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001-es BibID:	BIBFORM019281
Első szerző:	Soltész Pál (belgyógyász, kardiológus)
Cím:	Evaluation of antibodies to oxidized low-density lipoprotein and assessment of C-reactive protein in acute coronary syndrome and stable coronary artery disease / Soltesz Pal, Veres Katalin, Laczik Renata, Der Henrietta, Csipo Istvan, Timar Orsolya, Szomjak Edit, Szegedi Gyula, Szodoray Peter
Dátum:	2007
ISSN:	0340-6245
Megjegyzések:	The aim was to measure the level of antibodies to oxidized LDL (oxLDL) and C-reactive protein (CRP) in the serum of patients with acute coronary syndrome (ACS). The results were correlated with data obtained from patients with stable coronary artery disease (stable CAD) and healthy controls.Thirty-three patients with ACS and 62 stable CAD patients were enrolled in the study. Fifty healthy individuals served as controls.The evaluation of anti-oxLDL autoantibodies was performed by ELISA, while CRP levels were measured by turbidimetry. The level of antibodies to oxLDL was significantly higher in both groups of patients with ACS and stable CAD compared to controls.The comparison between the acute and stable groups showed that anti-oxLDL levels were higher in the acute group,but because of high SD, the difference was not significant. By performing group analysis, anti-oxLDL levels were found to be significantly higher in ACS patients with unstable clinical state (circulatory insufficiency, malignant arrhythmias, recurring ischemic pain, need for urgent coronary intervention and death). CRP level in patients with ACS was significantly higher than in those with stable CAD. A positive correlation was found between anti-oxLDL antibodies and CRP levels both in patients with ACS and stable CAD. The association between the two biomarkers was stronger in the ACS group. In conclusion, our findings support the notion that the presence of antibodies to oxLDL, a plaquespecific antigen, plays a major role as a predictor of complicated manifestations of ACS.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Thrombosis And Haemostasis. - 98 : 2 (2007), p. 413-419. -
További szerzők:	Veres Katalin (1971-) (orvos) Laczik Renáta (1982-) (orvos) Dér Henrietta (1977-) (orvos) Csípő István (1953-) (vegyész) Tímár Orsolya (1980-) (belgyógyász) Szomják Edit (1961-) (belgyógyász) Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Szodoray Péter (1973-) (belgyógyász, orvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM013921
Első szerző:	Soltész Pál (belgyógyász, kardiológus)
Cím:	Comparative assessment of vascular function in autoimmune rheumatic diseases : consideration of prevention and treatment / Soltész Pál, Kerekes György, Dér Henrietta, Szűcs Gabriella, Szántó Sándor, Kiss Emese, Bodolay Edit, Zeher Margit, Tímár Orsolya, Szodoray Péter, Szegedi Gyula, Szekanecz Zoltán
Dátum:	2011
ISSN:	1568-9972
Megjegyzések:	Numerous autoimmune-inflammatory rheumatic diseases have been associated with accelerated atherosclerosis or other types of vasculopathy leading to increased cardio- and cerebrovascular disease risk. Traditional risk factors, as well as the role of systemic inflammation including cytokines, chemokines, proteases, autoantibodies, adhesion receptors and others have been implicated in the development of these vascular pathologies. The characteristics of vasculopathies may significantly differ depending on the underlying disease. While classical accelerated atherosclerosis has been associated with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) or spondyloarthropathies (SpA), obliterative vasculopathy may rather be characteristic for systemic sclerosis (SSc) or mixed connective tissue disease (MCTD). Antiphospholipid antibodies have been implicated in vasculopathies underlying SLE, antiphospholipid syndrome (APS), RA and MCTD. There is also heterogeneity with respect to inflammatory risk factors. Cytokines, such as tumor necrosis factor-alpha (TNF-alpha) or interleukin 6 (IL-6) and immune complexes are primarily involved in arthritides, such as RA, SpA, as well as in SLE. On the other hand, autoantibodies including anti-oxLDL anti-cardiolipin and anti-beta2GPI are rather involved in SLE- and APS-associated vasculopathies. Regarding the non-invasive assessment of vascular function, endothelial dysfunction, overt atherosclerosis and vascular stiffness may be indicated by brachial artery flow-mediated vasodilation (FMD), common carotid intima-media thickness (ccIMT) and aortic pulse-wave velocity (PWV), respectively. These abnormalities have been described in most inflammatory rheumatic diseases. While ccIMT and stiffness are relatively stable, FMD may be influenced by many confounding factors. In addition to traditional vasculoprotection, immunosuppressive agents including corticosteroids, traditional and biologic DMARDs may have significant vascular and metabolic effects. The official EULAR recommendations on the assessment and management of cardiovascular disease in arthritides have just been published, and similar recommendations in connective tissue diseases are to be developed soon.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Autoimmunity Reviews. - 10 : 7 (2011), p. 416-425. -
További szerzők:	Kerekes György (1973-) (belgyógyász, kardiológus, angiológus) Dér Henrietta (1977-) (orvos) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Szántó Sándor (1968-) (belgyógyász, reumatológus) Kiss Emese (1960-) (belgyógyász, immunológus) Bodolay Edit (1950-) (belgyógyász, allergológus és klinikai immunológus) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Tímár Orsolya (1980-) (belgyógyász) Szodoray Péter (1973-) (belgyógyász, orvos) Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI elektronikus változat
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001-es BibID:	BIBFORM033337
Első szerző:	Szodoray Péter (belgyógyász, orvos)
Cím:	TH1/TH2 imbalance, measured by circulating and intracytoplasmic inflammatory cytokines - immunological alterations in acute coronary syndrome and stable coronary artery disease / P. Szodoray, O. Timar, K. Veres, H. Der, E. Szomjak, G. Lakos, M. Aleksza, B. Nakken, G. Szegedi, P. Soltesz
Dátum:	2006
ISSN:	0300-9475
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Scandinavian Journal of Immunology. - 64 : 3 (2006), p. 336-344. -
További szerzők:	Tímár Orsolya (1980-) (belgyógyász) Veres Katalin (1971-) (orvos) Dér Henrietta (1977-) (orvos) Szomják Edit (1961-) (belgyógyász) Lakos Gabriella (1963-) (laboratóriumi szakorvos, transzfúziológus, immunológus) Aleksza Magdolna Nakken, Britt Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Soltész Pál (1961-) (belgyógyász, kardiológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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