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1.

001-es BibID:BIBFORM020965
035-os BibID:PMID:16788247
Első szerző:Balla József (belgyógyász, nephrológus)
Cím:Serum levels of platelet released CD40 ligand are increased in early onset occlusive carotid artery disease / József Balla, Mária Tünde Magyar, Dániel Bereczki, Attila Valikovics, Emőke Nagy, Erika Barna, András Pál, György Balla, László Csiba, György Blaskó
Dátum:2006
Megjegyzések:Soluble CD40 ligand (sCD40L) has been suggested as a key mediator between inflammation and atherosclerosis, and the CD40-CD40L interaction has a role in atherosclerotic lesion progression. We evaluated if platelet released serum sCD40L and sCD40 levels differ between patients with early onset occlusive carotid artery disease and age-matched controls. METHODS: sCD40L and sCD40 levels were measured in serum samples of 60 patients with occlusive carotid artery disease and 30 age-matched controls using ELISA. Degree of stenosis of the internal carotid artery (ICA), and intima-media thickness (IMT) in the common carotid artery were measured by high resolution ultrasound. Values are given as mean +/- SD. RESULTS: Mean age was 50.9 +/- 3.5 and 50.1 +/- 3.5 years in the patient and control groups. IMT was significantly thicker in patients than in controls (0.89 +/- 0.14 vs. 0.78 +/-0.12 mm, p=0.0003). Serum levels of sCD40L were significantly higher (6.9 +/- 5 vs. 4.5 +/- 3.0 ng/mL, p=0.038) in patients, whereas sCD40 did not differ significantly between patients and controls (85 +/- 56.9 vs. 79.3 +/- 18.7 pg/mL, p=0.34). IMT did not correlate with sCD40L or sCD40 levels (R=-0.03, p=0.77; and R=0.109, p=0.308, respectively). CONCLUSIONS: sCD40L but not sCD40 levels are significantly higher in patients with occlusive carotid artery disease. Platelet derived sCD40L may be a key mediator among inflammation, thrombosis and atherosclerosis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Disease Markers. - 22 : 3 (2006), p. 133-140. -
További szerzők:Magyar Mária Tünde (1970-) (neurológus) Bereczki Dániel (1960-) (neurológus) Valikovics Attila Nagy Emőke Barna Erika Pál András Balla György (1953-) (csecsemő és gyermekgyógyász, neonatológus) Csiba László (1952-) (neurológus, pszichiáter) Blaskó György (1947-) (belgyógyász, klinikai farmakológus)
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2.

001-es BibID:BIBFORM004806
Első szerző:Harangi Mariann (belgyógyász, endokrinológus)
Cím:Association between human paraoxonase 1 activity and intima-media thickness in subjects under 55 years of age with carotid artery disease / Mariann Harangi, Ildiko Seres, Maria T. Magyar, Istvan Csipo, Sandor Sipka, Attila Valikovics, Laszlo Csiba, Daniel Bereczki, Gyorgy Paragh
Dátum:2008
Megjegyzések:Human serum paraoxonase (PON1) protects lipoproteins against oxidation by hydrolyzing lipid peroxides in oxidized low-density lipoprotein (oxLDL); therefore, it may protect against atherosclerosis. PON1 activity and polymorphisms have been inconsistently associated with carotid artery disease. The goal of this study was to clarify the role of PON1 activity and phenotype on carotid artery disease and its correlation with some inflammatory and immune markers in subjects under 55 years with early-onset carotid atherosclerosis. Methods: Sixty patients with occlusive carotid artery disease and 30 healthy controls were enrolled. Intimamedia thickness (IMT) was measured by high-resolution ultrasound of both common carotid arteries. Anti-oxLDL antibody levels were determined by ELISA. Results: In the whole study population we found a negative correlation between PON1 activity and IMT (r = -0.27, p = 0.011), and between saltstimulated PON1 activity and IMT (r = -0.24, p = 0.02). Both PON1 activity and salt-stimulated PON1 activity negatively correlated with anti-oxLDL levels (r = -0.28, p = 0.008; r = -0.26, p = 0.01). PON1 activity was lower in patients compared to controls; however, the difference was not significant.PON1 phenotype distribution of patients and controls did not differ significantly. Conclusion: The importance of PON1 activity as a redictive risk factor for early-onset occlusive carotid artery disease should be assessed in future studies.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Paraoxonase
Intima-media thickness
egyetemen (Magyarországon) készült közlemény
Megjelenés:Cerebrovascular Diseases 25 : 1-2 (2008), p. 122-128. -
További szerzők:Seres Ildikó (1954-) (biokémikus) Magyar Mária Tünde (1970-) (neurológus) Csípő István (1953-) (vegyész) Sipka Sándor (1945-) (laboratóriumi szakorvos) Valikovics Attila Csiba László (1952-) (neurológus, pszichiáter) Bereczki Dániel (1960-) (neurológus) Paragh György (1953-) (belgyógyász)
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3.

001-es BibID:BIBFORM086752
Első szerző:Magyar Mária Tünde (neurológus)
Cím:White blood cell count subtypes in patients with early onset occlusive carotid artery disease / Magyar Mária Tünde, Talian T., Valikovics Attila, Csiba László, Bereczki Dániel
Dátum:2005
ISSN:1351-5101
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:European Journal of Neurology. - 12 : Suppl2 (2005), p. 54. -
További szerzők:Talián T. Valikovics Attila Csiba László (1952-) (neurológus, pszichiáter) Bereczki Dániel (1960-) (neurológus)
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DOI
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4.

001-es BibID:BIBFORM086000
Első szerző:Magyar Mária Tünde (neurológus)
Cím:Is CRP level stable in patients with early onset of occlusive carotid artery disease? / Magyar Mária Tünde, Valikovics Attila, Csiba László, Bereczki Dániel
Dátum:2005
ISSN:0022-510X
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Journal of the Neurological Sciences. - 238 : S1 (2005), p. S417. -
További szerzők:Valikovics Attila Csiba László (1952-) (neurológus, pszichiáter) Bereczki Dániel (1960-) (neurológus)
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DOI
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5.

001-es BibID:BIBFORM029321
Első szerző:Magyar Mária Tünde (neurológus)
Cím:Changes of cerebral hemodynamics in hypertensives during physical exercise / Magyar, M. T., Valikovics, A., Czuriga, I., Csiba, L.
Dátum:2005
ISSN:1051-2284
Megjegyzések:Previously, 30 untreated hypertensive patients were investigated by transcranial Doppler (TCD) monitoring during physical exercise, and changes of hemodynamic parameters were compared with those of age matched healthy subjects. After 3-year antihypertensive (AHT) treatment, these hypertensives were investigated again. The aim of this study was to compare the cerebral hemodynamic changes in the regularly treated and noncompliant (untreated) hypertensives during ergometer cycling. METHODS: Nineteen of 30 previously untreated hypertensive patients could be investigated again using the same method as before. Eleven were regularly treated (treated hypertensive [T-HT] group), and 8 did not take their AHT medications due to lack of compliance (noncompliant hypertensive [NC-HT] group). Blood pressure, heart rate, end-tidal CO2 (etCO2; Capnogard capnograph), and bilateral middle cerebral artery mean blood flow velocity (MV) were continuously monitored during ergometer cycling according to the World Health Organization protocol. Values of 2-minute loading were analyzed. RESULTS: Median loading time did not differ significantly between the T-HT and NC-HT groups. After 2 minutes of cycling in treated patients, the ratio of MV and etCO changes (DeltaMV/DeltaetCO2) showed similar values as before therapy (P = .38), whereas in noncompliant patients, a further worsening of the ratio of DeltaMV/DeltaetCO2 could be observed (P = .04). CONCLUSION: The decrease of arteriolar vasodilation (ie, the ratio of DeltaMV/DeltaetCO2) could be demonstrated in the NC-HT group after 3 years. TCD combined with ergometer cycling is a useful method for evaluation of cerebral hemodynamic changes after AHT therapy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Neuroimaging. - 15 : 1 (2005), p. 64-69. -
További szerzők:Valikovics Attila Czuriga István (1948-2018) (kardiológus) Csiba László (1952-) (neurológus, pszichiáter)
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6.

001-es BibID:BIBFORM029269
Első szerző:Magyar Mária Tünde (neurológus)
Cím:Transcranial Doppler monitoring in hypertensive patients during physical exercise / Magyar, M. T., Valikovics, A., Bereczki, D., Ficzere, A., Czuriga, I., Csiba, L.
Dátum:2001
ISSN:1015-9770
Megjegyzések:To evaluate the diagnostic value of a combined method, i.e. ergometer cycling with continuous bilateral transcranial Doppler monitoring (TCD) to detect cerebral hemodynamic abnormalities in recently diagnosed hypertensive patients. METHODS: 30 neurologically symptom-free, nontreated patients with essential hypertension and 30 age- and sex-matched controls were studied. Carotid ultrasound, resting ECG and blood parameters were investigated. Cycling ergometry was performed according to the WHO protocol. Blood pressure, heart rate, end-tidal CO2 (etCO2) and bilateral middle cerebral artery (MCA) blood flow velocity (MV) were monitored. RESULTS: At rest, MV in the MCA did not differ significantly between controls and hypertensive subjects. MV continuously increased in controls until the end of loading whereas a plateau was reached at 4 min in hypertensive subjects. During 6 min of cycling, the time course of absolute values of MV in the MCA and that of the changes in the ratio of mean velocity/end-tidal CO2 (DeltaMV/DeltaetCO2) differed significantly between hypertensive subjects and controls (p = 0.03 and p = 0.02, respectively). CONCLUSION: Ergometer cycling combined with TCD revealed altered vasoreactivity, therefore this may be a sensitive method for the detection of early hemodynamic impairment in nontreated hypertensive subjects.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Cerebrovascular diseases. - 12 : 3 (2001), p. 186-191. -
További szerzők:Valikovics Attila Bereczki Dániel (1960-) (neurológus) Ficzere Andrea (1967-) (neurológus) Czuriga István (1948-2018) (kardiológus) Csiba László (1952-) (neurológus, pszichiáter)
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7.

001-es BibID:BIBFORM017679
Első szerző:Magyar Mária Tünde (neurológus)
Cím:Serum cholesterols have a more important role than triglycerides in determining intima-media thickness of the common carotid artery in subjects younger than 55 years of age / Magyar M. T., Paragh G., Katona E., Valikovics A., Seres I., Csiba L., Bereczki D.
Dátum:2004
Megjegyzések:The role of serum cholesterol and triglycerides in carotid artery atherosclerosis is controversial. We measured carotid artery intima-media thickness (IMT), a marker of atherosclerosis in subjects younger than 55 years of age with a 6-fold range of serum cholesterol levels (3.93-25.03 mmol/L) and a 200-fold range of triglyceride levels (0.36-75.97 mmol/L). METHODS: Eighty-six patients with increased serum lipid values and 30 subjects with normal lipid values were included. Serum lipids were measured after an overnight fast. High-resolution sonographic investigations of the carotid arteries of all patients were videotaped. Intima-media thickness was measured offline at 1-mm increments in the distal 10-mm segments of both common carotid arteries by a reader blinded to patient characteristics. First, IMT was compared among groups defined by their cholesterol and triglyceride levels with the use of traditional cutoff values. Next, all subjects were pooled, and general regression analysis was performed to identify significant predictors of IMT with age, body mass index, lipid values, sex, diabetes, hypertension, and smoking status as independent variables. RESULTS: Intima-media thickness was larger in patient groups with high cholesterol levels (ie, the hypercholesterolemic and combined hyperlipidemic groups) than in the control, borderline, and isolated hypertriglyceridemic groups (P < .01). In the general multiple regression model, IMT correlated positively with total cholesterol level (beta = 0.343; P = .002) and age (beta = 0.3; P = .006) but not with triglyceride level. CONCLUSIONS: Both the group comparisons and the general regression analysis of the pooled data suggest that hypercholesterolemia has an important role in early onset IMT changes in the common carotid artery, whereas hypertriglyceridemia does not have an appreciable role.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Ultrasound Medicine. - 23 : 9 (2004), p. 1161-1169. -
További szerzők:Paragh György (1953-) (belgyógyász) Katona Evelin (1974-) (belgyógyász) Valikovics Attila Seres Ildikó (1954-) (biokémikus) Csiba László (1952-) (neurológus, pszichiáter) Bereczki Dániel (1960-) (neurológus)
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8.

001-es BibID:BIBFORM023036
Első szerző:Magyar Mária Tünde (neurológus)
Cím:Early-onset carotid atherosclerosis is associated with increased intima-media thickness and elevated serum levels of inflammatory markers / Magyar M. T., Szikszai Z., Balla J., Valikovics A., Kappelmayer J., Imre S., Balla G., Jeney V., Csiba L., Bereczki D.
Dátum:2003
ISSN:0039-2499
Megjegyzések:Background and Purpose-Several factors have been held responsible for the development of atherosclerosis. To avoid the masking effect of age, we evaluated correlates of carotid atherosclerosis in patients <55 years of age..Methods-Plasma lipids, oxidative resistance of low-density lipoprotein, homocysteine, inflammatory markers, plasma viscosity, and red cell deformability were measured in fasting blood samples of 100 subjects: 45 patients with >30% stenosis of the internal carotid artery, 20 patients with carotid occlusion, and 35 control subjects. Stenosis and intima-media thickness (IMT) of the carotid artery were evaluated by duplex ultrasound.Results-White blood cell (WBC) count, plasma fibrinogen, C-reactive protein (CRP), and lipoprotein(a) levels were significantly higher in patients than in control subjects, and patients had increased IMT (P<0.01 for all comparisons). There was a tendency for higher homocysteine levels in patients. Smokers had higher WBC, fibrinogen, and CRP levels. After the effect of smoking was controlled for, WBC count, natural logarithmic transform of homocysteine, and online-measured IMT remained significantly higher in patients than in control subjects. WBC, fibrinogen, and CRP levels were highest in the highest IMT quartile (P=0.012, P=0.007, and P=0.036, respectively).Conclusions-Inflammatory markers and homocysteine have a more important role than lipid factors in early-onset carotid atherosclerosis. We cannot recommend the measurement of low-density lipoprotein peroxidation as a routine screening test to identify high-risk patients for early-onset carotid atherosclerosis. The confounding effect of smoking on inflammatory markers should be considered in studies on atherosclerosis.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Stroke. - 34 : 1 (2003), p. 58-63. -
További szerzők:Szikszai Zita (1969-) (fizikus) Balla József (1959-) (belgyógyász, nephrológus) Valikovics Attila Kappelmayer János (1960-) (laboratóriumi szakorvos) Imre Sándor (1941-) (pathofiziológus) Balla György (1953-) (csecsemő és gyermekgyógyász, neonatológus) Jeney Viktória (1971-) (vegyész, kémia tanár) Csiba László (1952-) (neurológus, pszichiáter) Bereczki Dániel (1960-) (neurológus)
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9.

001-es BibID:BIBFORM002294
Első szerző:Magyar Mária Tünde (neurológus)
Cím:Elevated white blood cell count, CRP and fibrinogen levels are not associated with increased anti-endothelial and anti-ox-LDL antibody, MCP-1, and RANTES levels in early onset occlusive carotid artery disease / Magyar Mária Tünde, Bereczki Dániel, Csípő István, Gyimesi Edit, Csiba László, Valikovics Attila, Balla József, Sipka Sándor
Dátum:2007
Megjegyzések:Inflammatory processes have importance in atherosclerosis. We evaluated if subjects below 55 years of age with occlusive carotid artery disease have higher serum levels of antibodies against oxidized LDL and endothelial cells and the chemokines MCP-1 and RANTES than age matched subjects without atherosclerosis. Methods and results. Sixty patients with occlusive carotid artery disease (stenosis or occlusion) and 30 age-matched controls participated in the study. We measured the degree of carotid artery stenosis and intima-media thickness (IMT) by duplex ultrasound. White blood cell count (WBC), C-reactive protein (CRP), and fibrinogen levels were significantly higher in patients (means ± SD: 7.5 ± 1.8 vs. 6.1 ± 1.1 G/L, p < 0.001; 7.7 ± 20.7 vs. 2.5 ± 1.9 mg/L, p = 0.015; and 3.7 ± 0.9 vs. 3.1 ± 0.5 g/L, p < 0.001, respectively). Antibody levels against oxidized LDL and endothelial cells (21.1 ± 22.9 and 19.9 ± 15.3 EU/mL, p = 0.6; and 19 ± 15 vs. 20 ± 9 U/mL, p = 0.07) and RANTES and MCP-1 levels (72.4 ± 32.3 vs. 73.8 ± 27.3 ng/mL, p = 0.7; and 468 ± 1041 vs. 318 ± 131 pg/mL, p = 0.7) did not differ significantly between patients and controls and did not correlate with IMT. Conclusions. Higher levels of WBC, CRP, and fibrinogen suggest an ongoing inflammation in early-onset carotid atherosclerosis, but increased IMT is not associated by the elevation of serum levels of chemokines and antibodies evaluated in this study.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
atherosclerosis
inflammation
cytokines
Rantes
MCP-1
Megjelenés:Cytokine 37 : 1 (2007), p. 44-50. -
További szerzők:Bereczki Dániel (1960-) (neurológus) Csípő István (1953-) (vegyész) Gyimesi Edit (1957-) (klinikai biokémikus, vegyész) Csiba László (1952-) (neurológus, pszichiáter) Valikovics Attila Balla József (1959-) (belgyógyász, nephrológus) Sipka Sándor (1945-) (laboratóriumi szakorvos)
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10.

001-es BibID:BIBFORM049013
Első szerző:Valikovics Attila
Cím:Színkódolt transcranialis Doppler-szonográfia : modern noninvazív eljárás a cerebrovascularis megbetegedések diagnosztikájában / Valikovics Attila, Magyar Tünde, Fülesdi Béla, Wolfgang Rautenberg
Dátum:1998
Tárgyszavak:Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban
Megjelenés:Agyérbetegségek. - 4 : 2 (1998), p. 8-10. -
További szerzők:Magyar Mária Tünde (1970-) (neurológus) Fülesdi Béla (1961-) (aneszteziológus) Rautenberg, Wolfgang
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11.

001-es BibID:BIBFORM001510
Első szerző:Zsuga Judit (neurológus, pszichoterapeuta, egészségügyi szakmanager)
Cím:Dimethylarginines at the crossroad of insulin resistance and atherosclerosis / Judit Zsuga, János Török, Mária T. Magyar, Attila Valikovics, Rudolf Gesztelyi, Ágota Lenkey, László Csiba, Sándor Kéki, Miklós Zsuga, Dániel Bereczki
Dátum:2007
Megjegyzések:We tested if asymmetric dimethylarginine (ADMA)contributes to the simultaneous evolution of atherosclerosis and insulin resistance. We investigated the significant predictors of insulin resistance in the context of atherosclerosis, focusing on the role ADMA, symmetric dimethylarginine (SDMA), and l-arginine play in a cohort of young atherosclerotic patients and their age-matched controls. In a case-control study, 60 patients younger than 55 years having at least 30% stenosis of the internal carotid artery and 30 age- and sex-matched controls were recruited at a community-based neurosonologic laboratory. We found a strong positive association between the homeostasis model assessment of beta-cell function and insulin resistance and the ADMA/SDMA ratio that remained statistically significant even after adjusting for all significant and a priori identified determinants (beta = 6.76; 95% confidence interval [CI], 2.13-11.39; P = .005). Interestingly, this relationship was even more pronounced in the atherosclerotic stratum (beta = 8.29; 95% CI, 1.43-15.15; P = .019), whereas, on multiple linear regression, lack of association was seen in subjects free of carotid atherosclerosis (beta = 1.39; 95% CI, -5.46 to 8.26; P = .671). We conclude that ADMA/SDMA ratio is a significant determinant of insulin resistance and may be a better parameter to monitor than ADMA alone. By accounting for the competition at the y+ transporters, ADMA/SDMA ratio could be an indicator of intracellular ADMA level.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Metabolism: Clinical and Experimental 56 : 3 (2007), p. 394-399. -
További szerzők:Török János Magyar Mária Tünde (1970-) (neurológus) Valikovics Attila Gesztelyi Rudolf (1969-) (kísérletes farmakológus) Lenkey Ágota (1944-) (biológus) Csiba László (1952-) (neurológus, pszichiáter) Kéki Sándor (1964-) (polimer kémikus) Zsuga Miklós (1944-) (polimer kémikus) Bereczki Dániel (1960-) (neurológus)
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12.

001-es BibID:BIBFORM001509
Első szerző:Zsuga Judit (neurológus, pszichoterapeuta, egészségügyi szakmanager)
Cím:Serum asymmetric dimethylarginine negatively correlates with intima-media thickness in early-onset atherosclerosis / Judit Zsuga, Janos Török, Mária Tünde Magyar, Attila Valikovics, Rudolf Gesztelyi, Sándor Kéki, Laszló Csiba, Miklos Zsuga, Dániel Bereczki
Dátum:2007
Megjegyzések:Asymmetric dimethylarginine (ADMA) assumes a significant role in atherosclerosis by inhibiting the endothelial nitric oxide synthase (eNOS). Moreover, ADMA inhibits the inducible NOS (iNOS), the isoform that triggers atherosclerosis via peroxynitrite formation. Therefore, we investigated whether ADMA is a risk or protective factor in the atherosclerotic process. Intima-media thickness (IMT) of the common carotid artery, a surrogate for vascular diseases,was chosen as the outcome variable of interest. Methods: Sixty patients younger than 55 years having at least 30% stenosis of the internal carotid artery and 30 age- and gendermatched controls were recruited at a community-based neurosonological laboratory. We investigated relatively young patients to circumvent the confounding effect age has in the development of atherosclerosis. Results: The IMT showed a negative correlation with ADMA upon analysis of the pooled data (Spearman correlation coefficient -0.300, p = 0.0041) and the atherosclerotic stratum (Spearman correlation coefficient -0.323, p = 0.012). A multiple linear regression model containing all determinant factors of IMT previously identified by simple regression was used to further quantify the relationship between IMT and ADMA. Thenegative association between IMT and ADMA remained statistically significant ( beta: -0.510, CI: -0.894, -0.127; p = 0.010), furthermore it was even stronger in the atherosclerotic stratum( beta : -0.67, CI: -1.16, -0.18; p = 0.008). Conclusions: A minimal increase in ADMA concentration may be protective by inhibiting iNOS but not eNOS in states where iNOS is induced, e.g. inflammation accompanying atherosclerosis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
atherosclerosis
inflammation
carotid arteries
vascular risk factors
nitric oxide synthase
Megjelenés:Cerebrovascular Diseases 23 : 5-6 (2007), p. 388-394. -
További szerzők:Török János Magyar Mária Tünde (1970-) (neurológus) Valikovics Attila Gesztelyi Rudolf (1969-) (kísérletes farmakológus) Kéki Sándor (1964-) (polimer kémikus) Csiba László (1952-) (neurológus, pszichiáter) Zsuga Miklós (1944-) (polimer kémikus) Bereczki Dániel (1960-) (neurológus)
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