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1.

001-es BibID:BIBFORM040492
Első szerző:Ferraguti, Francesco
Cím:Metabotropic Glutamate Receptor 8-Expressing Nerve Terminals Target Subsets of GABAergic Neurons in the Hippocampus / Francesco Ferraguti, Thomas Klausberger, Philip Cobden, Agnes Baude, J. David B. Roberts, Peter Szucs, Ayae Kinoshita, Ryuichi Shigemoto, Peter Somogyi, Yannis Dalezios
Dátum:2005
ISSN:0270-6474
Megjegyzések:Presynaptic metabotropic glutamate receptors (mGluRs) show a highly selective expression and subcellular location in nerve terminals modulating neurotransmitter release. We have demonstrated that alternatively spliced variants of mGluR8, mGluR8a and mGluR8b, have an overlapping distribution in the hippocampus, and besides perforant path terminals, they are expressed in the presynaptic active zone of boutons making synapses selectively with several types of GABAergic interneurons, primarily in the stratum oriens. Boutons labeled for mGluR8 formed either type I or type II synapses, and the latter were GABAergic. Some mGluR8-positive boutons also expressed mGluR7 or vasoactive intestinal polypeptide. Interneurons strongly immunopositive for the muscarinic M2 or the mGlu1 receptors were the primary targets of mGluR8-containing terminals in the stratum oriens, but only neurochemically distinct subsets were innervated by mGluR8-enriched terminals. The majority of M2-positive neurons were mGluR8 innervated, but a minority, which expresses somatostatin, was not. Rare neurons coexpressing calretinin and M2 were consistently targeted by mGluR8-positive boutons. In vivo recording and labeling of an mGluR8-decorated and strongly M2-positive interneuron revealed a trilaminar cell with complex spike bursts during theta oscillations and strong discharge during sharp wave/ripple events. The trilaminar cell had a large projection from the CA1 area to the subiculum and a preferential innervation of interneurons in the CA1 area in addition to pyramidal cell somata and dendrites. The postsynaptic interneuron type-specific expression of the high-efficacy presynaptic mGluR8 in both putative glutamatergic and in identified GABAergic terminals predicts a role in adjusting the activity of interneurons depending on the level of network activity.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Neuroscience. - 25 : 45 (2005), p. 10520-10536. -
További szerzők:Klausberger, Thomas Cobden, Philip Baude, Agnes Roberts, J. David B. Szűcs Péter (1974-) (kutatóorvos) Kinoshita, Ayae Shigemoto, Ryuichi Somogyi Péter Dalezios, Yannis
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2.

001-es BibID:BIBFORM112029
035-os BibID:(WoS)000994001800006 (Scopus)85159545543
Első szerző:Luz, Liliana L.
Cím:Contralateral Afferent Input to Lumbar Lamina I Neurons as a Neural Substrate for Mirror-Image Pain / Liliana L. Luz, Susana Lima, Elisabete C. Fernandes, Eva Kokai, Lidia Gomori, Peter Szucs, Boris V. Safronov
Dátum:2023
ISSN:0270-6474 1529-2401
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal Of Neuroscience. - 43 : 18 (2023), p. 3245-3258. -
További szerzők:Lima, Susana Fernandes, Elisabete C. Kókai Éva (1989-) (molekuláris biológus) Gömöri Lídia (1999-) Szűcs Péter (1974-) (kutatóorvos) Safronov, Boris V.
Pályázati támogatás:KTIA_NAP_13-2-2014-0005
Egyéb
2017-1.2.1-NKP-2017-00002
Egyéb
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3.

001-es BibID:BIBFORM040315
035-os BibID:PMID:20147564
Első szerző:Pinto, Vitor
Cím:Multisegmental A[delta]- and C-fiber input to neurons in lamina I and the lateral spinal nucleus / Vitor Pinto, Peter Szucs, Deolinda Lima, Boris V. Safronov
Dátum:2010
ISSN:0270-6474
Megjegyzések:Spinal lamina I and the lateral spinal nucleus (LSN) receive and integrate nociceptive primary afferent inputs to project through diverse ascending pathways. The pattern of the afferent supply of individual lamina I and LSN neurons through different segmental dorsal roots is poorly understood. Therefore, we recorded responses of lamina I and LSN neurons in spinal segments L4 and L3 to stimulation of six ipsilateral dorsal roots (L1-L6). The neurons were viewed through the overlying white matter in the isolated spinal cord preparation using the oblique infrared LED illumination technique. Orientation of myelinated fibers in the white matter was used as a criterion to distinguish between the LSN and lamina I. Both types of neurons received mixed (monosynaptic and polysynaptic) excitatory Adelta- and C-fiber input from up to six dorsal roots, with only less than one-third of it arising from the corresponding segmental root. The largest mixed input arose from the dorsal root of the neighboring caudal segment. Lamina I and LSN neurons could fire spikes upon the stimulation of up to six different dorsal roots. We also found that individual lamina I neurons can receive converging monosynaptic Adelta- and/or C-fiber inputs from up to six segmental roots. This study shows that lamina I and LSN neurons function as intersegmental integrators of primary afferent inputs. We suggest that broad monosynaptic convergence of Adelta- and C-afferents onto a lamina I neuron is important for the somatosensory processing.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Journal of Neuroscience. - 30 : 6 (2010), p. 2384-2395. -
További szerzők:Szűcs Péter (1974-) (kutatóorvos) Lima, Deolinda Safronov, Boris V.
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM040318
035-os BibID:PMID:19014968
Első szerző:Szűcs Péter (kutatóorvos)
Cím:Advanced technique of infrared LED imaging of unstained cells and intracellular structures in isolated spinal cord, brainstem, ganglia and cerebellum / Péter Szűcs, Vitor Pinto, Boris V. Safronov
Dátum:2009
ISSN:0165-0270
Megjegyzések:Light-emitting diodes (LEDs) have recently been used for the imaging of unstained living cells in the whole brain and spinal cord preparations, in which one cut was done to remove the overlying white matter. Here we show that in many cases the neurones can be visualized through the white matter in an intact nervous tissue (rats P0-P36 and mice P0-P2). We used an upright microscope with a water immersion objective and a powerful infrared LED (emission peak, 850 nm; maximum radiant intensity, 270 mW/sr) as a source of oblique illumination. In the isolated spinal cord, we were able to visualize lamina I and II neurones as well as motoneurones. In the brainstem, the neurones from the superficial nuclei were successfully viewed. In the sensory ganglion, we obtained images of unstained cells as well as intracellular structures, like endoplasmic reticulum, nucleus and nucleolus. In isolated cerebellum, parallel fibers, Purkinje and granule cells were viewed. Whole-cell recordings were done to fill spinal lamina I neurones, motoneurones and brainstem neurones with biocytin for detailed 2D-3D reconstruction of their dendritic and axonal arbores. Our imaging technique also allowed labelling individual intact neurones by injecting biocytin through the extracellular cell-attached pipette. This imaging technique opens broad possibilities for functional studies of neurones with completely preserved anatomical structures and synaptic inputs. We also show that the application of oblique infrared LED illumination allows a construction of a simple digital videomicroscope for the high-quality living cell imaging in intact nervous tissue.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Journal of Neuroscience Methods. - 177 : 2 (2009), p. 369-380. -
További szerzők:Pinto, Vitor Safronov, Boris V.
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Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM029092
Első szerző:Szűcs Péter (kutatóorvos)
Cím:Neurons with distinctive firing patterns, morphology and distribution in laminae V-VII of the neonatal rat lumbar spinal cord / Szűcs P., Odeh F., Szokol K., Antal M.
Dátum:2003
Megjegyzések:It is generally accepted that neurons in the ventral spinal grey matter, a substantial proportion of which can be regarded as constituents of the spinal motor apparatus, receive and integrate synaptic inputs arising from various peripheral, spinal and supraspinal sources. Thus, a profound knowledge concerning the integrative properties of interneurons in the spinal ventral grey matter appears to be essential for a fair understanding of operational principles of spinal motor neural assemblies. Using the whole cell patch clamp configuration in a correlative physiological and morphological experimental approach, here we demonstrate that the intrinsic membrane properties of neurons vary widely in laminae V-VII of the ventral grey matter of the neonatal rat lumbar spinal cord. Based on their firing patterns in response to depolarizing current steps, we have classified the recorded neurons into four categories: 'phasic', 'repetitive', 'single' and 'slow'. Neurons with firing properties characteristic of the 'phasic', 'repetitive' and 'single' cells have previously been reported also in the superficial and deep spinal dorsal horn, but this is the first account in the literature in which 'slow' neurons have been recovered and described in the spinal cord. The physiological heterogeneity in conjunction with the morphological correlation and distribution of neurons argues that different components of motor neural assemblies in the spinal ventral grey matter possess different signal processing characteristics.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:European Journal of Neuroscience. - 17 : 3 (2003), p. 537-544. -
További szerzők:Odeh, Francis Szokol Karolina Antal Miklós (1951-) (orvos, anatómus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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