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001-es BibID:BIBFORM037300
Első szerző:Das, Somak
Cím:Tocotrienols confer resistance to ischemia in hypercholesterolemic hearts : insight with genomics / Das Somak, Mukherjee Subhendu, Lekli Istvan, Gurusamy Narasimman, Bardhan Jayeeta, Raychoudhury Utpal, Chakravarty Runu, Banerji Sandip, Knowlton Anne A., Das Dipak K.
Dátum:2012
ISSN:0300-8177
Megjegyzések:Most clinical trials with vitamin E could not lower cholesterol and thus, have been deemed unsuccessful. Recently, tocotrienols, isomers of vitamin E have been found to lower LDL levels. To explore if tocotrienols could be the drug target for vitamin E, rabbits were kept on cholesterol diet for 60 days supplemented with tocotrienol-alpha, tocotrienol-delta, and tocotrienol-gamma for the last 30 days. The serum cholesterol levels (in mmol/l) were 24.4 (tocotrienol-alpha), 34.9 (tocotrienol-delta), 19.8 (tocotrienol-gamma) vs. 39.7 (control). Left ventricular function including aortic flow and developed pressure exhibited significantly improved recovery with tocotrienol-gamma and -alpha, but not with tocotrienol-delta. The myocardial infarct size showed a similar pattern: 33% (tocotrienol-alpha), 23% (tocotrienol-gamma), and 47% (tocotrienol-delta). To examine the molecular mechanisms of cardioprotective effects, gene expression profile was determined using Atlas 1.2/1.2II followed by determination of gene profiles using PedQuest 8.3 software. Based on genomic profiles, the following cholesterol-related proteins were examined: FABP, TGF-beta (cholesterol suppresses TGF-beta), ET-1 (increased by hypercholesterolemia), SPOT 14 (linked with hypercholesterolemia), and matrix metalloproteinase (MMP) 2 and MMP9 (cholesterol regulates MMP2 and MMP9 expression) in the heart. Consistent with the cardioprotective effects of tocotrienol-alpha and -gamma, these two isomers reduced ET-1, decreased MMP2 and MM9, increased TGF-beta and reduced SPOT 14, while tocotrienol-delta had no effects. The results of the present study demonstrate that the two isomers of tocotrienols, alpha and gamma, render the hypercholesterolemic hearts resistant to ischemic reperfusion injury by lowering several hypercholesterolemic proteins including MMP2, MMP9, ET-1, and SPOT 14 and upregulating TGF-beta.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Molecular And Cellular Biochemistry. - 360 : 1-2 (2012), p. 35-45. -
További szerzők:Mukherjee, Subhendu Lekli István (1981-) (gyógyszerész) Gurusamy, Narasimman Bardhan, Jayeeta Raychaudhuri, Utpal Chakravarty, Runu Banerji, Sandip Knowlton, Anne A. Das, Dipak Kumar
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001-es BibID:BIBFORM014451
Első szerző:Mukherjee, Subhendu
Cím:Comparison of the protective effects of steamed and cooked broccolis on ischaemia-reperfusion-induced cardiac injury / Subhendu Mukherjee, Istvan Lekli, Diptarka Ray, Hiranmoy Gangopadhyay, Utpal Raychaudhuri, Dipak K. Das
Dátum:2010
ISSN:0007-1145
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal Of Nutrition. - 103 : 06 (2010), p. 815-823. -
További szerzők:Lekli István (1981-) (gyógyszerész) Ray, Diptarka Gangopadhyay, Hiranmoy Raychaudhuri, Utpal Das, Dipak Kumar
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