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001-es BibID:BIBFORM105072
035-os BibID:(cikkazonosító)1029818 (Scopus)85142633292 (WOS)000889955400001 (PubMed)36439142
Első szerző:Zouboulis, Christos C. (bőrgyógyász)
Cím:Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations / Zouboulis Christos C., Coenye Tom, He Li, Kabashima Kenji, Kobayashi Tetsuro, Niemann Catherin, Nomura Takashi, Oláh Attila, Picardo Mauro, Quist Sven R., Sasano Hironobu, Schneider Marlon R., Törőcsik Daniel, Wong Sunny Y.
Dátum:2022
ISSN:1664-3224
Megjegyzések:This review presents several aspects of the innovative concept of sebaceous immunobiology, which summarizes the numerous activities of the sebaceous gland including its classical physiological and pathophysiological tasks, namely sebum production and the development of seborrhea and acne. Sebaceous lipids, which represent 90% of the skin surface lipids in adolescents and adults, are markedly involved in the skin barrier function and perifollicular and dermal innate immune processes, leading to inflammatory skin diseases. Innovative experimental techniques using stem cell and sebocyte models have clarified the roles of distinct stem cells in sebaceous gland physiology and sebocyte function control mechanisms. The sebaceous gland represents an integral part of the pilosebaceous unit and its status is connected to hair follicle morphogenesis. Interestingly, professional inflammatory cells contribute to sebocyte differentiation and homeostasis, whereas the regulation of sebaceous gland function by immune cells is antigen-independent. Inflammation is involved in the very earliest differentiation changes of the pilosebaceous unit in acne. Sebocytes behave as potent immune regulators, integrating into the innate immune responses of the skin. Expressing inflammatory mediators, sebocytes also contribute to the polarization of cutaneous T cells towards the Th17 phenotype. In addition, the immune response of the perifollicular infiltrate depends on factors produced by the sebaceous glands, mostly sebaceous lipids. Human sebocytes in vitro express functional pattern recognition receptors, which are likely to interact with bacteria in acne pathogenesis. Sex steroids, peroxisome proliferatoractivated receptor ligands, neuropeptides, endocannabinoids and a selective apoptotic process contribute to a complex regulation of sebocyte-induced immunological reaction in numerous acquired and congenital skin diseases, including hair diseases and atopic dermatitis.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
sebaceous gland
sebocyte
hair follicle
developmental biology
stem cells
immunology
inflammation
sebaceous gland disease
Megjelenés:Frontiers in Immunology. - 13 (2022), p. 1029818. -
További szerzők:Coenye, Tom He, Li Kabashima, Kenji Kobayashi, Tetsuro Niemann, Catherin Nomura, Takashi Oláh Attila (1984-) (élettanász) Picardo, Mauro Quist, Sven R. Sasano, Hironobu Schneider, Marlon R. Töröcsik Dániel (1979-) (bőrgyógyász) Wong, Sunny Y.
Pályázati támogatás:134235
OTKA
132296
OTKA
Bolyai János Kutatási Ösztöndíj
MTA
ÚNKP-22-5-DE-427
Egyéb
NIH R01AR065409
Egyéb
NIH R01AR080654
Egyéb
TLC-21-161-01-TLC
Egyéb
20H03705
Egyéb
20K21534
Egyéb
JP21gm6510005
Egyéb
LEO Foundation Grant
Egyéb
Takeda Science Foundation
Egyéb
73111208
Egyéb
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DOI
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001-es BibID:BIBFORM065809
Első szerző:Zouboulis, Christos C. (bőrgyógyász)
Cím:Beyond acne : current aspects of sebaceous gland biology and function / Christos C. Zouboulis, Mauro Picardo, Qiang Ju, Ichiro Kurokawa, Dániel Törőcsik, Tamás Bíró, Marlon R. Schneider
Dátum:2016
Megjegyzések:The sebaceous gland is mostly found in association with a hair follicle. Its traditional function is the holocrine production of sebum, a complex mixture of lipids, cell debris, and other rather poorly characterized substances. Due to the gland central role in acne pathogenesis, early research had focused on its lipogenic activity. Less-studied aspects of the sebaceous gland, such as stem cell biology, the regulation of cellular differentiation by transcription factors, the significance of specific lipid fractions, the endocrine and specially the neuroendocrine role of the sebaceous gland, and its contribution to the innate immunity, the detoxification of the skin and skin aging have recently attracted the attention of researchers from different disciplines. Here, we summarize recent, multidisciplinary progress in sebaceous gland research and discuss how sebaceous gland research may stimulate the development of novel therapeutic strategies targeting specific molecular pathways of the pathogenesis of skin diseases.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Sebaceous gland
human
sebocyte
cells
sebaceous lineage
progenitor cells
sebaceous differentiation
ebum is characterized by specific lipid
lipidomics
cell function
neuropeptides
culture models
in vitro
ex vivo
proteom
secretom
Megjelenés:Reviews in Endocrine and Metabolic Disorders 17 : 3 (2016), p. 319-334. -
További szerzők:Picardo, Mauro Ju, Qiang Kurokawa, Ichiro Töröcsik Dániel (1979-) (bőrgyógyász) Bíró Tamás (1968-) (élettanász) Schneider, Marlon R.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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