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001-es BibID:BIBFORM015602
035-os BibID:16317603
Első szerző:Klekner Álmos (idegsebész)
Cím:Quantitative determination of hyaluronan content in cerebral aneurysms by digitaldensitometry / Klekner A., Felszeghy S., Tammi R., Tammi M., Csécsei G., Módis L.
Dátum:2005
ISSN:0044-4251 (Linking)
Megjegyzések:OBJECT: Hyaluronan (HA) is a highly hydrated macromolecule; it is one of theessential components of the extracellular matrix (ECM) of the arteries and playsan important role in maintaining the biomechanical features of blood vessels.Although the potential contribution of HA in aneurysms of different vessels hasbeen studied intensively, no data are available about the alteration of the HAcontent in the extracellular matrix of intracranial aneurysms. The aim of thestudy was to determine the hyaluronan content in the wall of human cerebralarteries. METHODS: A biotinylated aggrecan fragment that binds specifically to HAwas used to stain samples from cerebral aneurysms (n = 11) to compare the HAcontent to non-aneurysmal arteries of patients who had intracranial aneurysm (n =11), and to histologically normal arteries of patients who had expired fromnon-vascular diseases (n = 14). Digital microscopic densitometry was used for thequantitative analysis of the hyaluronan content in these samples. RESULTS: TheCONCLUSIONS: Results suggest that an elevated hyaluronan level in theextracellular matrix may affect the cerebral arterial wall architecture. It isreasonable to suppose that the increased hyaluronan content creates aviscoelastic ECM which might improve the biomechanical resistance of the thinnedvessel wall.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
9004-61-9 (Hyaluronic Acid)
Adult
Aged
Aged, 80 and over
Cerebral Arteries/*metabolism/pathology
Circle of Willis/metabolism/pathology
Densitometry
Elasticity
Female
Histocytochemistry
Humans
Hyaluronic Acid/*metabolism
Image Processing, Computer-Assisted
Intracranial Aneurysm/*metabolism/pathology
Male
Middle Aged
Viscosity
egyetemen (Magyarországon) készült közlemény
Megjelenés:Zentralblatt fur Neurochirurgie. - 66 : 4 (2005), p. 207-12. -
További szerzők:Felszeghy Szabolcs Béla (1972-) (fogorvos, anatómus, kötőszövetbiológus) Tammi, Raija (kutatóorvos) Tammi, Markku (kutatóorvos) Csécsei György (1948-2005) (idegsebész) Módis László (1939-) (anatómus, kötőszövetbiológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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