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001-es BibID:	BIBFORM040326
035-os BibID:	PMID:14523064
Első szerző:	Melnick, Igor V.
Cím:	Ionic basis of tonic firing in spinal substantia gelatinosa neurons of rat / Igor V. Melnick, Sónia F. A. Santos, Karolina Szokol, Péter Szűcs, Boris V. Safronov
Dátum:	2004
ISSN:	0022-3077
Megjegyzések:	Ionic conductances underlying excitability in tonically firing neurons (TFNs) from substantia gelatinosa (SG) were studied by the patch-clamp method in rat spinal cord slices. Ca(2+)-dependent K(+) (K(CA)) conductance sensitive to apamin was found to prolong the interspike intervals and stabilize firing evoked by a sustained membrane depolarization. Suppression of Ca(2+) and K(CA) currents, however, did not abolish the basic pattern of tonic firing, indicating that it was generated by voltage-gated Na(+) and K(+) currents. Na(+) and K(+) channels were further analyzed in somatic nucleated patches. Na(+) channels exhibited fast activation and inactivation kinetics and followed two-exponential time course of recovery from inactivation. The major K(+) current was carried through tetraethylammonium (TEA)-sensitive rapidly activating delayed-rectifier (K(DR)) channels with a slow inactivation. The TEA-insensitive transient A-type K(+) (K(A)) current was very small in patches and was strongly inactivated at resting potential. Block of K(DR) rather than K(A) conductance by 1 mM TEA lowered the frequency and stability of firing. Intracellular staining with biocytin revealed at least three morphological groups of TFNs. Finally, on the basis of present data, we created a model of TFN and showed that Na(+) and K(DR) currents are sufficient to generate a basic pattern of tonic firing. It is concluded that the balanced contribution of all ionic conductances described here is important for generation and modulation of tonic firing in SG neurons.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban külföldön készült közlemény
Megjelenés:	Journal of Neurophysiology. - 91 : 2 (2004), p. 646-655. -
További szerzők:	Santos, Sónia F. A. Szokol Karolina Szűcs Péter (1974-) (kutatóorvos) Safronov, Boris V.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM040317
Első szerző:	Santos, Sónia F. A.
Cím:	Transmission efficacy and plasticity in glutamatergic synapses formed by excitatory interneurons of the substantia gelatinosa in the rat spinal cord / Sónia F. A. Santos, Liliana L. Luz, Peter Szucs, Deolinda Lima, Victor A. Derkach, Boris V. Safronov
Dátum:	2009
ISSN:	1932-6203
Megjegyzések:	The article presents a study which examines the mechanism involved in the functional organization and properties of excitatory synapses formed by Substantia gelatinosa (SG) excitatory interneurons (EINs). It is said that most unmyelinated primary afferents conclude and the central nociceptive processing begins in SG, a spinal cord region. It is said that most of the SG neuron population is formed by glutamatergic EINs. In this study, non-invasive recordings were done from 183 pairs of monosynaptically connected neurons and evoked EPSCs/EPSPs were recorded through perforatedpatch from a postsynaptic neuron (laminae I-III). The results suggest that multiple synapses formed by an SG EIN on a postsynaptic neuron promotes synaptic excitation and results in diverse forms of plasticity.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban külföldön készült közlemény
Megjelenés:	Plos One. - 4 : 11 (2009), p. e8047. -
További szerzők:	Luz, Liliana L. Szűcs Péter (1974-) (kutatóorvos) Lima, Deolinda Derkach, Victor A. Safronov, Boris V.
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: