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001-es BibID:BIBFORM068277
Első szerző:Csongrádi Éva (szakorvos)
Cím:Adipokines as atherothrombotic risk factors in obese subjects : associations with haemostatic markers and common carotid wall thickness / É. Csongrádi, M. Káplár, B. Nagy Jr., C. A. Koch, A. Juhász, L. Bajnok, Zs. Varga, I. Seres, Zs. Karányi, M. T. Magyar, L. Oláh, A. Facskó, J. Kappelmayer, Gy. Paragh
Dátum:2017
ISSN:0939-4753
Megjegyzések:Background and aims: Some crucial associations between obesity-related altered adipokinelevels and the main factors of atherosclerotic, atherothrombotic processes are not fully known.We analysed the relationships of classic adipokines, namely leptin, resistin, adiponectin, tumour necrosisfactor-alpha (TNF-a), interleukin 6 (IL-6) with the markers of platelet activation, including meanplatelet volume (MPV), platelet surface/soluble P-selectin, platelet-derived microparticles (PMPs), theparameters of coagulation abnormalities and common carotid intima-media thickness (IMT) in obesepatients with or without atheroscleroticcomorbidities in comparison to age- and sex-matched controls.Methods and results: We enrolled 154 obese individuals, including 98 suffering from atheroscleroticconcomitant conditions, 56 free of atherosclerotic comorbidities and 62 healthy controls. Plasma levelsof leptin, resistin, adiponectin, TNF-a, IL-6, soluble P-selectin, and plasminogen activator inhibitor-1 antigen(PAI-1 ag) were analysed by ELISA. Platelet surface P-selectin and PMPs were measured by flowcytometry. IMT was detected by ultrasonography. Adipokines were closely associated withmarkers ofplatelet hyperactivity, hypercoagulability, hypofibrinolysis and IMT. Significant independent associationswere found between leptin and platelet count (p < 0.0001), MPV (p Z 0.019), PMPs(p < 0.0001), fibrinogen (pZ0.001), factor VIII (FVIII) activity (pZ0.035); adiponectin and PAI-1 ag(pZ0.035); resistin and soluble P-selectin (pZ0.002); TNF-a and PAI-1 ag (p < 0.0001); and IL-6and fibrinogen (pZ 0.011). Finally, leptin (p Z 0.0005), adiponectin (pZ 0.019), IL-6 (p Z 0.001),MPV(pZ0.0003), PMP (pZ0.008), and FVIII activity (pZ0.043)were independent predictors of IMT.Conclusion: Overall,we suggest that inobese subjects altered adipokinelevels playa key role incommoncarotid atherosclerosis both directly and through haemostatic parameters.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Obesity
Adipokines
Atherosclerosis
Haemostasis
Common carotid intima-media thickness
Megjelenés:Nutrition Metabolism And Cardiovascular Diseases 27 : 6 (2017), p. 571-580. -
További szerzők:Káplár Miklós (1965-) (belgyógyász, diabetológus) Nagy Béla Jr. (1980-) (labordiagnosztikai szakorvos) Koch, Christian A. Juhász Attila (1970-) (szakorvos, klinikai mikrobiológus) Bajnok László (1961-) (belgyógyász) Varga Zsuzsa (1951-) (biokémikus, nephrológus) Seres Ildikó (1954-) (biokémikus) Karányi Zsolt (1961-) (biostatisztikus, bioinformatikus) Magyar Mária Tünde (1970-) (neurológus) Oláh László (1967-) (neurológus) Facskó Andrea (1953-) (szemész) Kappelmayer János (1960-) (laboratóriumi szakorvos) Paragh György (1953-) (belgyógyász)
Pályázati támogatás:K75199
OTKA
TÁMOP 4.2.1/B-091/1/KONV-2010-0007
TÁMOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM004806
Első szerző:Harangi Mariann (belgyógyász, endokrinológus)
Cím:Association between human paraoxonase 1 activity and intima-media thickness in subjects under 55 years of age with carotid artery disease / Mariann Harangi, Ildiko Seres, Maria T. Magyar, Istvan Csipo, Sandor Sipka, Attila Valikovics, Laszlo Csiba, Daniel Bereczki, Gyorgy Paragh
Dátum:2008
Megjegyzések:Human serum paraoxonase (PON1) protects lipoproteins against oxidation by hydrolyzing lipid peroxides in oxidized low-density lipoprotein (oxLDL); therefore, it may protect against atherosclerosis. PON1 activity and polymorphisms have been inconsistently associated with carotid artery disease. The goal of this study was to clarify the role of PON1 activity and phenotype on carotid artery disease and its correlation with some inflammatory and immune markers in subjects under 55 years with early-onset carotid atherosclerosis. Methods: Sixty patients with occlusive carotid artery disease and 30 healthy controls were enrolled. Intimamedia thickness (IMT) was measured by high-resolution ultrasound of both common carotid arteries. Anti-oxLDL antibody levels were determined by ELISA. Results: In the whole study population we found a negative correlation between PON1 activity and IMT (r = -0.27, p = 0.011), and between saltstimulated PON1 activity and IMT (r = -0.24, p = 0.02). Both PON1 activity and salt-stimulated PON1 activity negatively correlated with anti-oxLDL levels (r = -0.28, p = 0.008; r = -0.26, p = 0.01). PON1 activity was lower in patients compared to controls; however, the difference was not significant.PON1 phenotype distribution of patients and controls did not differ significantly. Conclusion: The importance of PON1 activity as a redictive risk factor for early-onset occlusive carotid artery disease should be assessed in future studies.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Paraoxonase
Intima-media thickness
egyetemen (Magyarországon) készült közlemény
Megjelenés:Cerebrovascular Diseases 25 : 1-2 (2008), p. 122-128. -
További szerzők:Seres Ildikó (1954-) (biokémikus) Magyar Mária Tünde (1970-) (neurológus) Csípő István (1953-) (vegyész) Sipka Sándor (1945-) (laboratóriumi szakorvos) Valikovics Attila Csiba László (1952-) (neurológus, pszichiáter) Bereczki Dániel (1960-) (neurológus) Paragh György (1953-) (belgyógyász)
Internet cím:DOI
elektronikus változat
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3.

001-es BibID:BIBFORM017679
Első szerző:Magyar Mária Tünde (neurológus)
Cím:Serum cholesterols have a more important role than triglycerides in determining intima-media thickness of the common carotid artery in subjects younger than 55 years of age / Magyar M. T., Paragh G., Katona E., Valikovics A., Seres I., Csiba L., Bereczki D.
Dátum:2004
Megjegyzések:The role of serum cholesterol and triglycerides in carotid artery atherosclerosis is controversial. We measured carotid artery intima-media thickness (IMT), a marker of atherosclerosis in subjects younger than 55 years of age with a 6-fold range of serum cholesterol levels (3.93-25.03 mmol/L) and a 200-fold range of triglyceride levels (0.36-75.97 mmol/L). METHODS: Eighty-six patients with increased serum lipid values and 30 subjects with normal lipid values were included. Serum lipids were measured after an overnight fast. High-resolution sonographic investigations of the carotid arteries of all patients were videotaped. Intima-media thickness was measured offline at 1-mm increments in the distal 10-mm segments of both common carotid arteries by a reader blinded to patient characteristics. First, IMT was compared among groups defined by their cholesterol and triglyceride levels with the use of traditional cutoff values. Next, all subjects were pooled, and general regression analysis was performed to identify significant predictors of IMT with age, body mass index, lipid values, sex, diabetes, hypertension, and smoking status as independent variables. RESULTS: Intima-media thickness was larger in patient groups with high cholesterol levels (ie, the hypercholesterolemic and combined hyperlipidemic groups) than in the control, borderline, and isolated hypertriglyceridemic groups (P < .01). In the general multiple regression model, IMT correlated positively with total cholesterol level (beta = 0.343; P = .002) and age (beta = 0.3; P = .006) but not with triglyceride level. CONCLUSIONS: Both the group comparisons and the general regression analysis of the pooled data suggest that hypercholesterolemia has an important role in early onset IMT changes in the common carotid artery, whereas hypertriglyceridemia does not have an appreciable role.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Ultrasound Medicine. - 23 : 9 (2004), p. 1161-1169. -
További szerzők:Paragh György (1953-) (belgyógyász) Katona Evelin (1974-) (belgyógyász) Valikovics Attila Seres Ildikó (1954-) (biokémikus) Csiba László (1952-) (neurológus, pszichiáter) Bereczki Dániel (1960-) (neurológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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