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001-es BibID:BIBFORM091925
035-os BibID:(cikkazonosító)2297 (scopus)85101368515 (wos)000628289100001
Első szerző:Varga Angelika (biológus)
Cím:Spinal Excitatory Dynorphinergic Interneurons Contribute to Burn Injury-Induced Nociception Mediated by Phosphorylated Histone 3 at Serine 10 in Rodents / Varga Angelika, Mészár Zoltán, Sivadó Miklós, Bácskai Tímea, Végh Bence, Kókai Éva, Nagy István, Szücs Péter
Dátum:2021
ISSN:1661-6596 1422-0067
Megjegyzések:The phosphorylation of serine 10 in histone 3 (p-S10H3) has recently been demonstrated to participate in spinal nociceptive processing. However, superficial dorsal horn (SDH) neurons involved in p-S10H3-mediated nociception have not been fully characterized. In the present work, we combined immunohistochemistry, in situ hybridization with the retrograde labeling of projection neurons to reveal the subset of dorsal horn neurons presenting an elevated level of p-S10H3 in response to noxious heat (60 ?C), causing burn injury. Projection neurons only represented a small percentage (5%) of p-S10H3-positive cells, while the greater part of them belonged to excitatory SDH interneurons. The combined immunolabeling of p-S10H3 with markers of already established interneuronal classes of the SDH revealed that the largest subset of neurons with burn injury-induced p-S10H3 expression was dynorphin immunopositive in mice. Furthermore, the majority of p-S10H3-expressing dynorphinergic neurons proved to be excitatory, as they lacked Pax-2 and showed Lmx1b-immunopositivity. Thus, we showed that neurochemically heterogeneous SDH neurons exhibit the upregulation of p-S10H3 shortly after noxious heat-induced burn injury and consequential tissue damage, and that a dedicated subset of excitatory dynorphinergic neurons is likely a key player in the development of central sensitization via the p-S10H3 mediated pathway.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
histone
epigenetic modification
superficial dorsal horn neuron
burn injury
neuropeptides
nociception
Megjelenés:International Journal Of Molecular Sciences. - 22 : 5 (2021), p. 1-28. -
További szerzők:Mészár Zoltán Mihály (1977-) (agrármérnök) Sivadó Miklós Bácskai Tímea (1974-) (biológus, neurobiológus) Végh Bence Kókai Éva (1989-) (molekuláris biológus) Nagy István (orvos) Szűcs Péter (1974-) (kutatóorvos)
Pályázati támogatás:FK_125035
OTKA
ÚNKP18-4-DE-70
Egyéb
ÚNKP-19-4-DE-3
Egyéb
ÚNKP-17-3/I
Egyéb
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2.

001-es BibID:BIBFORM040293
Első szerző:Veress Gábor (neurobiológus)
Cím:Characterisation of cannabinoid 1 receptor expression in the perikarya, and peripheral and spinal processes of primary sensory neurons / Veress Gabor, Meszar Zoltan, Muszil Dora, Avelino Antonio, Matesz Klara, Mackie Ken, Nagy Istvan
Dátum:2013
ISSN:1863-2653
Megjegyzések:The cannabinoid 1 (CB1) receptor is expressed by a sub-population of primary sensory neurons. However, data on the neurochemical identity of the CB1 receptor-expressing cells, and CB1 receptor expression by the peripheral and central terminals of these neurons are inconsistent and limited. We characterised CB1 receptor expression in dorsal root ganglia (DRG) and spinal cord at the lumbar 4-5 level, as well as in the urinary bladder and glabrous skin of the hindpaw. About 1/3 of DRG neurons exhibited immunopositivity for the CB1 receptor, the majority of which showed positivity for the nociceptive markers calcitonin gene-related peptide (CGRP) or/and Griffonia (bandeiraea) simplicifolia IB4 isolectin-binding. Virtually all CB1 receptor-immunostained fibres showed immunopositivity for CGRP in the skin, while very few did in the urinary bladder. No CB1 receptor-immunopositive nerve fibres were IB4 positive in either peripheral tissue. Spinal laminae I and II-outer showed the highest density of CB1 receptor-immunopositive punctae, the majority of which showed positivity for CGRP or/and IB4 binding. These data indicate that a major sub-population of nociceptive primary sensory neurons expresses CB1 receptors that are transported to both peripheral and central terminals of these cells. Therefore, the present data suggest that manipulation of endogenous CB1 receptor agonist levels in these areas may significantly reduce nociceptive input into the spinal cord.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Brain Structure & Function. - 218 : 3 (2013), p. 733-750. -
További szerzők:Mészár Zoltán Mihály (1977-) (agrármérnök) Muszil Dóra Avelino, Antonio Matesz Klára (1949-) (anatómus, neurobiológus) Mackie, Ken Nagy István (orvos)
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Intézményi repozitóriumban (DEA) tárolt változat
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