Találati lista | Tudóstér

001-es BibID:	BIBFORM014423
Első szerző:	Munne, Pauliina M.
Cím:	Splitting placodes : effects of bone morphogenetic protein and Activin on the patterning and identity of mouse incisors / Munne, Pauliina M., Felszeghy Szabolcs, Jussila, Maria, Suomalainen, Marika, Thesleff, Irma, Jernvall, Jukka
Dátum:	2010
ISSN:	1520-541X
Megjegyzések:	The single large rodent incisor in each jaw quadrant is evolutionarily derivedfrom a mammalian ancestor with many small incisors. The embryonic placode givingrise to the mouse incisor is considerably larger than the molar placode, and thequestion remains whether this large incisor placode is a developmental requisiteto make a thick incisor. Here we used in vitro culture system to experiment withthe molecular mechanism regulating tooth placode development and how mice havethick incisors. We found that large placodes are prone to disintegration andformation of two to three small incisor placodes. The balance between one largeor multiple small placodes was altered through the regulation of bonemorphogenetic protein (BMP) and Activin signaling. Exogenous Noggin, whichinhibits BMP signaling, or exogenous Activin cause the development of two tothree incisors. These incisors were more slender than normal incisors.Additionally, two inhibitor molecules, Sostdc1 and Follistatin, which regulatethe effects of BMPs and Activin and have opposite expression patterns, are likelyto be involved in the incisor placode regulation in vivo. Furthermore, inhibitionof BMPs by recombinant Noggin has been previously suggested to cause a change inthe tooth identity from the incisor to the molar. This evidence has been used tosupport a homeobox code in determining tooth identity. Our work provides analternative interpretation, where the inhibition of BMP signaling can lead tosplitting of the large incisor placode and the formation of partly separateincisors, thereby acquiring molar-like morphology without a change in toothidentity.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban 0 (Bone Morphogenetic Proteins) 0 (Carrier Proteins) 0 (Follistatin) 0 (Sostdc1 protein, mouse) 104625-48-1 (Activins) 148294-77-3 (noggin protein) Activins/genetics/metabolism/physiology Animals Body Patterning Bone Morphogenetic Proteins/genetics/metabolism/physiology Carrier Proteins/metabolism Embryo, Mammalian/metabolism Embryonic Development Follistatin/metabolism/physiology Incisor/anatomy & histology/*embryology külföldön készült közlemény Mice Signal Transduction
Megjelenés:	Evolution & Development. - 12 (2010), p. 383-392. -
További szerzők:	Felszeghy Szabolcs Béla (1972-) (fogorvos, anatómus, kötőszövetbiológus) Jussila, Maria Suomalainen, Marika Thesleff, Irma Jernvall, Jukka
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
Borító:
Saját polcon: