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001-es BibID:	BIBFORM020965
035-os BibID:	PMID:16788247
Első szerző:	Balla József (belgyógyász, nephrológus)
Cím:	Serum levels of platelet released CD40 ligand are increased in early onset occlusive carotid artery disease / József Balla, Mária Tünde Magyar, Dániel Bereczki, Attila Valikovics, Emőke Nagy, Erika Barna, András Pál, György Balla, László Csiba, György Blaskó
Dátum:	2006
Megjegyzések:	Soluble CD40 ligand (sCD40L) has been suggested as a key mediator between inflammation and atherosclerosis, and the CD40-CD40L interaction has a role in atherosclerotic lesion progression. We evaluated if platelet released serum sCD40L and sCD40 levels differ between patients with early onset occlusive carotid artery disease and age-matched controls. METHODS: sCD40L and sCD40 levels were measured in serum samples of 60 patients with occlusive carotid artery disease and 30 age-matched controls using ELISA. Degree of stenosis of the internal carotid artery (ICA), and intima-media thickness (IMT) in the common carotid artery were measured by high resolution ultrasound. Values are given as mean +/- SD. RESULTS: Mean age was 50.9 +/- 3.5 and 50.1 +/- 3.5 years in the patient and control groups. IMT was significantly thicker in patients than in controls (0.89 +/- 0.14 vs. 0.78 +/-0.12 mm, p=0.0003). Serum levels of sCD40L were significantly higher (6.9 +/- 5 vs. 4.5 +/- 3.0 ng/mL, p=0.038) in patients, whereas sCD40 did not differ significantly between patients and controls (85 +/- 56.9 vs. 79.3 +/- 18.7 pg/mL, p=0.34). IMT did not correlate with sCD40L or sCD40 levels (R=-0.03, p=0.77; and R=0.109, p=0.308, respectively). CONCLUSIONS: sCD40L but not sCD40 levels are significantly higher in patients with occlusive carotid artery disease. Platelet derived sCD40L may be a key mediator among inflammation, thrombosis and atherosclerosis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Disease Markers. - 22 : 3 (2006), p. 133-140. -
További szerzők:	Magyar Mária Tünde (1970-) (neurológus) Bereczki Dániel (1960-) (neurológus) Valikovics Attila Nagy Emőke Barna Erika Pál András Balla György (1953-) (csecsemő és gyermekgyógyász, neonatológus) Csiba László (1952-) (neurológus, pszichiáter) Blaskó György (1947-) (belgyógyász, klinikai farmakológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM040766
Első szerző:	Bereczki Dániel (neurológus)
Cím:	Should soluble CD40 ligand be measured from serum or plasma samples? / Dániel Bereczki, Emőke Nagy, András Pál, Mária T. Magyar, József Balla
Dátum:	2003
ISSN:	1079-5642
Tárgyszavak:	Orvostudományok Klinikai orvostudományok szerkesztői levél
Megjelenés:	Arteriosclerosis Thrombosis And Vascular Biology 23 : 6 (2003), p. 1129-1130. -
További szerzők:	Nagy Emőke (neonatológus, gyermekgyógyász) Pál András Magyar Mária Tünde (1970-) (neurológus) Balla József (1959-) (belgyógyász, nephrológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM023036
Első szerző:	Magyar Mária Tünde (neurológus)
Cím:	Early-onset carotid atherosclerosis is associated with increased intima-media thickness and elevated serum levels of inflammatory markers / Magyar M. T., Szikszai Z., Balla J., Valikovics A., Kappelmayer J., Imre S., Balla G., Jeney V., Csiba L., Bereczki D.
Dátum:	2003
ISSN:	0039-2499
Megjegyzések:	Background and Purpose-Several factors have been held responsible for the development of atherosclerosis. To avoid the masking effect of age, we evaluated correlates of carotid atherosclerosis in patients <55 years of age..Methods-Plasma lipids, oxidative resistance of low-density lipoprotein, homocysteine, inflammatory markers, plasma viscosity, and red cell deformability were measured in fasting blood samples of 100 subjects: 45 patients with >30% stenosis of the internal carotid artery, 20 patients with carotid occlusion, and 35 control subjects. Stenosis and intima-media thickness (IMT) of the carotid artery were evaluated by duplex ultrasound.Results-White blood cell (WBC) count, plasma fibrinogen, C-reactive protein (CRP), and lipoprotein(a) levels were significantly higher in patients than in control subjects, and patients had increased IMT (P<0.01 for all comparisons). There was a tendency for higher homocysteine levels in patients. Smokers had higher WBC, fibrinogen, and CRP levels. After the effect of smoking was controlled for, WBC count, natural logarithmic transform of homocysteine, and online-measured IMT remained significantly higher in patients than in control subjects. WBC, fibrinogen, and CRP levels were highest in the highest IMT quartile (P=0.012, P=0.007, and P=0.036, respectively).Conclusions-Inflammatory markers and homocysteine have a more important role than lipid factors in early-onset carotid atherosclerosis. We cannot recommend the measurement of low-density lipoprotein peroxidation as a routine screening test to identify high-risk patients for early-onset carotid atherosclerosis. The confounding effect of smoking on inflammatory markers should be considered in studies on atherosclerosis.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Stroke. - 34 : 1 (2003), p. 58-63. -
További szerzők:	Szikszai Zita (1969-) (fizikus) Balla József (1959-) (belgyógyász, nephrológus) Valikovics Attila Kappelmayer János (1960-) (laboratóriumi szakorvos) Imre Sándor (1941-) (pathofiziológus) Balla György (1953-) (csecsemő és gyermekgyógyász, neonatológus) Jeney Viktória (1971-) (vegyész, kémia tanár) Csiba László (1952-) (neurológus, pszichiáter) Bereczki Dániel (1960-) (neurológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM002294
Első szerző:	Magyar Mária Tünde (neurológus)
Cím:	Elevated white blood cell count, CRP and fibrinogen levels are not associated with increased anti-endothelial and anti-ox-LDL antibody, MCP-1, and RANTES levels in early onset occlusive carotid artery disease / Magyar Mária Tünde, Bereczki Dániel, Csípő István, Gyimesi Edit, Csiba László, Valikovics Attila, Balla József, Sipka Sándor
Dátum:	2007
Megjegyzések:	Inflammatory processes have importance in atherosclerosis. We evaluated if subjects below 55 years of age with occlusive carotid artery disease have higher serum levels of antibodies against oxidized LDL and endothelial cells and the chemokines MCP-1 and RANTES than age matched subjects without atherosclerosis. Methods and results. Sixty patients with occlusive carotid artery disease (stenosis or occlusion) and 30 age-matched controls participated in the study. We measured the degree of carotid artery stenosis and intima-media thickness (IMT) by duplex ultrasound. White blood cell count (WBC), C-reactive protein (CRP), and fibrinogen levels were significantly higher in patients (means ± SD: 7.5 ± 1.8 vs. 6.1 ± 1.1 G/L, p < 0.001; 7.7 ± 20.7 vs. 2.5 ± 1.9 mg/L, p = 0.015; and 3.7 ± 0.9 vs. 3.1 ± 0.5 g/L, p < 0.001, respectively). Antibody levels against oxidized LDL and endothelial cells (21.1 ± 22.9 and 19.9 ± 15.3 EU/mL, p = 0.6; and 19 ± 15 vs. 20 ± 9 U/mL, p = 0.07) and RANTES and MCP-1 levels (72.4 ± 32.3 vs. 73.8 ± 27.3 ng/mL, p = 0.7; and 468 ± 1041 vs. 318 ± 131 pg/mL, p = 0.7) did not differ significantly between patients and controls and did not correlate with IMT. Conclusions. Higher levels of WBC, CRP, and fibrinogen suggest an ongoing inflammation in early-onset carotid atherosclerosis, but increased IMT is not associated by the elevation of serum levels of chemokines and antibodies evaluated in this study.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban atherosclerosis inflammation cytokines Rantes MCP-1
Megjelenés:	Cytokine 37 : 1 (2007), p. 44-50. -
További szerzők:	Bereczki Dániel (1960-) (neurológus) Csípő István (1953-) (vegyész) Gyimesi Edit (1957-) (klinikai biokémikus, vegyész) Csiba László (1952-) (neurológus, pszichiáter) Valikovics Attila Balla József (1959-) (belgyógyász, nephrológus) Sipka Sándor (1945-) (laboratóriumi szakorvos)
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