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001-es BibID:	BIBFORM005613
Első szerző:	Réthi Bence (biológus, immunológus)
Cím:	Priming of T cells to Fas-mediated proliferative signals by interleukin-7 / Bence Rethi, Nancy Vivar, Stefano Sammicheli, Caroline Fluur, Nicolas Ruffin, Ann Atlas, Eva Rajnavolgyi, Francesca Chiodi
Dátum:	2008
Megjegyzések:	T-cell depletion associated with HIV infection or cytoreductive therapies triggers potential T-cell regenerative mechanisms such as peripheral T-lymphocyte expansion to weak antigenic stimuli and the increased availability of interleukin-7 (IL-7), a cytokine with potent antiapoptotic and proliferative activities. Deleterious mechanisms also associated with lymphopenia, such as increased Fas expression and apoptosis of T cell, however, may result in opposing effects. In this study, we show that Fas molecules, primarily associated with T-cell depletion in lymphopenic settings, may also contribute to compensatory T-cell expansion through transmitting costimulatory signals to suboptimally activated T cells. Proliferation of T lymphocytes in response to concomitant Fas and T-cell receptor (TCR) triggering was shown to be increased in HIV-infected individuals compared with noninfected controls. As IL-7 levels are often elevated in lymphopenic individuals in association with increased Fas expression, we analyzed whether IL-7 Would influence Fas-mediated proliferative signals in T cells. We show that IL-7 is able to increase the efficacy of Fas to induce proliferation of suboptimally activated T cells. Thus, high IL-7 levels associated with lymphopenic conditions may simultaneously induce sensitivity to Fas-mediated apoptosis in nonactivated T cells and increase Fas-induced costimulatory signals in T cells recognizing low-affinity antigens.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Virus TYPE-1 Infection HIV-1 Infection Homeostatic Proliferation Receptro Expression Sooty Mangabeys Down-regulation Up-regulation Activation Apoptosis
Megjelenés:	Blood. - 112 : 4 (2008), p. 1195-1204. -
További szerzők:	Vivar, Nancy Sammicheli, Stefano Fluur, Caroline Ruffin, Nicolas Atlas, Ann Rajnavölgyi Éva (1950-) (immunológus) Chiodi, Francesca
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001-es BibID:	BIBFORM005817
Első szerző:	Titanji, Kehmia
Cím:	Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infection / Kehmia Titanji, Stefano Sammicheli, Angelo De Milito, Paola Mantegani, Claudio Fortis, Louise Berg, Klas Karre, Giovanna Travi, Chiara Tassandin, Lucia Lopalco, Bence Rethi, Giuseppe Tambussi, Francesca Chiodi
Dátum:	2008
Megjegyzések:	Human natural killer (NK) (CD3(-) CD56(+)) cells can be divided into two functionally distinct subsets, CD3(-) CD56(dim) and CD3(-) CD56(bright). We analysed the distribution of NK cell subsets in primary and chronic human immunodeficiency virus-1 (HIV-1) infection, to determine if HIV infection stage may influence the subset distribution. In primary infection, contrary to chronic infection, the CD3(-) CD56(dim) subset was expanded compared to healthy controls. We also studied the effect of antiretroviral therapy administered early in infection and found that NK cell subset distribution was partially restored after 6 months of antiretroviral therapy in primary infection, but not normalized. Recently, NK cells have been divided into CD27(-) and CD27(+) subsets with different migratory and functional capacity and CD27-mediated NK cell activation has been described in mice. We therefore investigated whether CD27 and/or CD70 (CD27 ligand) expression on NK cells, and thus the distribution of these novel NK subsets, was altered in HIV-1-infected patients. We found up-regulated expression of both CD27 and CD70 on NK cells of patients, resulting in higher proportions of CD27(high) and CD70(high) NK cells, and this phenomenon was more pronounced in chronic infection. Experiments conducted in vitro suggest that the high interleukin-7 levels found during HIV-1 infection may participate in up-regulation of CD70 on NK cell subsets. Imbalance of NK cell subsets and up-regulated expression of CD27 and CD70 initiated early in HIV-1 infection may indicate NK cell activation and intrinsic defects initiated by HIV-1 to disarm the innate immune response to the virus.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban HIV-1 CD27 CD70 NK cells immune activation antiretroviral therapy
Megjelenés:	Immunology. - 123 : 2 (2008), p. 164-170. -
További szerzők:	Sammicheli, Stefano De Milito, Angelo Mantegani, Paola Fortis, Claudio Berg, Louise Karre, Klas Travi, Giovanna Tassandin, Chiara Lopalco, Lucia Réthi Bence (1973-) (biológus, immunológus) Tambussi, Giuseppe Chiodi, Francesca
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