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001-es BibID:BIBFORM010623
Első szerző:Boms, Neta
Cím:Effect of smoking cessation on visually evoked cerebral blood flow response in healthy volunteers / Neta Boms, Yaniv Yonai, Sandor Molnar, Bernhard Rosengarten, Natan M. Bornstein, Laszlo Csiba, Laszlo Olah
Dátum:2010
ISSN:1018-1172 (Print)
Megjegyzések:In our previous study, impaired visually evoked flow velocity response was demonstrated in young chronic smokers. Our aim was to study whether impaired cerebrovascular reactivity is reversible 6?18 months after smoking cessation. Methods: Flow velocity changes, evoked by visual stimulus, were recorded in the posterior cerebral arteries in 15 smokers, 15 former smokers and 15 nonsmokers. The stimulation protocol consisted of 10 cycles with a resting phase of 20 s (baseline) and a stimulating phase of 40 s for each cycle. Relative changes of flow velocity were expressed in relation to baseline. Breath holding index, visual evoked potential and intima-media thickness were also examined. Results: Repeated measures ANOVA revealed marked difference in the flow velocity time courses between the 3 groups (p ! 0.01). The flow response was significantly worse in former smokers than in nonsmokers (p ! 0.002), however, no significant difference was found between former and current smokers (p = 0.0556). Conclusion: This is the first transcranial Doppler study demonstrating long-term impairment of visually evoked cerebrovascular response af-ter smoking cessation. These findings indicate that the impairment of neurovascular coupling caused by smoking is due to structural changes of the vessels, rather than acute effect of smoking.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Transcranial Doppler
Hemodynamics
Vasoreactivity
Neurovascular coupling
Visual stimulation
Cerebral blood flow
Smoking
Megjelenés:Journal of Vascular Research. - 47 : 3 (2010), p. 214-220. -
További szerzők:Yonai, Yaniv Molnár Sándor (1973-) (neurológus) Rosengarten, Bernhard Bornstein, Natan M. Csiba László (1952-) (neurológus, pszichiáter) Oláh László (1967-) (neurológus)
Pályázati támogatás:K 68864
OTKA
ETT 260/2009
EGYÉB
ETT 197-05/2010
EGYÉB
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