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001-es BibID:BIBFORM015609
035-os BibID:12176806
Első szerző:Lapvetelainen, T.
Cím:Lifelong voluntary joint loading increases osteoarthritis in mice housing adeletion mutation in type II procollagen gene, and slightly also innon-transgenic mice / T. Lapveteläinen, M. M. Hyttinen, A-M. Säämänen, T. Långsjö, J. Sahlman, S. Felszeghy, E. Vuorio, H. J. Helminen
Dátum:2002
ISSN:0003-4967 (Linking)
Megjegyzések:OBJECTIVES: To investigate the effects of voluntary running on the incidence and severity of osteoarthritis (OA) and associated changes in cartilage matrix andsubchondral bone in a transgenic Del1 mouse model for OA. METHODS: Del1 mice andtheir non-transgenic littermate controls were housed from the age of 5-6 weeks to15 months in individual cages with running wheels. The running activity of eachmouse was monitored for the entire 12 month period. Additional Del1 and controlmice were housed in individual cages without running wheels. At the end of theexperiment the severity of OA was evaluated by light microscopy, and thearticular cartilage matrix changes by digital densitometry and quantitativepolarised light microscopy. RESULTS: Lifelong voluntary running increased theincidence and severity of OA significantly in Del1 mice (transgenic runners), andslightly also in non-transgenic runners. Severe OA changes increased from 39% intransgenic non-runners to 90% in transgenic runners (p=0.006) in lateral tibialcondyles, and from 24% to 80% (p=0.013) in lateral femoral condyles,respectively. The proteoglycan content of articular cartilage was reduced intransgenic runners in comparison with transgenic non-runners (p=0.0167), but asimilar effect was not seen in non-transgenic runners compared withnon-transgenic non-runners. No attributable differences were seen in the collagennetwork of articular cartilage or in the subchondral bone between any of thegroups. CONCLUSION: The Del1 mutation has earlier been shown to disturb theassembly of the cartilage collagen network and thereby increase the incidence andseverity of OA with age. In this study, voluntary running was shown to increasefurther cartilage damage in the lateral compartments of the knee. This suggeststhat articular cartilage in Del1 mice is less resistant to physical loading thanin control mice. Despite severe OA lesions in the knee joint at the age of 15months, Del1 mice continued to run voluntarily 2-3 km every night.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
0 (Collagen Type II)
0 (Proteoglycans)
Animals
Cartilage, Articular/metabolism/pathology/*physiopathology
Case-Control Studies
Collagen Type II/*genetics/metabolism
Extracellular Matrix/metabolism
*Gene Deletion
Hindlimb
Male
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Mice, Transgenic
Models, Animal
Motor Activity
Osteoarthritis/metabolism/pathology/*physiopathology
Proteoglycans/analysis
Statistics, Nonparametric
külföldön készült közlemény
Stress, Mechanical
Megjelenés:Annals of the rheumatic diseases. - 61 : 9 (2002), p. 810-817. -
További szerzők:Hyttinen, M. M. Saamanen, A. M. Langsjo, T. Sahlman, J. Felszeghy Szabolcs Béla (1972-) (fogorvos, anatómus, kötőszövetbiológus) Vuorio, E. Helminen, H. J.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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