CCL

Összesen 1 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM065587
Első szerző:Rajnavölgyi Éva (immunológus)
Cím:IL-7 withdrawal induces a stress pathway activating p38 and Jun N-terminal kinases / Eva Rajnavolgyi, Naima Benbernou, Bence Rethi, Della Reynolds, Howard A. Young, Maria Magocsi, Kathrin Muegge, Scott K. Durum
Dátum:2002
ISSN:0898-6568
Megjegyzések:IL-7 delivers survival signals to cells at an early stage in lymphoid development. In the absence of IL-7, pro-T cells undergo programmed cell death, which has previously been associated with a decline in Bcl-2 and translocation of Bax from cytosol to mitochondria. A new, earlier feature of IL-7 withdrawal was identified using an IL-7-dependent thymocyte line. We observed that withdrawal of IL-7 induced increased expression of jun and fos family member genes including c-jun, junB, junD, c-fos and fra2. This transient response peaked 3-4 h after IL-7 was withdrawn and resulted in increased DNA-binding activity of AP-1 and in a change in the composition of the Jun/Fos family dimers shown by electrophoretic mobility shift and supershift assays. Induction of jun and fos genes and the increased DNA-binding activity of AP-1 were attributable to the phosphorylation-induced activation of the stress kinases p38 and JNK and were blocked by the chemical kinase inhibitors SB203580 and SB202190. The stress response contributed to cell death following IL-7 withdrawal as shown by blocking the activity of the stress (MAP) kinases or by blocking the production of c-Jun and c-Fos using antisense oligonucleotides.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Apoptosis
Cell death
Interleukin-7
jun
fos
MAP kinase
Lymphocyte
Stress
Megjelenés:Cellular Signalling 14 : 9 (2002), p. 761-769. -
További szerzők:Benbernou, Naima Réthi Bence (1973-) (biológus, immunológus) Reynolds, Della Young, Howard A. Magócsi Mária Muegge, Kathrin Durum, Scott K.
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1