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001-es BibID:BIBFORM041164
035-os BibID:PMID:15242560
Első szerző:Tanguy, Stéphane
Cím:Preischemic selenium status as a major determinant of myocardial infarct size in vivo in rats / Stéphane Tanguy, Sandrine Morel, Corinne Berthonneche, Marie-Claire Toufektsian, Michel De Lorgeril, Véronique Ducros, Arpad Tosaki, Joel De Leiris, François Boucher
Dátum:2004
ISSN:1523-0864
Megjegyzések:Prospective epidemiological studies have shown that the incidence of numerous cardiovascular pathologies is correlated with body selenium status. However, it remains unclear whether selenium status also influences the outcome of myocardial infarction. The aim of the present study was to test whether dietary selenium intake affects myocardial necrosis induced by transient regional ischemia in vivo in rats. For this purpose, male Wistar rats received either a high-selenium (High-Se: 1.5 mg of Se/kg) or a low-selenium (Low-Se: 0.05 mg of Se/kg) diet for 10 weeks. Animals were subjected to 30 min of myocardial ischemia induced by coronary artery ligation followed by 60 min of reperfusion. Pre- and postischemic blood samples were collected for glutathione (GSH and GSSG) determination and for glutathione peroxidase (GSH-Px) assessment. Our results show that high-selenium intake reduces myocardial infarct size (High-Se: 25.16 +/- 1.19% versus Low-Se: 36.51 +/- 4.14%, p < 0.05), preserves postischemic GSH/GSSG ratio (High-Se: 1.37 +/- 0.37 versus Low-Se: 0.47 +/- 0.10, p < 0.05), increases plasma GSH-Px activity, and improves postischemic mean arterial pressure. In conclusion, preischemic body selenium status is a major determinant of the outcome of myocardial ischemia in vivo in rats probably because it influences the cellular redox status.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Antioxidants & Redox Signaling 6 : 4 (2004), p. 792-796. -
További szerzők:Morel, Sandrine Berthonneche, Corinne Toufektsian, Marie-Claire Lorgeril, Michel de Ducros, Véronique Tósaki Árpád (1958-) (kísérletes farmakológus, gyógyszerész) de Leiris, Joel Boucher, Francois
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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