Találati lista | Tudóstér

001-es BibID:	BIBFORM058269
Első szerző:	Antal Zsófia (orvos)
Cím:	Neurons in the lateral part of the lumbar spinal cord show distinct novel axon trajectories and are excited by short propriospinal ascending inputs / Zs. Antal, L. L. Luz, B. V. Safronov, M. Antal, P. Szűcs
Dátum:	2016
ISSN:	1863-2653 1863-2661
Megjegyzések:	The role of spinal dorsal horn propriospinal connections in nociceptive processing isnot yet established. Recently described, rostrocaudally oriented axon collaterals oflamina I projection and local-circuit neurons (PNs and LCNs) running in thedorsolateral funiculus (DLF) may serve as the anatomical substrate for intersegmentalprocessing. Putative targets of these axons include lateral dendrites of superficialdorsal horn neurons, including PNs, and also neurons in the lateral spinal nucleus(LSN) that are thought to be important integrator units receiving, among others,visceral sensory information. Here we used an intact spinal cord preparation to studyintersegmental connections within the lateral part of the superficial dorsal horn. Wedetected brief monosynaptic and prolonged polysynaptic excitation of lamina I and LSNneurons when stimulating individual dorsal horn neurons located caudally, even inneighbouring spinal cord segments. These connections, however, were infrequent. Wealso revealed that some projection neurons outside the dorsal grey matter and in theLSN have distinct, previously undescribed course of their projection axon. Our findingsindicate that axon collaterals of lamina I PNs and LCNs in the DLF rarely formfunctional connections with other lamina I and LSN neurons and that the majority oftheir targets are on other elements of the dorsal horn. The unique axon trajectories ofneurons in the dorsolateral aspect of the spinal cord, including the LSN do not fit ourpresent understanding of midline axon guidance and suggest that their function anddevelopment differ from the neurons inside lamina I. These findings emphasize theimportance of understanding the connectivity matrix of the superficial dorsal horn inorder to decipher spinal sensory information processing.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban lateral spinal nucleus propriospinal connection, midline crossing ipsilateral projection, bilateral projection 3-D reconstruction
Megjelenés:	Brain Structure & Function 221 : 4 (2016), p. 2343-2360. -
További szerzők:	Luz, Liliana L. Safronov, Boris V. Antal Miklós (1951-) (orvos, anatómus) Szűcs Péter (1974-) (kutatóorvos)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM020417
Első szerző:	Antal Zsófia (orvos)
Cím:	Lamotrigine effectively blocks synaptic transmission between nociceptive primary afferents and secondary sensory neurons in the rat superficial spinal dorsal horn / Zsófia Antal, Péter Szűcs, Miklós Antal
Dátum:	2011
Megjegyzések:	It has been demonstrated that in the superficial spinal dorsal horn, Lamotrigine, which is known to block voltage-sensitive Na+ and Ntype Ca2+ channels, depresses neural activities evoked by sustained activation of nociceptive primary afferent fibres. In the present experiments, we study how Lamotrigine exerts its inhibitory effect on spinal nociceptive information-processing mechanisms. We show that Lamotrigine in an in vitro slice preparation effectively blocks synaptic transmission between primary afferents and secondary sensory neurons. Together with the robust increase in the failure rate and reduction in the amplitude of excitatory post-synaptic potentials (EPSPs) evoked by stimulation of nociceptive primary afferents, Lamotrigine causes a marked decrease in the number and amplitude of spontaneous EPSPs and a gradual shift of the resting membrane potential towards hyperpolarization. In addition, Lamotrigine treatment also changes the intrinsic firing pattern of superficial dorsal horn neurons. The results suggest that the effect of Lamotrigine on spinal nociceptive information-processing mechanisms is multiple: it depresses synaptic inputs from nociceptive primary afferents to secondary spinal sensory neurons and also weakens the intrinsic activities of nociceptive spinal neural circuits in the superficial spinal dorsal horn.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény hazai lapban Egészség- és Környezettudomány
Megjelenés:	Interventional Medicine and Applied Science. - 3 : 1 (2011), p. 22-26. -
További szerzők:	Szűcs Péter (1974-) (kutatóorvos) Antal Miklós (1951-) (orvos, anatómus)
Pályázati támogatás:	TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP A gerincvelő felületes hátsó szarvi neuronhálózatok szerveződése és plaszticitása krónikus gyulladásos és neuropátiás fájdalom állapotokban
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM020384
Első szerző:	Papachatzaki, Maria Martha
Cím:	RGS9-2 modulates nociceptive behaviour and opioid-mediated synaptic transmission in the spinal dorsal horn / Maria Martha Papachatzaki, Zsófia Antal, Dimitra Terzi, Péter Szücs, Venetia Zachariou, Miklós Antal
Dátum:	2011
ISSN:	0304-3940
Megjegyzések:	The regulator of G protein signaling 9-2 (RGS9-2) is a constituent of G protein-coupled receptor (GPCR) macromolecular complexes with a major role in regulation of GPCR activity in the central nervous system. Previous in situ hybridization and Western blot studies revealed that RGS9-2 is expressed in the superficial dorsal horn of the spinal cord. In the present study, we monitored tail withdrawal latencies to noxious thermal stimuli and performed in vitro whole-cell patch clamp electrophysiological recordings from neurons in lamina II of the spinal dorsal horn to examine the role of RGS9-2 in the dorsal horn of the spinal cord in nociceptive behaviours and opiate mediated modulation of synaptic transmission. Our findings obtained from RGS9 knockout mice indicate that the lack of RGS9-2 protein decreases sensitivity to thermal stimuli and to the analgesic actions of morphine in the tail immersion paradigm. This modulatory role of RGS9-2 on opiate-mediated responses was further supported by electrophysiological studies showing that hyperpolarization of neurons in lamina II of the spinal dorsal horn evoked by application of DAMGO ([d-Ala2, N-MePhe4, Gly-ol]-enkephalin, a mu opioid receptor agonist) was diminished in RGS9 knockout mice. The results indicate that RGS9-2 enhances the effect of morphine and may play a crucial role in opiate-mediated analgesic mechanisms at the level of the spinal cord.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Egészség- és Környezettudomány
Megjelenés:	Neuroscience Letters. - 501 : 1 (2011), p. 31-34. -
További szerzők:	Antal Zsófia (1985-) (orvos) Terzi, Dimitra Szűcs Péter (1974-) (kutatóorvos) Zachariou, Venetia Antal Miklós (1951-) (orvos, anatómus)
Pályázati támogatás:	TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP A gerincvelő felületes hátsó szarvi neuronhálózatok szerveződése és plaszticitása krónikus gyulladásos és neuropátiás fájdalom állapotokban
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: