szerzők:Odeh, Francis Szokol Karolina Antal Miklós (1951-) (orvos, anatómus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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9.

001-es BibID:BIBFORM001430
Első szerző:Wéber Ildikó (biológus, neurobiológus)
Cím:Neurotransmitter systems of commissural interneurons int he lumbar spinal cord of neonatal rats / Wéber I., Veress G., Szűcs P., Antal M., Birinyi A.
Dátum:2007
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Brain Research. - 1178 (2007), p. 65-72. -
További szerzők:Veress Gábor (1971-) (neurobiológus) Szűcs Péter (1974-) (kutatóorvos) Antal Miklós (1951-) (orvos, anatómus) Birinyi András (1960-) (anatómus, neurobiológus)
Pályázati támogatás:046121
OTKA
032075
OTKA
T032075
OTKA
Internet cím:elektronikus változat
DOI
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