CCL

Összesen 4 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM081710
035-os BibID:(WOS)000470919300008 (Scopus)85064476443
Első szerző:Bács Zoltán (agrármérnök)
Cím:Effect of broth from meat of linseed-fed cattle on glucose-stimulated insulin release in healthy male volunteers / Bacs Zoltan, Szabo Katalin, Czegledi Levente, Nemeth Jozsef, Fraknoi Peter, Kovacs Peter, Javor Andras, Varga Balazs, Juhasz Bela, Szilvassy Zoltan
Dátum:2019
ISSN:1344-3941 1740-0929
Megjegyzések:Polyunsaturated fatty acid consumption has been shown to improve insulin sensitivity. We studied if administration of broth with beef meat enriched with polyunsaturated fatty acids influenced glucose-stimulated insulin release in healthy male volunteers. Broth was made either from cattles undergone dietary supplementation with lightly bruised whole linseed in addition to feeding ad libitum on grass silage (test meal) or from those fed grass silage alone (control meal). Oral glucose tolerance tests (OGTT) were performed in patients after a 6-day period of eating 300 ml broth containing 100 g meat once a day in addition to their otherwise normal mixed nourishment. During OGTT, blood samples were taken for blood glucose level and plasma insulin immunoreactivity before and 15, 30, 60, 90, 120, and 180 min after the glucose load. Glucose-stimulated maximum increase in plasma insulin immunoreactivity was 42 ? 6.6 and 81 ? 7.4 mU/ml (p < 0.05) after the test and the control meals, respectively. However, both fasting and postload blood glucose levels were the same after either meal period. The results suggest an insulin-sensitizing effect of food produced from beef cattle maintained on linseed diet in healthy human volunteers.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
beef
fatty acid
flax
glucose
insulin
Megjelenés:Animal Science Journal. - 90 : 6 (2019), p. 769-773. -
További szerzők:Szabó Katalin (1989-) (táplálkozástudományi szakember) Czeglédi Levente (1977-) (agrármérnök) Németh József (1954-) (vegyész, analitikus) Fraknói Péter Kovács Péter (1947-) (belgyógyász, kardiológus, klinikai farmakológus) Jávor András (1952-) (agrármérnök) Varga Balázs (1984-) (kísérletes farmakológus) Juhász Béla (1978-) (kísérletes farmakológus) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
Pályázati támogatás:GINOP-2.3.2-15-2016-00062
GINOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM074794
035-os BibID:(WoS)000447365100097 (Scopus)85052651287
Első szerző:Erdei Tamás Dániel (kísérletes farmakológus)
Cím:FSCPX, a chemical widely used as an irreversible A1 adenosine receptor antagonist, modifies the effect of NBTI, a nucleoside transport inhibitor, by reducing the interstitial adenosine level in the guinea pig atrium / Tamas Erdei, Adrienn Monika Szabo, Nora Lampe, Katalin Szabo, Rita Kiss, Judit Zsuga, Csaba Papp, Akos Pinter, Andras Jozsef Szentmiklosi, Zoltan Szilvassy, Bela Juhasz, Rudolf Gesztelyi
Dátum:2018
ISSN:1420-3049
Megjegyzések:Based on in silico results, recently we have assumed that FSCPX, an irreversible A1 adenosine receptor antagonist, inhibits the action of NBTI that is apparent on E/c curves of adenosine receptor agonists. As a mechanism for this unexpected effect, we hypothesized that FSCPX might modify the equilibrative and NBTI-sensitive nucleoside transporter (ENT1) in a way that it allows ENT1 to transport adenosine but impedes NBTI to inhibit this transport. This assumption implies that our method developed to estimate receptor reserve for agonists with short half-life such as adenosine, in its original form, overestimates the receptor reserve. In this study, therefore, our goals were to experimentally test our assumption on this effect of FSCPX, to improve our receptor reserve-estimating method, and then to compare the original and improved forms of this method. Thus, we improved our method and assessed the receptor reserve for the direct negative inotropic effect of adenosine with both forms of this method in guinea pig atria. We have found that FSCPX inhibits the effects of NBTI that are mediated by increasing the interstitial concentration of adenosine of endogenous (but not exogenous) origin. As a mechanism for this action of FSCPX, inhibition of enzymes participating in the interstitial adenosine production can be hypothesized, while modification of ENT1 can be excluded. Furthermore, we have shown that, in comparison with the improved form, the original version of our method overestimates receptor reserve, but only to a small extent. Nevertheless, use of the improved form is recommended in the future.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
adenosine
CPA
FSCPX
NBTI
A1 adenosine receptor
receptorial responsiveness method
atrium
Megjelenés:Molecules. - 23 : 9 (2018), p. 1-17. -
További szerzők:Szabó Adrienn Mónika (1982-) (orvos) Lampé Nóra Szabó Katalin (1989-) (táplálkozástudományi szakember) Kiss Rita (1974-) (laboratóriumi diagnosztika szakorvos) Zsuga Judit (1973-) (neurológus, pszichoterapeuta, egészségügyi szakmanager) Papp Csaba (1966-) (aneszteziológus és intenzív terápiás szakorvos) Pintér Ákos (1967-) (matematikus) Szentmiklósi József András (1948-) (farmakológus, klinikai laboratóriumi szakorvos) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Juhász Béla (1978-) (kísérletes farmakológus) Gesztelyi Rudolf (1969-) (kísérletes farmakológus)
Pályázati támogatás:EFOP-3.6.2-16-2017-00015
EFOP
GINOP-2.3.2-15-2016-00043
GINOP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Szerző által megadott URL
Borító:

3.

001-es BibID:BIBFORM072627
035-os BibID:(cikkazonosító)771 (scopus)85043576366 (wos)000428309800128
Első szerző:Kiss Rita (laboratóriumi diagnosztika szakorvos)
Cím:Insulin-Sensitizer Effects of Fenugreek Seeds in Parallel with Changes in Plasma MCH Levels in Healthy Volunteers / Kiss Rita, Szabó Katalin, Gesztelyi Rudolf, Somodi Sándor, Kovács Péter, Szabó Zoltán, Németh József, Priksz Dániel, Kurucz Andrea, Juhász Béla, Szilvássy Zoltán
Dátum:2018
ISSN:1661-6596 1422-0067
Megjegyzések:In developed, developing and low-income countries alike, type 2 diabetes mellitus (T2DM)is one of the most common chronic diseases, the severity of which is substantially a consequenceof multiple organ complications that occur due to long-term progression of the disease beforediagnosis and treatment. Despite enormous investment into the characterization of the disease, itslong-term management remains problematic, with those afflicted enduring significant degradationin quality-of-life. Current research efforts into the etiology and pathogenesis of T2DM, are focusedon defining aberrations in cellular physiology that result in development of insulin resistance andstrategies for increasing insulin sensitivity, along with downstream effects on T2DM pathogenesis.Ongoing use of plant-derived naturally occurring materials to delay the onset of the disease oralleviate symptoms is viewed by clinicians as particularly desirable due to well-established efficacyand minimal toxicity of such preparations, along with generally lower per-patient costs, in comparisonto many modern pharmaceuticals. A particularly attractive candidate in this respect, is fenugreek,a plant that has been used as a flavouring in human diet through recorded history. The presentstudy assessed the insulin-sensitizing effect of fenugreek seeds in a cohort of human volunteers, andtested a hypothesis that melanin-concentrating hormone (MCH) acts as a critical determinant ofthis effect. A test of the hypothesis was undertaken using a hyperinsulinemic euglycemic glucoseclamp approach to assess insulin sensitivity in response to oral administration of a fenugreek seedpreparation to healthy subjects. Outcomes of these evaluations demonstrated significant improvementin glucose tolerance, especially in patients with impaired glucose responses. Outcome data furthersuggested that fenugreek seed intake-mediated improvement in insulin sensitivity correlated withreduction in MCH levels.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
hyperinsulinemic euglycemic glucose clamp (HEGC)
fenugreek
melanin-concentrating hormone (MCH)
RIA
type 2 diabetes
clinical pilot study
Megjelenés:International Journal Of Molecular Sciences. - 19 : 3 (2018), p. 1-17. -
További szerzők:Szabó Katalin (1989-) (táplálkozástudományi szakember) Gesztelyi Rudolf (1969-) (kísérletes farmakológus) Somodi Sándor (1977-) (belgyógyász) Kovács Péter (1947-) (belgyógyász, kardiológus, klinikai farmakológus) Szabó Zoltán (1973-) (belgyógyász, kardiológus) Németh József (1954-) (vegyész, analitikus) Priksz Dániel (1989-) (farmakológus) Kurucz Andrea (1984-) (orvos) Juhász Béla (1978-) (kísérletes farmakológus) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
Pályázati támogatás:GINOP-2.3.4-15-2016-00002
GINOP
AGR-PIAC-13-1-2013-0008
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

4.

001-es BibID:BIBFORM072717
035-os BibID:(cikkazonosító)798 (scopus)85044144649 (wos)000428309800155
Első szerző:Szabó Katalin (táplálkozástudományi szakember)
Cím:Fenugreek (Trigonella Foenum-Graecum) Seed Flour and Diosgenin Preserve Endothelium-Dependent Arterial Relaxation in a Rat Model of Early-Stage Metabolic Syndrome / Katalin Szabó, Rudolf Gesztelyi, Nóra Lampé, Rita Kiss, Judit Remenyik, Georgina Pesti-Asbóth, Dániel Priksz, Zoltán Szilvássy, Béla Juhász
Dátum:2018
ISSN:1661-6596 1422-0067
Megjegyzések:Fenugreek is a common herb possessing several bioactive components includingdiosgenin. Here, dietary fenugreek seed flour and diosgenin were evaluated on a model ofendothelium-dependent vasorelaxation by abdominal aortas isolated from rats receiving high-fat,high-sugar diet (HFHSD). 60 male Wistar rats were randomized into six groups: (i) negative controlgetting conventional rat feed regimen; (ii) positive control receiving HFHSD; (iii) a test group fed2 g/kg bw/day fenugreek seed flour (containing 10 mg/kg bw/day diosgenin) + HFHSD; (iv) threetest groups fed 1, 10 and 50 mg/kg bw/day diosgenin + HFHSD. Alimentary treatments werecarried out for six weeks. The abdominal aortas were isolated, and 2 mm wide rings were sectionedoff and mounted at a resting tension of 10 mN in organ baths containing Krebs solution (36 ?C)exposed to 95% O2 and 5% CO2. After 60-min incubation, a norepinephrine concentration-response(E/c) curve was generated to determine their half-maximal effective concentration (EC50) value.After 60-min wash-out, a pre-contraction with norepinephrine EC50 was made, followed by anacetylcholine E/c curve. Plasma glutathione levels, glutathione-handling enzyme activities and bloodantioxidant capacities were also determined. HFHSD significantly decreased the dilatory response toacetylcholine and increased plasma glutathione levels and these effects were significantly reversed byfenugreek seed flour, 10 and 50 mg/kg bw/day diosgenin. Both fenugreek and diosgenin treatmentsprevent HFHSD-induced endothelial dysfunction and redox changes. As fenugreek treatmentwas more effective at lower acetylcholine concentrations than diosgenin treatments, components offenugreek other than diosgenin may contribute to the beneficial effects of dietary fenugreek seed flour.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
endothelial dysfunction
metabolic syndrome
obesity
type 2 diabetes mellitus
fenugreek
Trigonella foenum-graecum
diosgenin
endothelium-dependent vasorelaxation
Wistar rat
Megjelenés:International Journal of Molecular Sciences. - 19 : 3 (2018), p. 1-21. -
További szerzők:Gesztelyi Rudolf (1969-) (kísérletes farmakológus) Lampé Nóra Kiss Rita (1974-) (laboratóriumi diagnosztika szakorvos) Gálné Remenyik Judit (1965-) (kémia tanár, okleveles vegyész) Pesti-Asbóth Georgina (1990-) (élelmiszerbiztonsági és -minőségi mérnök) Priksz Dániel (1989-) (farmakológus) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Juhász Béla (1978-) (kísérletes farmakológus)
Pályázati támogatás:GINOP-2.3.2-15-2016-00062
GINOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1