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001-es BibID:	BIBFORM015615
035-os BibID:	10946767
Első szerző:	Felszeghy Szabolcs Béla (fogorvos, anatómus, kötőszövetbiológus)
Cím:	Quantitative image analysis of hyaluronan expression in human tooth germs / Felszeghy S., Hyttinen, M., Tammi, R., Tammi, M., Modis L.
Dátum:	2000
ISSN:	0909-8836 (Linking)
Megjegyzések:	The expression of hyaluronan in human tooth germs was studied by using abiotinylated hyaluronan-binding complex and quantitative digital image analysis.At the cap stage, dental papilla exhibited a moderate staining, while intensereaction was observed in the apical portion of presecretory ameloblasts, stellatereticulum, and in dental basement membrane. When the enamel and dentine matricesstarted to develop, a strong hyaluronan reaction was evident in the young enameland the apical portion of secretory ameloblasts. No hyaluronan could be detectedin the secretory ameloblasts and enamel matrix of the early (9-wk-old) post-natalstage. It is concluded that hyaluronan may play a transitory role in the earlyphase of the development of the enamel matrix organization. A very weak signalwas observed in the wall of dentin tubules, whereas the rest of the dentinematrix was not stained. The odontoblasts and the pulp were also moderatelystained, and these reactions gradually decreased with age, suggesting thathyaluronan may also contribute to the development of dentine matrix and pulp.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban 0 (Extracellular Matrix Proteins) 9004-61-9 (Hyaluronic Acid) Ameloblasts/metabolism Amelogenesis/physiology Dental Papilla/embryology/metabolism Embryonic and Fetal Development Enamel Organ/embryology/metabolism Extracellular Matrix Proteins/metabolism Humans Hyaluronic Acid/metabolism Image Processing, Computer-Assisted Immunoenzyme Techniques Protein Binding Tooth Germ/embryology/metabolism egyetemen (Magyarországon) készült közlemény
Megjelenés:	European journal of oral sciences. - 108 : 4 (2000), p. 320-326. -
További szerzők:	Hyttinen, Mikka Tammi, Raija (kutatóorvos) Tammi, Markku (kutatóorvos) Módis László (1939-) (anatómus, kötőszövetbiológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM015611
035-os BibID:	11451408
Első szerző:	Felszeghy Szabolcs Béla (fogorvos, anatómus, kötőszövetbiológus)
Cím:	The distribution pattern of the hyaluronan receptor CD44 during human toothdevelopment / Szabolcs Felszeghy, László Módis, Markku Tammi, Raija Tammi
Dátum:	2001
ISSN:	0003-9969 (Linking)
Megjegyzések:	The aim was to investigate the expression pattern of the major cell-surfacehyaluronan receptor CD44, as there are no existing data on its presence orabsence in human dental structures at different developmental stages.Immunohistochemical localization of CD44 was studied using a monoclonal antibody,H3, that specifically recognizes an epitope in the common backbone of all CD44isoforms. The dental lamina displayed a strong CD44 signal; the external enamelepithelium was negative. In the coronal region of the tooth germ the presecretoryameloblasts showed an intense reaction whereas the less differentiated innerenamel epithelial cells showed no signal at the cervical loop where they meet theexternal enamel epithelium. In the stellate reticulum a moderate reaction wasdetected. The secretory ameloblasts and the stratum intermedium showed a strongcell-surface CD44 signal. A strong signal was also observed on the odontoblastsand their processes. In the pulp, close to the odontoblastic layer, weaklabelling was seen in the walls of capillary vessels. The distribution of CD44 inthe human tooth germ corresponds to that of hyaluronan in most locations,suggesting that during tooth development this transmembrane protein plays animportant part in hyaluronan-mediated events.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban 0 (Antibodies, Monoclonal) 0 (Antigens, CD44) Age Factors Ameloblasts/chemistry/metabolism Antibodies, Monoclonal Antigens, CD44/analysis/biosynthesis Embryonic and Fetal Development Humans Immunohistochemistry Infant Infant, Newborn Odontoblasts/chemistry/metabolism Tooth Germ/chemistry/metabolism egyetemen (Magyarországon) készült közlemény
Megjelenés:	Archives of Oral biology. - 46 : 10 (2001), p. 939-945. -
További szerzők:	Módis László (1939-) (anatómus, kötőszövetbiológus) Tammi, Markku (kutatóorvos) Tammi, Raija (kutatóorvos)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat elektronikus elérés DOI
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001-es BibID:	BIBFORM015602
035-os BibID:	16317603
Első szerző:	Klekner Álmos (idegsebész)
Cím:	Quantitative determination of hyaluronan content in cerebral aneurysms by digitaldensitometry / Klekner A., Felszeghy S., Tammi R., Tammi M., Csécsei G., Módis L.
Dátum:	2005
ISSN:	0044-4251 (Linking)
Megjegyzések:	OBJECT: Hyaluronan (HA) is a highly hydrated macromolecule; it is one of theessential components of the extracellular matrix (ECM) of the arteries and playsan important role in maintaining the biomechanical features of blood vessels.Although the potential contribution of HA in aneurysms of different vessels hasbeen studied intensively, no data are available about the alteration of the HAcontent in the extracellular matrix of intracranial aneurysms. The aim of thestudy was to determine the hyaluronan content in the wall of human cerebralarteries. METHODS: A biotinylated aggrecan fragment that binds specifically to HAwas used to stain samples from cerebral aneurysms (n = 11) to compare the HAcontent to non-aneurysmal arteries of patients who had intracranial aneurysm (n =11), and to histologically normal arteries of patients who had expired fromnon-vascular diseases (n = 14). Digital microscopic densitometry was used for thequantitative analysis of the hyaluronan content in these samples. RESULTS: TheCONCLUSIONS: Results suggest that an elevated hyaluronan level in theextracellular matrix may affect the cerebral arterial wall architecture. It isreasonable to suppose that the increased hyaluronan content creates aviscoelastic ECM which might improve the biomechanical resistance of the thinnedvessel wall.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban 9004-61-9 (Hyaluronic Acid) Adult Aged Aged, 80 and over Cerebral Arteries/metabolism/pathology Circle of Willis/metabolism/pathology Densitometry Elasticity Female Histocytochemistry Humans Hyaluronic Acid/metabolism Image Processing, Computer-Assisted Intracranial Aneurysm/*metabolism/pathology Male Middle Aged Viscosity egyetemen (Magyarországon) készült közlemény
Megjelenés:	Zentralblatt fur Neurochirurgie. - 66 : 4 (2005), p. 207-12. -
További szerzők:	Felszeghy Szabolcs Béla (1972-) (fogorvos, anatómus, kötőszövetbiológus) Tammi, Raija (kutatóorvos) Tammi, Markku (kutatóorvos) Csécsei György (1948-2005) (idegsebész) Módis László (1939-) (anatómus, kötőszövetbiológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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