CCL

Összesen 7 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM029087
Első szerző:Antal Miklós (orvos, anatómus)
Cím:Development, neurochemical properties and axonal projections of a population of last-order premotor interneurons in the white matter of the chick lumbosacral spinal cord / Antal M., Puskár Z., Birinyi A., Storm-Mathisen J.
Dátum:2000
ISSN:1552-5007
Megjegyzések:There is general agreement that last-order premotor interneurons-a set of neurons that integrate activities generated by the spinal motor apparatus, sensory information and volleys arising from higher motor centres, and transmit the integrated signals to motoneurons through monosynaptic contacts-play crucial roles in the initiation and maintenance of spinal motor activities. Here, we demonstrate the development, neurochemical properties, and axonal projections of a unique group of last-order premotor interneurons within the ventrolateral aspect of the lateral funiculus of the chick lumbosacral spinal cord. Neurons expressing immunoreactivity for neuron-specific enolase were first detected in the ventrolateral white matter at embryonic day 9 (E9). The numbers of immunoreactive neurons were significantly increased at E10-E12, while most of them were gradually concentrated in small segmentally arranged nuclei (referred to as major nuclei of Hofmann) protruding from the white matter in a necklace like fashion dorsal to the ventral roots. The major nuclei of Hofmann became more prominent at E12-E16, but substantial numbers of cells were still located within the ventrolateral white matter (referred to as minor nucleus of Hofmann). The distribution of immunoreactive neurons achieved by E16 was maintained during later developmental stages and was also characteristic of adult animals. After injection of Phaseolus vulgaris-leucoagglutinin unilaterally into the minor nucleus of Hofmann, labeled fibres were detected in the ventrolateral white matter ipsilateral to the injection site. Ascending and descending fibres were revealed throughout the entire rostro-caudal length of the lumbosacral spinal cord. Axon terminals were predominantly found within the lateral motor column and the ventral regions of lamina VII ipsilateral to the injection site. Several axon varicosities made close appositions with somata and dendrites of motoneurons, which were identified as synaptic contacts in a consecutive electron microscopic study. With the postembedding immunogold method, 21 of 97 labeled terminals investigated were immunoreactive for glycine and 2 of them showed immunoreactivity for gamma-aminobutyric acid (GABA). The axon trajectories of neurons within the minor nucleus of Hofmann suggest that some of these cells might represent a population of last-order premotor interneurons
Tárgyszavak:Orvostudományok Elméleti orvostudományok magyar nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Experimental Zoology. - 286 : 2 (2000), p. 157-172. -
További szerzők:Puskár Zita Birinyi András (1960-) (anatómus, neurobiológus) Storm-Mathisen, John
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

2.

001-es BibID:BIBFORM028817
Első szerző:Antal Miklós (orvos, anatómus)
Cím:Development of specific populations of interneurons in the ventral horn of the embryonic chick lumbosacral spinal cord / Antal M., Polgár E., Berki Á., Birinyi A., Puskár Z.
Dátum:1994
Megjegyzések:The development, morphological and neurochemical properties of specific populations of interneurons were investigated in the ventral horn of the embryonic and mature chick lumbosacral spinal cord by using pre- and post-embedding immunocytochemical as well as anterograde axonal tracing techniques. We have identified and traced the morphological maturation of the following cell groups: (1) Neurons immunoreactive for calbindin-D 28k (CaB), a calcium-binding protein that has been reported to be a marker of certain subsets of excitatory spinal neurons. We have distinguished and traced the maturation of three CaB-immunoreactive cell groups in the ventral horn; (2) Neurons immunoreactive for GABA and glycine, the two putative inhibitory amino acid neurotransmitters in the spinal cord; (3) Neurons within the nucleus marginalis, a cell group located in the ventrolateral aspect of the white matter in close proximity to the lateral motor column. The characteristic features of the development of these neurons are discussed and correlated with previous neuroanatomical and physiological studies concerning motor functions in the developing chick spinal cord.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:European Journal of Morphology. - 32 : 2-4 (1994), p. 201-206. -
További szerzők:Polgár E. Berki Á. Birinyi András (1960-) (anatómus, neurobiológus) Puskár Zita
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Borító:

3.

001-es BibID:BIBFORM029495
Első szerző:Birinyi András (anatómus, neurobiológus)
Cím:The extent of the dendritic tree and the number of synapses in the frog motoneuron / Birinyi A., Antal M., Wolf E., Székely G.
Dátum:1992
ISSN:0953-816X
Megjegyzések:Frog motoneurons were intracellularly labelled with cobaltic lysine in the brachial and the lumbar segments of the spinal cord, and the material was processed for light microscopy in serial sections. With the aid of the neuron reconstruction system NEUTRACE, the dendritic tree of neurons was reconstructed and the length and surface area of dendrites measured. The surface of somata was determined with the prolate - oblate average ellipsoid calculation. Corrections were made for shrinkage and for optical distortion. The mean surface area of somata was 6710 microm2; lumbar motoneurons were slightly larger than brachial motoneurons. The mean length of the combined dendritic tree of brachial neurons was 29 408 microm and that of lumbar neurons 46 806 microm. The mean surface area was 127 335 microm2 in brachial neurons, and 168 063 microm2 in lumbar neurons. The soma - dendrite surface area ratio was 3 - 5% in most cases. Dendrites with a diameter of </= 1.0 microm constituted approximately 75% of the combined dendritic length in most of the neurons. Unlike in the cat, there was no correlation between the size of stem dendrites and the extent of daughter branches. From the synaptic density estimated in earlier electron microscope investigations of frog motoneuron dendrites (Antal et al., J. Neurocytol., 15, 303 - 310, 1986; 21, 34 - 49, 1992), and from the present data, the number of synapses on the dendritic tree was calculated. The calculations indicated 26 949 synapses on the smallest and 61 519 synapses on the largest neuron if the synaptic density was multiplied by the length of the dendritic tree. If the synaptic density was multiplied by the surface area of the dendritic tree the calculation yielded 23 337 synapses for the smallest and 60 682 synapses for the largest neuron. More than 60% of the combined surface area of dendrites was >600 microm from the soma. This suggests that about two-thirds of the synapses impinged upon distant dendrites >600 microm from the soma. The efficacy of synapses at these large distances is investigated on model neurons in the accompanying paper
Tárgyszavak:Orvostudományok Természettudományok Biológiai tudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:European Journal Of Neuroscience. - 4 : 11 (1992), p. 1003-1012. -
További szerzők:Antal Miklós (1951-) (orvos, anatómus) Wolf Ervin (1961-) (fizikus, neurobiológus) Székely György (1926-2017) (neurobiológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

4.

001-es BibID:BIBFORM029093
Első szerző:Birinyi András (anatómus, neurobiológus)
Cím:Synaptic targets of commissural interneurons in the lumbar spinal cord of neonatal rats / Birinyi A., Viszokay K., Wéber I., Kiehn O., Antal M.
Dátum:2003
ISSN:0021-9967
Megjegyzések:There is strong evidence that commissural interneurons, neurons with axons that extend to the contralateral side of the spinal cord, play an important role in the coordination of left/right alternation during locomotion. In this study we investigated the projections of commissural interneurons to motor neurons and other commissural interneurons on the other side of the spinal cord in neonatal rats. To establish whether there are direct contacts between axons of commissural interneurons and motor neurons, we carried out two series of experiments. In the first experiment we injected biotinylated dextran amine (BDA) into the lateral motor column to retrogradely label commissural interneurons that may have direct projections to motor neurons. Stained neurons were recovered in the ventromedial areas of the contralateral gray matter in substantial numbers. In the second experiment BDA was injected into the ventromedial gray matter on one side of the lumbar spinal cord, whereas motor neurons were simultaneously labeled on the opposite side by applying biocytin onto the ventral roots. BDA injections into the ventromedial gray matter labeled a strong axon bundle that arose from the site of injection, crossed the midline in the ventral commissure, and extensively arborized in the contralateral ventral gray matter. Many of these axons made close appositions with dendrites and somata of motor neurons and also with commissural interneurons retrogradely labeled with BDA. The results suggest that commissural interneurons may establish monosynaptic contacts with motor neurons on the opposite side of the spinal cord. Our findings also indicate that direct reciprocal connections between commissural interneurons on the two sides of the spinal cord may also exist.
Tárgyszavak:Orvostudományok Elméleti orvostudományok magyar nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Comparative Neurology. - 461 : 4 (2003), p. 429-440. -
További szerzők:Viszokay Kornél Wéber Ildikó (1972-) (biológus, neurobiológus) Kiehn, Ole Antal Miklós (1951-) (orvos, anatómus)
Pályázati támogatás:046121
OTKA
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

5.

001-es BibID:BIBFORM029088
Első szerző:Birinyi András (anatómus, neurobiológus)
Cím:Zinc co-localizes with GABA and glycine in synapses in the lamprey spinal cord / Birinyi A., Parker D., Antal M., Shupliakov O.
Dátum:2001
ISSN:0021-9967
Megjegyzések:The presence of zinc in synaptic terminals in the lamprey spinal cord was examined utilizing a modification of the Timm's sulfide silver method and with the fluorescent marker 6-methoxy-8-quinolyl-p-toluenesulfonamide (TSQ). Axons labeled with a Timm's staining method were predominantly located in the lateral region of the dorsal column. This correlated with a maximum of TSQ fluorescence in this region of the spinal cord. Single labeled terminals accumulating Timm reaction product were also found throughout the gray matter and fiber tracts. At the ultrastructural level, zinc was located in a population of synaptic terminals that co-localized gamma-aminobutyric acid (GABA) and glycine. Possible effects of Zn2+ on neuronal activity were examined. In spinobulbar interneurons, which receive GABAergic input in the dorsal column, zinc potentiated responses to GABA application, but it did not affect responses to GABA in motoneurons. Responses in motoneurons to pressure application of glycine were also not affected by Zn2+. Zinc, however, potentiated monosynaptic glycinergic inhibitory postsynaptic potentials (IPSPs) evoked in motoneurons by inhibitory locomotor network interneurons and increased frequency, but not amplitude of spontaneous miniature IPSPs recorded in the presence of tetrodotoxin (TTX), suggesting presynaptic effects. Glutamate responses and the amplitude of monosynaptic excitatory postsynaptic potentials (EPSPs) in motoneurons were reduced by zinc. These effects appeared to be mediated largely postsynaptically through an effect on the N-methyl-D-aspartate (NMDA) component of the glutamatergic input. Our results thus show that free zinc is present in inhibitory synaptic terminals in the lamprey spinal cord, and that it may function as a modulator of inhibitory synaptic transmission.
Tárgyszavak:Orvostudományok Elméleti orvostudományok magyar nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Comparative Neurology. - 433 : 2 (2001), p. 208-221. -
További szerzők:Parker, David (1960-) (vegyész) Antal Miklós (1951-) (orvos, anatómus) Shupliakov, Oleg
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

6.

001-es BibID:BIBFORM029090
Első szerző:Dityatev, A. E.
Cím:A correlative physiological and morphological analysis of monosynaptically connected propriospinal axon - motoneuron pairs in the lumbar spinal cord of frogs / Dityatev A. E., Birinyi A., Puskár Z., Antal M., Clamann P.
Dátum:2001
ISSN:0306-4522
Megjegyzések:Intracellular stimulation of single propriospinal axons evoked excitatory postsynaptic potentials (EPSPs) in lumbar motoneurons. Mean EPSP amplitudes differed by two orders of magnitude when measured in different connections. After analyzing the distribution of mean amplitudes of 47 single-fiber EPSPs, two populations of responses could be defined: (1) those with mean amplitudes between 0.1 and 1.2 mV (mean+/-S.D.: 0.48+/-0.30 mV, 34 pairs), which is in the range of values typical for single-fiber EPSPs evoked by stimulation of supraspinal fibers and primary muscle afferents, (2) those with mean amplitudes between 1.6 and 8 mV (4.2+/-2.0 mV, 13 pairs). Both populations of responses had similarly short latencies and rise times and responded similarly to paired-pulse stimulation, consistent with monosynaptic transmission. However, the high-efficacy connections had significantly smaller coefficients of variation of EPSPs, as well as increased quantal content and quantal size. Tetanic stimulation gradually depressed the amplitude of large EPSPs by 81-86%, but did not affect small EPSPs. Recovery of large EPSPs was exponential with a time constant of 3-5.6 min. During post-tetanic depression the amplitude ratio between the test and conditioned EPSPs evoked by paired-pulse stimulation was not changed but the coefficient of variation was increased, suggesting that the depression was due to depletion of synaptic vesicles available for release.Intracellular labeling of seven electrophysiologically studied propriospinal axon-motoneuron pairs revealed that the number of axon varicosities establishing close appositions with dendrites of the labeled motoneuron was higher for connections where large-amplitude EPSPs were recorded. These varicosities were more often located on proximal dendrites of motoneurons than those of low-efficacy connections. In addition, the number of boutons in highly effective connections was several times lower than the maximal number of available quanta estimated from physiological data, implying that the large EPSPs may be generated by multivesicular release from presynaptic boutons. We conclude that the efficacy and related mode of use-dependent modulation of propriospinal connections is determined by a number of factors, including the number and position of synaptic contacts and the number of active zones or vesicles available for release.
Tárgyszavak:Orvostudományok Elméleti orvostudományok magyar nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Neuroscience. - 106 : 2 (2001), p. 405-417. -
További szerzők:Birinyi András (1960-) (anatómus, neurobiológus) Puskár Zita Antal Miklós (1951-) (orvos, anatómus) Clamann, P.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

7.

001-es BibID:BIBFORM001430
Első szerző:Wéber Ildikó (biológus, neurobiológus)
Cím:Neurotransmitter systems of commissural interneurons int he lumbar spinal cord of neonatal rats / Wéber I., Veress G., Szűcs P., Antal M., Birinyi A.
Dátum:2007
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Brain Research. - 1178 (2007), p. 65-72. -
További szerzők:Veress Gábor (1971-) (neurobiológus) Szűcs Péter (1974-) (kutatóorvos) Antal Miklós (1951-) (orvos, anatómus) Birinyi András (1960-) (anatómus, neurobiológus)
Pályázati támogatás:046121
OTKA
032075
OTKA
T032075
OTKA
Internet cím:elektronikus változat
DOI
Szerző által megadott URL
Borító:
Rekordok letöltése1 
Corvina könyvtári katalógus v8.2.27 © 2023 Monguz kft. Minden jog fenntartva.