Találati lista | Tudóstér

001-es BibID:	BIBFORM046581
035-os BibID:	PMID:23638129
Első szerző:	Gericke, Janine (táplálkozástudományi szakember)
Cím:	Regulation of Retinoid-Mediated Signaling Involved in Skin Homeostasis by RAR and RXR Agonists/Antagonists in Mouse Skin / Janine Gericke, Jan Ittensohn, Johanna Mihály, Susana Álvarez, Rosana Álvarez, Dániel Törőcsik, Ángel R. de Lera, Ralph Rühl
Dátum:	2013
ISSN:	1932-6203
Megjegyzések:	Endogenous retinoids like all-trans retinoic acid (ATRA) play important roles in skin homeostasis and skin-based immuneresponses. Moreover, retinoid signaling was found to be dysregulated in various skin diseases. The present study usedtopical application of selective agonists and antagonists for retinoic acid receptors (RARs) a and c and retinoid-X receptors(RXRs) for two weeks on mouse skin in order to determine the role of retinoid receptor subtypes in the gene regulation inskin. We observed pronounced epidermal hyperproliferation upon application of ATRA and synthetic agonists for RARc andRXR. ATRA and the RARc agonist further increased retinoid target gene expression (Rbp1, Crabp2, Krt4, Cyp26a1, Cyp26b1)and the chemokines Ccl17 and Ccl22. In contrast, a RARa agonist strongly decreased the expression of ATRA-synthesisenzymes, of retinoid target genes, markers of skin homeostasis, and various cytokines in the skin, thereby markedlyresembling the expression profile induced by RXR and RAR antagonists. Our results indicate that RARa and RARc subtypespossess different roles in the skin and may be of relevance for the auto-regulation of endogenous retinoid signaling in skin.We suggest that dysregulated retinoid signaling in the skin mediated by RXR, RARa and/or RARc may promote skin-basedinflammation and dysregulation of skin barrier properties
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban ATRA Skin Homeostasis RARs
Megjelenés:	Plos One. - 8 : 4 (2013), p. e62643. -
További szerzők:	Ittensohn, Jan Mihály Johanna (1982-) (biológus, vegyész) Álvarez, Susana Álvarez, Rosana Töröcsik Dániel (1979-) (bőrgyógyász) de Lera, Ángel R. Rühl, Ralph (1969-) (vegyész)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM074734
035-os BibID:	(cikkazonosító)e0198323 (WOS)000435802500016 (Scopus)85048863741
Első szerző:	Töröcsik Dániel (bőrgyógyász)
Cím:	Genome wide analysis of TLR1/2- and TLR4-activated SZ95 sebocytes reveals a complex immune-competence and identifies serum amyloid A as a marker for activated sebaceous glands / Dániel Törőcsik, Dóra Kovács, Szilárd Póliska, Zita Szentkereszty-Kovács, Marianna Lovászi, Katalin Hegyi, Andrea Szegedi, Christos C. Zouboulis, Mona Ståhle
Dátum:	2018
ISSN:	1932-6203
Megjegyzések:	Toll-like receptors (TLR) 2 and 4 are active in sebaceous glands and play a central role in the development of acne. Still, there is only limited knowledge on their effect on sebocytes. In this work we performed global gene expression profile analysis with functional clustering of the differentially regulated genes of TLR1/2 (PAM3CSK4)- and TLR4 (lipopolysaccharide [LPS])-activated SZ95 sebocytes. Both TLR1/2- and 4-activation promoted inflammation in a similar manner already at an early time-point (6 hours), regulating genes involved in inflammation, wound healing and chemotaxis reflecting a more complex cytokine and chemokine regulation than previously known. Importantly, lipid metabolism, the primary feature of sebocytes, was affected at the level of gene expression only at a later time point (24 hours) indicating that sebocytes prioritize to exert a pro-inflammatory phenotype when confronted with a danger signal. Supporting the biological relevance of our results, a meta-analysis revealed that the genes showing the strongest up-regulation were also found up-regulated in acne. Of these genes, serum amyloid A 1/2 (SAA1/2) was confirmed to be a suitable protein marker for in vivo activated sebocytes, underlining their immune-competence, which is structurally defined within sebaceous glands of acne and rosacea skin samples. Altogether our findings demonstrate that sebocytes are not only positioned at the end point of inflammation but are actively involved in shaping the inflammatory response with putative diagnostic and therapeutic relevance.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Acne Gene expression Sebaceous glands Inflammation Gene regulation Inflammatory diseases Immune response Lipid metabolism
Megjelenés:	Plos One. - 13 : 6 (2018), p. 1-20. -
További szerzők:	Kovács Dóra (1988-) (Biológus) Póliska Szilárd (1978-) (biológus) Szentkereszty-Kovács Zita (1988-) (orvos) Lovászi Marianna (1986-) (biológus) Dull Katalin (1983-) (molekuláris biológus, genetikus) Szegedi Andrea (1964-) (bőrgyógyász) Zouboulis, Christos C. (1960-) (bőrgyógyász) Ståhle, Mona
Pályázati támogatás:	GINOP-2.3.2-15-2016-00005 GINOP GINOP-2.3.2-15-2016-00050 GINOP EFOP-3.6.1-16-2016-00022 EFOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: