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001-es BibID:	BIBFORM004806
Első szerző:	Harangi Mariann (belgyógyász, endokrinológus)
Cím:	Association between human paraoxonase 1 activity and intima-media thickness in subjects under 55 years of age with carotid artery disease / Mariann Harangi, Ildiko Seres, Maria T. Magyar, Istvan Csipo, Sandor Sipka, Attila Valikovics, Laszlo Csiba, Daniel Bereczki, Gyorgy Paragh
Dátum:	2008
Megjegyzések:	Human serum paraoxonase (PON1) protects lipoproteins against oxidation by hydrolyzing lipid peroxides in oxidized low-density lipoprotein (oxLDL); therefore, it may protect against atherosclerosis. PON1 activity and polymorphisms have been inconsistently associated with carotid artery disease. The goal of this study was to clarify the role of PON1 activity and phenotype on carotid artery disease and its correlation with some inflammatory and immune markers in subjects under 55 years with early-onset carotid atherosclerosis. Methods: Sixty patients with occlusive carotid artery disease and 30 healthy controls were enrolled. Intimamedia thickness (IMT) was measured by high-resolution ultrasound of both common carotid arteries. Anti-oxLDL antibody levels were determined by ELISA. Results: In the whole study population we found a negative correlation between PON1 activity and IMT (r = -0.27, p = 0.011), and between saltstimulated PON1 activity and IMT (r = -0.24, p = 0.02). Both PON1 activity and salt-stimulated PON1 activity negatively correlated with anti-oxLDL levels (r = -0.28, p = 0.008; r = -0.26, p = 0.01). PON1 activity was lower in patients compared to controls; however, the difference was not significant.PON1 phenotype distribution of patients and controls did not differ significantly. Conclusion: The importance of PON1 activity as a redictive risk factor for early-onset occlusive carotid artery disease should be assessed in future studies.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Paraoxonase Intima-media thickness egyetemen (Magyarországon) készült közlemény
Megjelenés:	Cerebrovascular Diseases 25 : 1-2 (2008), p. 122-128. -
További szerzők:	Seres Ildikó (1954-) (biokémikus) Magyar Mária Tünde (1970-) (neurológus) Csípő István (1953-) (vegyész) Sipka Sándor (1945-) (laboratóriumi szakorvos) Valikovics Attila Csiba László (1952-) (neurológus, pszichiáter) Bereczki Dániel (1960-) (neurológus) Paragh György (1953-) (belgyógyász)
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001-es BibID:	BIBFORM004803
Első szerző:	Kónya József (szakorvos, klinikai mikrobiológus)
Cím:	Severity of carotid atherosclerosis unrelated to chlamydia pneumoniae infection in acute ischemic stroke patients : a clinicopathological Study / József Kónya, Sándor Molnár, Mária T. Magyar, Csilla C. Szekeres, Levente Kerényi, László Csiba
Dátum:	2008
Megjegyzések:	Both clinical and pathological alterations of the carotid arteries were correlated with Chlamydia pneumoniae infection in 67 acute ischemic stroke patients with severe neurological symptoms. Methods: In the clinical study, intima-media thickness (IMT) of the common carotid arteries was determined in vivo by B-mode ultrasound measurement and C. pneumoniae- specific IgG and IgA responses were detected. In the pathological study, the absolute wall thickness of the common, internal and external carotid arteries was measured postmortem in specimens obtained at the autopsy of patients who died due to complications of acute stroke. In the atherosclerotic plaques of the autopsy specimens, C. pneumoniae genomic DNA was detected by polymerase chain reaction amplification. Results: The Spearman's rho correlation coefficient of IMT with the average wall thickness of the common, internal and external carotid arteries was 0.51 (p = 0.002), 0.34 (p = 0.052) and 0.58 (p ! 0.001), respectively. Anti- C. pneumoniae IgG and IgA anti-bodies were detected in 43 (73%) and 29 (49%) patients, but neither antibody marker correlated with IMT (median: 0.91 mm in IgG positives vs. 0.90 mm in IgG negatives, p = 0.86; 0.88 mm in IgA positives vs. 0.90 mm in IgA negatives, p = 0.53). The presence of C. pneumoniae DNA was detected in the carotid plaques of 21 (54%) of the 39 tested patients, independently of either IMT values or the average wall thickness of all carotid arteries. Conclusions: In acute ischemic stroke patients, C. pneumoniae infection was frequently detected in the arteriosclerotic plaques of the carotid arteries but it did not correlate with the severity of carotid arteriosclerosis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Chlamydia pneumoniae Carotid arteries carotid ultrasonography Ischemic stroke
Megjelenés:	Cerebrovascular Diseases 25 : 1-2 (2008), p. 170-175. -
További szerzők:	Molnár Sándor (1973-) (neurológus) Magyar Mária Tünde (1970-) (neurológus) Szekeres Csilla Cecília (1980-) (orvos) Kerényi Levente Csiba László (1952-) (neurológus, pszichiáter)
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001-es BibID:	BIBFORM029269
Első szerző:	Magyar Mária Tünde (neurológus)
Cím:	Transcranial Doppler monitoring in hypertensive patients during physical exercise / Magyar, M. T., Valikovics, A., Bereczki, D., Ficzere, A., Czuriga, I., Csiba, L.
Dátum:	2001
ISSN:	1015-9770
Megjegyzések:	To evaluate the diagnostic value of a combined method, i.e. ergometer cycling with continuous bilateral transcranial Doppler monitoring (TCD) to detect cerebral hemodynamic abnormalities in recently diagnosed hypertensive patients. METHODS: 30 neurologically symptom-free, nontreated patients with essential hypertension and 30 age- and sex-matched controls were studied. Carotid ultrasound, resting ECG and blood parameters were investigated. Cycling ergometry was performed according to the WHO protocol. Blood pressure, heart rate, end-tidal CO2 (etCO2) and bilateral middle cerebral artery (MCA) blood flow velocity (MV) were monitored. RESULTS: At rest, MV in the MCA did not differ significantly between controls and hypertensive subjects. MV continuously increased in controls until the end of loading whereas a plateau was reached at 4 min in hypertensive subjects. During 6 min of cycling, the time course of absolute values of MV in the MCA and that of the changes in the ratio of mean velocity/end-tidal CO2 (DeltaMV/DeltaetCO2) differed significantly between hypertensive subjects and controls (p = 0.03 and p = 0.02, respectively). CONCLUSION: Ergometer cycling combined with TCD revealed altered vasoreactivity, therefore this may be a sensitive method for the detection of early hemodynamic impairment in nontreated hypertensive subjects.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Cerebrovascular diseases. - 12 : 3 (2001), p. 186-191. -
További szerzők:	Valikovics Attila Bereczki Dániel (1960-) (neurológus) Ficzere Andrea (1967-) (neurológus) Czuriga István (1948-2018) (kardiológus) Csiba László (1952-) (neurológus, pszichiáter)
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001-es BibID:	BIBFORM001509
Első szerző:	Zsuga Judit (neurológus, pszichoterapeuta, egészségügyi szakmanager)
Cím:	Serum asymmetric dimethylarginine negatively correlates with intima-media thickness in early-onset atherosclerosis / Judit Zsuga, Janos Török, Mária Tünde Magyar, Attila Valikovics, Rudolf Gesztelyi, Sándor Kéki, Laszló Csiba, Miklos Zsuga, Dániel Bereczki
Dátum:	2007
Megjegyzések:	Asymmetric dimethylarginine (ADMA) assumes a significant role in atherosclerosis by inhibiting the endothelial nitric oxide synthase (eNOS). Moreover, ADMA inhibits the inducible NOS (iNOS), the isoform that triggers atherosclerosis via peroxynitrite formation. Therefore, we investigated whether ADMA is a risk or protective factor in the atherosclerotic process. Intima-media thickness (IMT) of the common carotid artery, a surrogate for vascular diseases,was chosen as the outcome variable of interest. Methods: Sixty patients younger than 55 years having at least 30% stenosis of the internal carotid artery and 30 age- and gendermatched controls were recruited at a community-based neurosonological laboratory. We investigated relatively young patients to circumvent the confounding effect age has in the development of atherosclerosis. Results: The IMT showed a negative correlation with ADMA upon analysis of the pooled data (Spearman correlation coefficient -0.300, p = 0.0041) and the atherosclerotic stratum (Spearman correlation coefficient -0.323, p = 0.012). A multiple linear regression model containing all determinant factors of IMT previously identified by simple regression was used to further quantify the relationship between IMT and ADMA. Thenegative association between IMT and ADMA remained statistically significant ( beta: -0.510, CI: -0.894, -0.127; p = 0.010), furthermore it was even stronger in the atherosclerotic stratum( beta : -0.67, CI: -1.16, -0.18; p = 0.008). Conclusions: A minimal increase in ADMA concentration may be protective by inhibiting iNOS but not eNOS in states where iNOS is induced, e.g. inflammation accompanying atherosclerosis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban atherosclerosis inflammation carotid arteries vascular risk factors nitric oxide synthase
Megjelenés:	Cerebrovascular Diseases 23 : 5-6 (2007), p. 388-394. -
További szerzők:	Török János Magyar Mária Tünde (1970-) (neurológus) Valikovics Attila Gesztelyi Rudolf (1969-) (kísérletes farmakológus) Kéki Sándor (1964-) (polimer kémikus) Csiba László (1952-) (neurológus, pszichiáter) Zsuga Miklós (1944-) (polimer kémikus) Bereczki Dániel (1960-) (neurológus)
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