Találati lista | Tudóstér

001-es BibID:	BIBFORM005613
Első szerző:	Réthi Bence (biológus, immunológus)
Cím:	Priming of T cells to Fas-mediated proliferative signals by interleukin-7 / Bence Rethi, Nancy Vivar, Stefano Sammicheli, Caroline Fluur, Nicolas Ruffin, Ann Atlas, Eva Rajnavolgyi, Francesca Chiodi
Dátum:	2008
Megjegyzések:	T-cell depletion associated with HIV infection or cytoreductive therapies triggers potential T-cell regenerative mechanisms such as peripheral T-lymphocyte expansion to weak antigenic stimuli and the increased availability of interleukin-7 (IL-7), a cytokine with potent antiapoptotic and proliferative activities. Deleterious mechanisms also associated with lymphopenia, such as increased Fas expression and apoptosis of T cell, however, may result in opposing effects. In this study, we show that Fas molecules, primarily associated with T-cell depletion in lymphopenic settings, may also contribute to compensatory T-cell expansion through transmitting costimulatory signals to suboptimally activated T cells. Proliferation of T lymphocytes in response to concomitant Fas and T-cell receptor (TCR) triggering was shown to be increased in HIV-infected individuals compared with noninfected controls. As IL-7 levels are often elevated in lymphopenic individuals in association with increased Fas expression, we analyzed whether IL-7 Would influence Fas-mediated proliferative signals in T cells. We show that IL-7 is able to increase the efficacy of Fas to induce proliferation of suboptimally activated T cells. Thus, high IL-7 levels associated with lymphopenic conditions may simultaneously induce sensitivity to Fas-mediated apoptosis in nonactivated T cells and increase Fas-induced costimulatory signals in T cells recognizing low-affinity antigens.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Virus TYPE-1 Infection HIV-1 Infection Homeostatic Proliferation Receptro Expression Sooty Mangabeys Down-regulation Up-regulation Activation Apoptosis
Megjelenés:	Blood. - 112 : 4 (2008), p. 1195-1204. -
További szerzők:	Vivar, Nancy Sammicheli, Stefano Fluur, Caroline Ruffin, Nicolas Atlas, Ann Rajnavölgyi Éva (1950-) (immunológus) Chiodi, Francesca
Internet cím:	elektronikus változat DOI elektronikus változat
Borító:
Saját polcon: