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1.

001-es BibID:BIBFORM010623
Első szerző:Boms, Neta
Cím:Effect of smoking cessation on visually evoked cerebral blood flow response in healthy volunteers / Neta Boms, Yaniv Yonai, Sandor Molnar, Bernhard Rosengarten, Natan M. Bornstein, Laszlo Csiba, Laszlo Olah
Dátum:2010
ISSN:1018-1172 (Print)
Megjegyzések:In our previous study, impaired visually evoked flow velocity response was demonstrated in young chronic smokers. Our aim was to study whether impaired cerebrovascular reactivity is reversible 6?18 months after smoking cessation. Methods: Flow velocity changes, evoked by visual stimulus, were recorded in the posterior cerebral arteries in 15 smokers, 15 former smokers and 15 nonsmokers. The stimulation protocol consisted of 10 cycles with a resting phase of 20 s (baseline) and a stimulating phase of 40 s for each cycle. Relative changes of flow velocity were expressed in relation to baseline. Breath holding index, visual evoked potential and intima-media thickness were also examined. Results: Repeated measures ANOVA revealed marked difference in the flow velocity time courses between the 3 groups (p ! 0.01). The flow response was significantly worse in former smokers than in nonsmokers (p ! 0.002), however, no significant difference was found between former and current smokers (p = 0.0556). Conclusion: This is the first transcranial Doppler study demonstrating long-term impairment of visually evoked cerebrovascular response af-ter smoking cessation. These findings indicate that the impairment of neurovascular coupling caused by smoking is due to structural changes of the vessels, rather than acute effect of smoking.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Transcranial Doppler
Hemodynamics
Vasoreactivity
Neurovascular coupling
Visual stimulation
Cerebral blood flow
Smoking
Megjelenés:Journal of Vascular Research. - 47 : 3 (2010), p. 214-220. -
További szerzők:Yonai, Yaniv Molnár Sándor (1973-) (neurológus) Rosengarten, Bernhard Bornstein, Natan M. Csiba László (1952-) (neurológus, pszichiáter) Oláh László (1967-) (neurológus)
Pályázati támogatás:K 68864
OTKA
ETT 260/2009
EGYÉB
ETT 197-05/2010
EGYÉB
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM007352
Első szerző:Oláh László (neurológus)
Cím:Visually evoked cerebral vasomotor response in smoking and non-smoking young adults, investigated byfunctional transcanial doppler / László Oláh, Yaron Raiter, Claudia Candale, Sándor Molnár, Bernhard Rosengarten, Natan M. Bornstein, László Csiba
Dátum:2008
Megjegyzések:Smoking has been known to cause endothelial dysfunction and is an important risk factor for ischemic stroke. In our study we investigated whether chronic cigarette smoking affects the cerebral blood flow velocity response to a physiological, visual stimulus. By using a visual cortex stimulation paradigm, the flow velocity response in the posterior cerebral arteries (PCA) was measured bilaterally, in 32 young healthy adults (16 smokers, 16 non-smokers). The stimulation protocol consisted of 10 cycles with a resting phase of 20 seconds and a stimulating phase of 40 seconds for each cycle. Besides functional transcranial Doppler (TCD), laboratory tests and measurement of intima-media-thickness (IMT) were also performed. Repeated measure ANOVA was used to detect differences in visually evoked relative flow velocity time courses between smokers and non-smokers. Repeated measure ANOVA revealed marked difference in the peak systolic flow velocity time courses between smokers and non-smokers (p<0.001). Maximum percent change of visually evoked flow velocity after visual stimulation was 19?4% and 30?3% in smokers and non-smokers, respectively (p<0.0001). IMT values did not indicate atherosclerosis in young smokers. Infectious disease and hyperlipidaemia were also ruled out by measurement of sensitive Creactive protein and serum lipids. This is the first functional TCD study demonstrating impaired visually evoked flow velocity response caused by chronic cigarette smoking in otherwise healthy, young subjects. The impaired cerebral vasodilatory mechanism together with atherosclerosis may influence stroke occurrence and outcome in chronic smokers.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Nicotine Tobacco Research. - 10 : 2 (2008), p. 353-358. -
További szerzők:Raiter, Yaron Candale, Claudia Molnár Sándor (1973-) (neurológus) Rosengarten, Bernhard Bornstein, Natan M. Csiba László (1952-) (neurológus, pszichiáter)
Internet cím:elektronikus változat
DOI
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3.

001-es BibID:BIBFORM013718
Első szerző:Yonai, Yaniv
Cím:Acetazolamide-induced vasodilation does not inhibit the visually evoked flow response / Yaniv Yonai, Neta Boms, Sandor Molnar, Bernhard Rosengarten, Natan M. Bornstein, Laszlo Csiba, Laszlo Olah
Dátum:2010
ISSN:0271-678X
Megjegyzések:Different methods are used to assess the vasodilator ability of cerebral blood vessels; however, the exact mechanism of cerebral vasodilation, induced by different stimuli, is not entirely known. Our aim was to investigate whether the potent vasodilator agent, acetazolamide (AZ), inhibits the neurovascular coupling, which also requires vasodilation. Therefore, visually evoked flow parameters were examined by transcranial Doppler in ten healthy subjects before and after AZ administration. Pulsatility index and peak systolic flow velocity changes, evoked by visual stimulus, were recorded in the posterior cerebral arteries before and after intravenous administration of 15 mg/kg AZ. Repeated-measures ANOVA did not show significant group main effect between the visually evoked relative flow velocity time courses before and after AZ provocation (P=0.43). Visual stimulation induced significant increase of relative flow velocity and decrease of pulsatility index not only before but also at the maximal effect of AZ. These results suggest that maximal cerebral vasodilation cannot be determined by the clinically accepted dose of AZ (15 mg/kg) and prove that neurovascular coupling remains preserved despite AZ-induced vasodilation. Our observation indicates independent regulation of vasodilation during neurovascular coupling, allowing the adaptation of cerebral blood flow according to neuronal activity even if other processes require significant vasodilation.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Cerebral Blood Flow and Metabolism. - 30 : 3 (2010), p. 516-521. -
További szerzők:Boms, Neta Molnár Sándor (1973-) (neurológus) Rosengarten, Bernhard Bornstein, Natan M. Csiba László (1952-) (neurológus, pszichiáter) Oláh László (1967-) (neurológus)
Pályázati támogatás:0271-678x/10
Egyéb
ETT 260/2009
Egyéb
ETT 197-05/2010
Egyéb
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:
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