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001-es BibID:BIBFORM029437
Első szerző:Ujhelyi Bernadett (szemész)
Cím:Graves' orbitopathy results in profound changes in tear composition : a study of Plasminogen activator inhibitor-1 (PAI-1) and seven cytokines / Ujhelyi Bernadett, Gogolak Peter, Erdei Annamaria, Nagy Valeria, Balazs Erzsebet, Rajnavolgyi Eva, Berta Andras, Nagy Endre V.
Dátum:2012
ISSN:1050-7256
Megjegyzések:Secretion of cytokines and display of cytokine receptors have been reported in the orbital connective tissue in Graves' orbitopathy (GO). Lacrimal glands are putative autoimmune targets, and changes in tear film and ocular surface have also been described. Our aim was to characterize the cytokine profile of tears in Graves' patients with (GO) and without orbitopathy (GD).Methods: Tear samples were collected from 54 eyes of GO patients (age 43.4 ?15.2 years), 18 eyes of GD patients (age 46.8?11.7 years), and 24 control eyes (age 38.6?13.8 years). Patients underwent ophthalmological examination including Clinical Activity Score (CAS). The level of interleukin (IL)-1beta, IL-6, IL-13, IL-17A, IL-18, Tumor Necrosis Factor-alfa and RANTES (Regulated upon Activation, Normal T-cell Expressed, and Secreted) as well as Plasminogen activator inhibitor-1 (PAI-1) were measured by multiplex bead array and release values were calculated. Results: The release of IL-1beta, IL-6, IL-13, IL-17A, IL-18, TNF-alfa and RANTES were significantly higher in GO patients compared to controls (p<0.05). There was a 2.5-fold increase of IL-6 release. No significant differences were found in cytokine release between the GO and GD groups. In the GO group, significant positive correlation was found between CAS and the release of IL-6 and PAI-1 into tears (r=0.27, p<0.05 and r=0.24, p<0.05, respectively). PAI-1 release was significantly higher in GO than in GD patients, and was increased in both the GD and GO groups compared to controls. Conclusions: Impaired cytokine balance has been observed in tears of GO patients. Secretion of IL-6 into tears might be a useful indicator of disease activity in GO.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Endokrin orbitopathia
könny
citokin
PAI-1
immunológiai aktivitás
Megjelenés:Thyroid. - 22 : 4 (2012), p. 407-414. -
További szerzők:Gogolák Péter (1968-) (biológus, immunológus) Erdei Annamária (1976-) (belgyógyász) Nagy Valéria (1962-) (szemész) Balázs Erzsébet (1952-) (szemész) Rajnavölgyi Éva (1950-) (immunológus) Berta András (1955-) (szemész, gyermekszemész) Nagy Endre V. (1957-) (belgyógyász, endokrinológus)
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