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001-es BibID:	BIBFORM042910
Első szerző:	Thirunavukkarasu, Mahesh
Cím:	Enhanced cardiovascular function and energy level by a novel chromium (III)-supplement / Thirunavukkarasu M., Penumathsa S., Juhasz B., Zhan L., Bagchi M., Yasmin T., Shara M. A., Thatte H. S., Bagchi D., Maulik N.
Dátum:	2006
ISSN:	0951-6433
Megjegyzések:	The impetus for the novel Energy Formula (EF) which combines the niacin-bound chromium (III) (0.45%) (NBC), standardized extract of Withania somnifera extracts (10.71%), caffeine (22.76%), D-ribose (10.71%) and selected amino acids such as phenylalanine, taurine and glutamine (55.37%) was based on the knowledge of the cardioprotective potentials of the Withania somnifera extract, caffeine and D-ribose as well as their abilities to increase energy levels and the abilities of amino acids to increase the muscle mass and energy levels. The effect of oral supplementation of EF on the safety, myocardial energy levels and cardioprotective ability were investigated in an ischemic-reperfused myocardium model in both male and female Sprague-Dawley rats over 90 days trial period. At the completion of 90 days, the EF-treated male and female rats gained 9.4% and 3.1% less body weights, respectively, as compared to their corresponding control groups. No significant difference was found in the levels of lipid peroxidation and activities of hepatic Aspartate transaminase, Alanine transaminase and Alkaline phosphatase in EF treatment when compared with control animals. The male and female rat hearts were subjected to 30 min of global ischemia followed by 2 h of reperfusion at 30 and 90 days of EF treatment. Cardiovascular functions including heart rate, coronary flow, aortic flow, dp/dt(max), left ventricular developed pressure (LVDP) and infarct size were monitored. The levels of myocardial adenosine triphosphate (ATP), creatine phosphate (CP), phospho-adenosine monophosphate kinase (p-AMPK) levels, were analyzed at the end of 30 and 90 days of treatment. Significant improvement was observed in all parameters in the EF treatment groups as compared to their corresponding controls. Thus the niacin-bound chromium (III) based energy formula is safe and effective supplement to boost energy levels and cardioprotection.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Biofactors. - 27 : 1-4 (2006), p. 53-67. -
További szerzők:	Penumathsa, Suresh Varma Juhász Béla (1978-) (kísérletes farmakológus) Zhan, Lijun Bagchi, Manashi Yasmin, Taharat Shara, Michael A. Thatte, Hemant S. Bagchi, Debasis Maulik, Nilanjana
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM042912
Első szerző:	Thirunavukkarasu, Mahesh
Cím:	Niacin-bound chromium enhances myocardial protection from ischemia-reperfusion injury / Thirunavukkarasu M., Penumathsa S. V., Juhasz B., Zhan L., Cordis G., Altaf E., Bagchi M., Bagchi D., Maulik N.
Dátum:	2006
ISSN:	0363-6135
Megjegyzések:	A novel niacin-bound, chromium-based energy formula (EF; InterHealth Nutraceuticals, Benicia, CA) has been developed in conjunction with D-ribose, caffeine, ashwagandha extract (containing 5% withanolides), and selected amino acids. We have assessed the efficacy of oral administration of EF (40 mg x kg body wt(-1) x day(-1)) in male and female rats over a period of 90 consecutive days on the cardiovascular and pathophysiological functions in an isolated rat heart model. After 30, 60, and 90 days of treatment with EF, the hearts of male and female rats were subjected to 30 min of global ischemia followed by 2 h of reperfusion and were measured for myocardial ATP, creatine phosphate (CP), phosphorylated AMP kinase (p-AMPK), and heat shock proteins. Myocardial ATP and CP levels were increased in both male and female rats after EF treatment compared with the controls. Western blot analyses were performed to quantify the expression of stress-related proteins such as heat shock proteins (HSP-70, -32, and -25) and are found to be increased in both male and female rats after EF treatment. The p-AMPK level, which is a sensor for the energy state in various cell types, was also found to be increased after treatment with EF in both male and female rats. Aortic flow, maximum first derivative of developed pressure, left ventricular developed pressure, and infarct size were observed after ischemia-reperfusion and found to be significantly improved in EF-treated rats compared with control animals. Thus EF demonstrated long-term safety as well as exhibiting significant cardioprotective ability during ischemia and reperfusion injury by increased energy production, improved cardiac function, and reduced infarct size.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	American Journal Of Physiology-Heart And Circulatory Physiology. - 291 : 2 (2006), p. H820-826. -
További szerzők:	Penumathsa, Suresh Varma Juhász Béla (1978-) (kísérletes farmakológus) Zhan, Lijun Cordis, Gerald A. Altaf, Elham Bagchi, Manashi Bagchi, Debasis Maulik, Nilanjana
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM002227
Első szerző:	Thirunavukkarasu, Mahesh
Cím:	Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes : role of nitric oxide, thioredoxin, and heme oxygenase / Mahesh Thirunavukkarasu, Suresh Varma Penumathsa, Srikanth Koneru, Bela Juhasz, Lijun Zhan, Hajime Otani, Debasis Bagchi, Dipak K. Das, Nilanjana Maulik
Dátum:	2007
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Free Radical Biology and Medicine. - 43 : 5 (2007), p. 720-729. -
További szerzők:	Penumathsa, Suresh Varma Koneru, Srikanth Juhász Béla (1978-) (kísérletes farmakológus) Zhan, Lijun Otani, Hajime Bagchi, Debasis Das, Dipak Kumar Maulik, Nilanjana
Internet cím:	elektronikus változat DOI
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