CCL

Összesen 2 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM063542
035-os BibID:(cikkazonosító)e0153186 (WOS)000374131200058 (Scopus)84963717840
Első szerző:Pásztor Dorottya (szemész)
Cím:Tear Mediators in Corneal Ectatic Disorders / Pásztor Dorottya, Kolozsvári Bence Lajos, Csutak Adrienne, Berta András, Hassan Ziad, Ujhelyi Bernadett, Gogolák Péter, Fodor Mariann
Dátum:2016
ISSN:1932-6203
Megjegyzések:Purpose To compare the concentrations of 11 tear mediators in order to reveal the biochemical difference between pellucid marginal degeneration (PMD) and keratoconus (KC).MethodsWe have designed a cross-sectional study in which patients with corneal ectasia based on slit-lamp biomicroscopy and Pentacam HR (keratometry values (K1, K2, Kmax), astigmatism, minimal radius of curvature (Rmin), corneal thickness (Apex and Min), indices (surfacevariation, vertical asymmetry, keratoconus, central keratoconus, height asymmetry and decentration)) were enrolled. Eyes of keratoconic patients were similar to the PMD patients in age and severity (K2, Kmax and Rmin). Non-stimulated tear samples were collected from nine eyes of seven PMD patients, 55 eyes of 55 KC patients and 24 eyes of 24 healthy controls. The mediators' (interleukin -6, -10, chemokine ligand 5, -8, -10, matrix metalloproteinase (MMP) -9, -13, tissue inhibitor of metalloproteinases (TIMP)-1, tissue plasminogen activator, plasminogen activator inhibitor, nerve growth factor) concentrations were measured using Cytometric Bead Array.ResultsMMP-9 was the only mediator which presented relevant variances between the two patient groups (p = 0.005). The ratios of MMP-9 and TIMP-1 were 2.45, 0.40 and 0.23 in PMD, KC and the controls, respectively.ConclusionAs far as we are aware, this is the first study that aims to reveal the biochemical differences between PMD and KC. Further studies of biomarkers to investigate the precise role of these mediators need to be defined, and it is important to confirm the observed changes in a larger study to gain further insights into the molecular alterations in PMD.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Plos One. - 11 : 4 (2016), p. 1-14. -
További szerzők:Kolozsvári Bence Lajos (1977-) (szemész) Csutak Adrienne (1971-) (szemész) Berta András (1955-) (szemész, gyermekszemész) Hassan, Ziad (1962-) (szemész) Ujhelyi Bernadett (1981-) (szemész) Gogolák Péter (1968-) (biológus, immunológus) Fodor Mariann (1975-) (szemész)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM061808
Első szerző:Pásztor Dorottya (szemész)
Cím:Scheimpflug Imaging Parameters Associated with Tear Mediators and Bronchial Asthma in Keratoconus / Dorottya Pásztor, Bence Lajos Kolozsvári, Adrienne Csutak, András Berta, Ziad Hassan, Beáta Andrea Kettesy, Péter Gogolák, Mariann Fodor
Dátum:2016
Megjegyzések:To determine associations between mediators in tears in the whole spectrum of keratoconus (KC); to explore connectionsbetween mediators and Scheimpflug parameters; to examine correlations between Scheimpflug parameters and bronchial asthma.Methods. Tear samples were collected from 69 patients and 19 controls. Concentrations of mediators?IL-6, -10; CXCL8, CCL5;MMP-9, -13; TIMP-1; t-PA, PAI-1?weremeasured by Cytometric Bead Array.Measured Pentacamparameters include keratometryvalues (??1, ??2, ??max), corneal thickness (Pachy Pupil, Apex, Min), and elevations and indices (including Belin-Ambr?osiodeviation (BAD-D)). Results.Anumber of significant positive associationswere observed between pairs ofmediator concentrations.Significant positive correlations were found between BAD-D and CXCL8/MMP-9 and ??2 and MMP-9. Significant negativeassociations were explored between Pachy Min and CXCL8/t-PA. Significant associations were found between pairs of mediators(IL-6 and CXCL8; CCL5 and CXCL8/MMP-9; TIMP-1 andMMP-9/-13/t-PA; t-PAand CXCL8/CCL5/PAI-1) and the severity of KC.Significant positive correlation between asthma and the severity ofKCwas explored. Conclusion.Cooperation of differentmediatorsin tears all taking part in the complex pathomechanism of keratoconus was revealed. Our research verifies that inflammation playsa crucial role in the pathogenesis of KC. Additionally this study confirms the effect of bronchial asthma on keratoconus.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Scheimpflug
Bronchial Asthma
Megjelenés:Journal of Ophthalmology 2016 : 9392640 (2016), p. 1-7. -
További szerzők:Kolozsvári Bence Lajos (1977-) (szemész) Csutak Adrienne (1971-) (szemész) Berta András (1955-) (szemész, gyermekszemész) Hassan, Ziad (1962-) (szemész) Kettesy Beáta (1974-) (szemész) Gogolák Péter (1968-) (biológus, immunológus) Fodor Mariann (1975-) (szemész)
Internet cím:Szerző által megadott URL
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1