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001-es BibID:BIBFORM037920
Első szerző:Kalantari, Heybatullah
Cím:Protective effect of Cassia fistula fruit extract against bromobenzene-induced liver injury in mice / Kalantari, H., Jalali, M., Jalali, A., Mahdavinia, M., Salimi, A., Juhasz, B., Tosaki, A., Gesztelyi, R.
Dátum:2011
ISSN:0960-3271
Megjegyzések:In the present study, hepatoprotective effect of Cassia fistula fruit extract was investigated in mice. Animals were divided into six groups receiving normal saline (1), bromobenzene (460 mg/kg) alone (2) and together with increasing doses (200, 400, 600, 800 mg/kg) of a crude hydro-alcoholic extract of Cassia fistula fruit (3-6, respectively). All administrations were carried out orally, daily, for 10 days. On the 11th day, animals were sacrificed. Serum activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma glutamyl transpeptidase (?GT) were determined; serum levels of direct and total bilirubin were measured; furthermore, livers were prepared for histological examination. Our results showed that bromobenzene treatment alone elicited a significant increase in activities of AST, ALT, ALP (but not ?GT), and it significantly elevated the levels of direct and total bilirubin. Co-treatment with Cassia fistula fruit extract, however, significantly and dose-dependently decreased the above-mentioned enzyme activities (with exception of ?GT) and bilirubin levels, producing a recovery to the naive state. The protective effect of Cassia fistula fruit extract against liver injury evoked by bromobenzene was confirmed by histological examination as well. In conclusion, the Cassia fistula fruit extract has significant hepatoprotective effect in our murine model.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
hepatic toxicology
Cassia fistula
bromobenzene
Megjelenés:Human & Experimental Toxicology. - 30 : 8 (2011), p. 1039-1044. -
További szerzők:Jalali, Mohammadtaha Jalali, Amir Mahdavinia, M. Salimi, Abobakr Juhász Béla (1978-) (kísérletes farmakológus) Tósaki Árpád (1958-) (kísérletes farmakológus, gyógyszerész) Gesztelyi Rudolf (1969-) (kísérletes farmakológus)
Pályázati támogatás:78223
OTKA
72315
OTKA
Internet cím:Szerző által megadott URL
DOI
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2.

001-es BibID:BIBFORM035753
Első szerző:Kalantari, Heybatullah
Cím:Protective effect of Cassia fistula fruit extract on bromobenzene-induced nephrotoxicity in mice / Kalantari, H., Jalali, M., Jalali, A., Salimi, A., Alhalvachi, F., Varga, B., Juhasz, B., Jakab, A., Kemeny-Beke, A., Gesztelyi, R., Tosaki, A., Zsuga, J.
Dátum:2011
ISSN:0960-3271
Megjegyzések:The efficacy of a crude hydro-alcoholic extract of Cassia fistula (golden shower tree) fruit to protect the kidney against bromobenzene-induced toxicity was studied. Negative control mice received normal saline; positive control mice were given 460 mg/kg of bromobenzene; Cassia fistula treated mice received 200, 400, 600 and 800 mg/kg of Cassia fistula fruit extract followed by 460 mg/kg bromobenzene (daily by oral gavage for 10 days). On the 11th day, the mice were sacrificed, blood samples were obtained to assess blood urea nitrogen (BUN) and creatinine levels, and kidneys were removed for histological examination. We found that bromobenzene induced significant nephrotoxicity reflected by an increase in levels of BUN and creatinine that was dose dependently prevented by the Cassia fistula fruit extract. The nephroprotective effect of the Cassia fistula fruit extract was confirmed by the histological examination of the kidneys. To the best of our knowledge, this is the first study to demonstrate the protective effect of Cassia fistula in nephrotoxicity.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Human & Experimental Toxicology. - 30 : 10 (2011), p. 1710-1715. -
További szerzők:Jalali, Mohammadtaha Jalali, Amir Salimi, Abobakr Alhalvachi, Foad Varga Balázs (1984-) (kísérletes farmakológus) Juhász Béla (1978-) (kísérletes farmakológus) Jakab Anita Kemény-Beke Ádám (1968-2021) (szemész) Gesztelyi Rudolf (1969-) (kísérletes farmakológus) Tósaki Árpád (1958-) (kísérletes farmakológus, gyógyszerész) Zsuga Judit (1973-) (neurológus, pszichoterapeuta, egészségügyi szakmanager)
Pályázati támogatás:78223
OTKA
72315
OTKA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
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