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001-es BibID:	BIBFORM029088
Első szerző:	Birinyi András (anatómus, neurobiológus)
Cím:	Zinc co-localizes with GABA and glycine in synapses in the lamprey spinal cord / Birinyi A., Parker D., Antal M., Shupliakov O.
Dátum:	2001
ISSN:	0021-9967
Megjegyzések:	The presence of zinc in synaptic terminals in the lamprey spinal cord was examined utilizing a modification of the Timm's sulfide silver method and with the fluorescent marker 6-methoxy-8-quinolyl-p-toluenesulfonamide (TSQ). Axons labeled with a Timm's staining method were predominantly located in the lateral region of the dorsal column. This correlated with a maximum of TSQ fluorescence in this region of the spinal cord. Single labeled terminals accumulating Timm reaction product were also found throughout the gray matter and fiber tracts. At the ultrastructural level, zinc was located in a population of synaptic terminals that co-localized gamma-aminobutyric acid (GABA) and glycine. Possible effects of Zn2+ on neuronal activity were examined. In spinobulbar interneurons, which receive GABAergic input in the dorsal column, zinc potentiated responses to GABA application, but it did not affect responses to GABA in motoneurons. Responses in motoneurons to pressure application of glycine were also not affected by Zn2+. Zinc, however, potentiated monosynaptic glycinergic inhibitory postsynaptic potentials (IPSPs) evoked in motoneurons by inhibitory locomotor network interneurons and increased frequency, but not amplitude of spontaneous miniature IPSPs recorded in the presence of tetrodotoxin (TTX), suggesting presynaptic effects. Glutamate responses and the amplitude of monosynaptic excitatory postsynaptic potentials (EPSPs) in motoneurons were reduced by zinc. These effects appeared to be mediated largely postsynaptically through an effect on the N-methyl-D-aspartate (NMDA) component of the glutamatergic input. Our results thus show that free zinc is present in inhibitory synaptic terminals in the lamprey spinal cord, and that it may function as a modulator of inhibitory synaptic transmission.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok magyar nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal Of Comparative Neurology. - 433 : 2 (2001), p. 208-221. -
További szerzők:	Parker, David (1960-) (vegyész) Antal Miklós (1951-) (orvos, anatómus) Shupliakov, Oleg
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001-es BibID:	BIBFORM053829
Első szerző:	Gustafsson, Jenny S.
Cím:	Ultrastructural organization of lamprey reticulospinal synapses in three dimensions / Jenny S. Gustafsson, András Birinyi, John Crum, Mark Ellisman, Lennart Brodin, Oleg Shupliakov
Dátum:	2002
ISSN:	0021-9967
Megjegyzések:	The giant reticulospinal synapse in lamprey provides a unique model to study synaptic vesicle traffic. The axon permits microinjections, and the active zones are often separated from each other, which makes it possible to track vesicle cycling at individual release sites. However, the proportion of reticulospinal synapses with individual active zones ("simple synapses") is unknown and a quantitative description of their organization is lacking. Here, we report such data obtained by serial section analysis, intermediate-voltage electron microscopy, and electron tomography. The simple synapse was the most common type (78%). It consisted of one active zone contacting one dendritic process. The remaining synapses were "complex," mostly containing one vesicle cluster and two to three active zones synapsing with distinct dendritic shafts. Occasional axosomatic synapses with multiple active zones forming synapses with the same cell were also observed. The vast majority of active zones in all synapse types contained both chemical and electrotonic synaptic specializations. Quantitative analysis of simple synapses showed that the majority had active zones with a diameter of 0.8-1.8 microm. The number of synaptic vesicles and the height of the vesicle cluster in middle sections of serially cut synapses correlated with the active zone length within, but not above, this size range. Electron tomography of simple synapses revealed small filaments between the clustered synaptic vesicles. A single vesicle could be in contact with up to 12 filaments. Another type of filament, also associated with synaptic vesicles, emerged from dense projections. Up to six filaments could be traced from one dense projection.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Comparative Neurology. - 450 : 2 (2002), p. 167-182. -
További szerzők:	Birinyi András (1960-) (anatómus, neurobiológus) Crum, John Ellisman, Mark Brodin, Lennart Shupliakov, Oleg
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001-es BibID:	BIBFORM053911
Első szerző:	Shayan, Alexander J.
Cím:	Neurotransmitter levels and synaptic strength at the drosophila larval neuromuscular junction are not altered by mutation in the sluggish-a gene, which encodes proline oxidase and affects adult locomotion / Alexander J. Shayan, Lennart Brodin, Ole P. Ottersen, Andras Birinyi, Caitlin E. Hill, C. K. Govind, Harold L. Atwood, Oleg Shupliakov
Dátum:	2000
ISSN:	0167-7063
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Neurogenetics. - 14 : 3 (2000), p. 165-192. -
További szerzők:	Brodin, Lennart Ottersen, Ole P. Birinyi András (1960-) (anatómus, neurobiológus) Hill, Caitlin E. Govind, C. K. Atwood, Harold L. Shupliakov, Oleg
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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