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1.

001-es BibID:BIBFORM033343
Első szerző:Budd, Julian M. L.
Cím:Local lateral connectivity of inhibitory clutch cells in layer 4 of cat visual cortex (area 17) / Julian M. L. Budd, Zoltán F. Kisvárday
Dátum:2001
ISSN:0014-4819
Megjegyzések:To characterise spatially a major component of the anatomical basis of local lateral inhibition in layer 4 of cat visual cortex (area 17), we analysed the lateral distribution of neuronal somata postsynaptic to electrophysiologically characterised GABAergic clutch (basket) cell axons (CC1 and CC2). We report two main results. First, the clutch cell axons appear to show isotropic lateral connectivity near their cell body (less than 50 microm radius), but beyond this core region they show anisotropic lateral connectivity, preferring particular angular sectors around their cell body. Second, we estimated the probability of lateral connection for each axon arbor as a function of radial distance from the parent soma. We found that this radial function has a brief rising phase, to a peak at 30-45 microm, and a longer, exponential decaying phase, with a space constant of around 50 microm. The shape of the radial connection probability function suggests that most lateral inhibitory connections of clutch cells are formed with neurons in nearest-neighbour cortical columns. Taken together, the results suggest that these individual layer-4 clutch cell axons may inhibit all (isotropic) nearest-neighbour cortical columns with a relatively high probability of connection, but outside this core region may provide a type of anisotropic lateral inhibition of cortical columns with a radially decreasing probability of connection.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Experimental Brain Research. - 140 : 2 (2001), p. 245-250. -
További szerzők:Kisvárday Zoltán (1957-) (biológus, neurobiológus)
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2.

001-es BibID:BIBFORM033349
Első szerző:Buzás Péter
Cím:Functional topography of single cortical cells : an intracellular approach combined with optical imaging / Péter Buzás, Ulf T. Eysel, Zoltán F. Kisvárday
Dátum:1998
ISSN:1385-299X
Megjegyzések:Pyramidal cells mediating long-range corticocortical connections have been assumed to play an important role in visual perceptual mechanisms [C.D. Gilbert, Horizontal integration and cortical dynamics, Neuron 9 (1992) 1-13]. However, no information is available as yet on the specificity of individual pyramidal cells with respect to functional maps, e.g., orientation map. Here, we show a combination of techniques with which the functional topography of single pyramidal neurons can be explored in utmost detail. To this end, we used optical imaging of intrinsic signals followed by intracellular recording and staining with biocytin in vivo. The axonal and dendritic trees of the labelled neurons were reconstructed in three dimensions and aligned with corresponding functional orientation maps. The results indicate that, contrary to the sharp orientation tuning of neurons shown by the recorded spike activity, the efferent connections (axon terminal distribution) of the same pyramidal cells were found to terminate at a much broader range of orientations.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Brain Research Protocols. - 3 : 2 (1998), p. 199-208. -
További szerzők:Eysel, Ulf T. Kisvárday Zoltán (1957-) (biológus, neurobiológus)
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Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM065192
Első szerző:Karube, Fuyuki
Cím:Axon topography of layer 6 spiny cells to orientation map in the primary visual cortex of the cat (area 18) / Fuyuki Karube, Katalin Sári, Zoltán F. Kisvárday
Dátum:2017
ISSN:1863-2653 1863-2661
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Apical dendrite
Bouton overlap
Optical imaging
Pyramidal cell
3D reconstruction
Megjelenés:Brain Structure & Function 222 : 3 (2017). p. 1401-1426. -
További szerzők:Sári Katalin Kisvárday Zoltán (1957-) (biológus, neurobiológus)
Pályázati támogatás:FP7-2010-IST-FETPI 269921
FP7
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM033419
Első szerző:Kisvárday Zoltán (biológus, neurobiológus)
Cím:Synapses, axonal and dendritic patterns of GABA-immunoreactive neurons in human cerebral cortex / Z. F. Kisvárday, A. Gulyas, D. Beroukas, J. B. North, I. W. Chubb, P. Somogyi
Dátum:1990
ISSN:0006-8950
Megjegyzések:Gamma-aminobutyric acid (GABA) containing neurons were characterized in human association cortex by a combination of Golgi impregnation and immunohistochemistry. Neurons were Golgi impregnated, gold toned, drawn and then classified on the basis of their dendritic and axonal arborization in layers I-VI. An antiserum to GABA was used to determine which of the impregnated neurons were immunopositive. Twenty-four GABA-positive cells were Golgi impregnated: 7 were bitufted with their dendrites predominantly radially oriented, and 17 were multipolar stellate cells. Three of the multipolar cells with large somata in the deep layers showed dendritic patterns similar to previously described basket cells. Nine of the multipolar stellate cells in layers III-VI showed characteristics of 'neurogliaform' neurons (Ramón y Cajal, 1899). The somata and the dendritic field of these cells were spherical, with diameters of about 10-15 microns and 200 microns, respectively. Their dendrites were smooth and slightly beaded. The axon collaterals were densely distributed in and around the dendritic field, in a spherical area with a diameter of at least 300 microns. The thin axon collaterals had only occasional 'en passant' swellings. Contacts between the axons of neurogliaform cells and the distal dendrites of Golgi-impregnated pyramidal cells were observed. Electron microscopic immunocytochemistry revealed that GABA immunopositive nerve terminals formed symmetric synaptic contacts with somata, with GABA immunonegative and immunopositive dendritic shafts and with dendritic spines. The results show that GABAergic neurons are heterogeneous with respect to their dendritic and axonal patterns. In addition to the chandelier and basket cells, which have been shown in animal studies to contain GABA, other cell types, most prominently the neurogliaform cells, terminating on the distal parts of neurons, also contain GABA and may have a inhibitory function. Many of the GABAergic terminals make synapses on dendritic spines and shafts in the human cerebral cortex.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Brain. - 113 : 3 (1990), p. 793-812. -
További szerzők:Gulyas A. Beroukas, D. North, J. B. Chubb, I. W. Somogyi Péter
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Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM033390
035-os BibID:PMID:3007194 WOS:A1986A521100008
Első szerző:Kisvárday Zoltán (biológus, neurobiológus)
Cím:The relationship between GABA immunoreactivity and labelling by local uptake of [3H]GABA in the striate cortex of monkey / Z. F. Kisvárday, A. Cowey, A. J. Hodgson, P. Somogyi
Dátum:1986
ISSN:0014-4819
Megjegyzések:An antiserum to GABA was used in the macaque monkey to determine whether neurons that accumulate exogenously applied [3H]GABA in vivo are also immunoreactive for GABA. Following the injection of [3H]GABA into different laminae of striate cortex in two untreated animals and in one animal treated with amino-oxyacetic acid, selective accumulation of the labelled amino acid was demonstrated in perikarya by autoradiography. Radiographically labelled neurons (n, 519) and their unlabelled neighbours were tested in consecutive 0.5 micron thick sections by immunocytochemistry for GABA immunoreactivity. Injection of [3H]GABA did not increase the number of neurons showing GABA immunoreactivity. On the contrary many of the cells that accumulated [3H]GABA were immunonegative. These neurons were mostly located in layers IVC and VA following [3H]GABA injection into layers II-III, and in layers upper III and II following injection into layers V and VI. A comparison of the position of these neurons with known local projection patterns in the striate cortex of monkey suggests that GABA-immunonegative neurons may nevertheless become labelled by [3H]GABA if most of their local axon terminals fall within the injection site. The interlaminar projection of GABA-immunopositive neurons, which probably contain endogenous GABA, could be deduced from the position of the [3H]GABA injection site that leads to their autoradiographic labelling. Although the present study confirmed our previous results on the interlaminar connections of neurons that accumulate [3H]GABA, it demonstrated that [3H]GABA labelling alone may not be a sufficient criterion to assess the GABAergic nature of neurons in the striate cortex of monkey.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Experimental Brain Research. - 62 : 1 (1986), p. 89-98. -
További szerzők:Cowey, Alan Hodgson, Anthony J. Somogyi Péter
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM033389
035-os BibID:WOS:A1986G474600018
Első szerző:Kisvárday Zoltán (biológus, neurobiológus)
Cím:Synaptic targets of HRP-filled layer III pyramidal cells in the cat striate cortex / Z. F. Kisvárday, K. A. C. Martin, T. F. Freund, Zs. Maglóczky, D. Whitteridge, P. Somogyi
Dátum:1986
ISSN:0014-4819
Megjegyzések:There are numerous hypotheses for the role of the axon collaterals of pyramidal cells. Most hypotheses predict that pyramidal cells activate specific classes of postsynaptic cells. We have studied the postsynaptic targets of two layer III pyramidal cells, that were of special interest because of their clumped axon arborization near, and also 0.4-1.0 mm from the cell body, in register in both layers III and V. 191 terminations from four sites (layers III and V, both in the column of the cell and in distant clumps) were analysed by electron microscopy. Only one bouton contacted a cell body and that was immunoreactive for GABA. The major targets were dendritic spines (84 and 87%), and the remainder were dendritic shafts. Of these 13 were classed as pyramidal-like (P), 8 smooth cell-like (S) and three could not be classified. Four of five S types, but none of the seven P types tested were immunoreactive for GABA, supporting the fine structural classification. The putative inhibitory cells therefore formed not more than 5% of the postsynaptic targets, and their activation could only take place through the convergence of pyramidal cells onto a select population of GABA cells. The results show that the type of pyramidal cells with clumped axons studied here make contacts predominantly with other pyramidal cells. Thus the primary role of both the intra and intercolumnar collateral systems is the activation of other excitatory cells.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Experimental Brain Research. - 64 (1986), p. 541-552. -
További szerzők:Martin, Kevan A. C. Freund Tamás F. Maglóczky Zsófia Whitteridge, David Somogyi Péter
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7.

001-es BibID:BIBFORM033435
035-os BibID:WOS:A1992HZ70900018
Első szerző:Kisvárday Zoltán (biológus, neurobiológus)
Cím:GABAergic networks of basket cells in the visual cortex / Zoltán F. Kisvárday
Dátum:1992
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Progress in Brain Research. - 90 (1992), p. 385-405. -
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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8.

001-es BibID:BIBFORM033364
Első szerző:Kisvárday Zoltán (biológus, neurobiológus)
Cím:Direct and indirect retinal input into degenerated dorsal lateral geniculate nucleus after striate cortical removal in monkey : implications for residual vision / Kisvárday Zoltán F., Cowey Alan, Stoerig Petra, Somogyi Péter
Dátum:1991
ISSN:0014-4819
Megjegyzések:We removed the striate cortex of one cerebral hemisphere in a macaque monkey, causing almost total retrograde degeneration of the corresponding dorsal lateral geniculate nucleus (dLGN) and extensive transneuronal degeneration of ganglion cells in the corresponding hemi-retina of each eye. The rare surviving geniculate projection neurons were retrogradely labelled by horseradish peroxidase (HRP) from extra-striate cortex and retinogeniculate terminals were labelled by an intraocular injection of HRP. Retinal terminals in the degenerated dLGN made synaptic contact exclusively with the dendrites of interneurons immunopositive for gamma-aminobutyric acid (GABA) in both parvocellular and magnocellular regions of dLGN. As well as being post-synaptic to retinal terminals these vesicle-containing dendrites were pre- and postsynaptic to other similar dendrites, and presynaptic to relay cells. Surviving labelled projection neurons received retinal input indirectly, via both the GABA-immunopositive interneurons and GABA-immunonegative terminals characteristic of those from the superior colliculus. In the degenerated, as opposed to the normal dLGN, about 20% of retinal terminals were GABA-immunopositive and GABA-immunoreactivity was prominently elevated in the ganglion and amacrine cell layers of the degenerated half of the retina. The optic nerve also contained numerous GABA-immunopositive axons but very few such axons were found in a normal optic nerve processed in identical manner. The surviving pathways from the retina must underlie the visual abilities that survive striate cortical removal in monkeys and human patients and may involve the degenerated dLGN as well as the mid-brain.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Experimental Brain Research. - 86 : 2 (1991), p. 271-292. -
További szerzők:Cowey, Alan Stoerig, Petra Somogyi Péter
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9.

001-es BibID:BIBFORM033400
035-os BibID:PMID:6171325
Első szerző:Somogyi Péter
Cím:Selectivity of neuronal [3H]GABA accumulation in the visual cortex as revealed by Golgi staining of the labeled neurons / Péter Somogyi, Tamás F. Freund, Norbert Halász, Zoltán F. Kisvárday
Dátum:1981
ISSN:0006-8993
Megjegyzések:[3H]GABA was injected into the visual cortex of rats in vivo. The labeled amino acid was demonstrated by autoradiography using semithin sections of Golgi material. Selective accumulation was seen in the perikarya of Golgi-stained, gold-toned, aspinous stellate neurons. Spine-laden pyramidal-like cells did not show labeling. This method gives direct information about the dendritic arborization of a neuron, and its putative transmitter, and allows the identification of its synaptic connections.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Brain Research. - 225 : 2 (1981), p. 431-436. -
További szerzők:Freund Tamás F. Halász Norbert Kisvárday Zoltán (1957-) (biológus, neurobiológus)
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10.

001-es BibID:BIBFORM033394
035-os BibID:PMID:6200348 WOS:A1984SB66300009
Első szerző:Somogyi Péter
Cím:Characterization by Golgi impregnation of neurons that accumulate 3H-GABA in the visual cortex of monkey / P. Somogyi, Z. F. Kisvárday, T. F. Freund, A. Cowey
Dátum:1984
ISSN:0014-4819
Megjegyzések:3H-GABA was injected into restricted regions of visual areas 1 and 2 (cortical areas 17 and 18) on the lateral surface of the occipital lobe in monkeys. The injected tissue was processed for Golgi impregnation and gold toning. Sections containing Golgi-impregnated neurons were re-embedded, sectioned at 1 micron, and prepared for autoradiography to reveal neurones that had selectively accumulated 3H-GABA. Golgi-impregnated pyramidal, spiny stellate and aspiny nonpyramidal neurons were examined for 3H-GABA accumulation. Out of 47 aspiny non-pyramidal neurons 16 were labelled by 3H-GABA. The other cell types did not accumulate the amino acid. Twelve of the labelled neurons were drawn. Eight were bitufted neurons with their dendrites oriented predominantly radially, three were small multipolar neurons, and one could be reconstructed only partially. One neuron had a locally arborizing axon in layer III. Two bitufted, Golgi-impregnated neurons in layer II and upper III of area 18 were labelled from GABA injection radially beneath in layer VI, providing evidence for earlier suggestions that in the monkey's visual cortex the cells in the upper layers which project radially and accumulate 3H-GABA are aspiny non-pyramidal cells. The results indicate the existence of different types of putative GABA-ergic interneurons.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Experimental Brain Research. - 53 (1984), p. 295-303. -
További szerzők:Kisvárday Zoltán (1957-) (biológus, neurobiológus) Freund Tamás F. Cowey, Alan
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11.

001-es BibID:BIBFORM033391
035-os BibID:PMID:6199225 WOS:A1984SF96200005
Első szerző:Somogyi Péter
Cím:Different types of 3H-GABA accumulating neurons in the visual cortex of the rat : characterization by combined autoradiography and Golgi impregnation / P. Somogyi, T. F. Freund, Z. F. Kisvárday
Dátum:1984
ISSN:0014-4819
Megjegyzések:Labelled neurons were identified by autoradiography following tangential intracortical injection of [3H]-gamma-aminobutyrate (GABA). The addition of cis-1,3-aminocyclohexane carboxylic acid to the GABA solution prevented perikaryal labelling. Labelled neurons were found in each injected layer and in addition they were always present directly above the injection track. The labelling of neurons in layer II, and upper III, following injections in layers V. and VI. can be explained by retrograde axonal transport and indicates that some GABA-ergic neurons project vertically. Ninety neurons of different types were Golgi impregnated and examined for selective [3H]-GABA uptake. Sixteen of these were labelled. On the basis of dendritic characteristics they were classified as aspiny multipolar neurons with small, medium or large dendritic fields, sparsely spiny multipolar neurons and one neuron was a bipolar cell. Thus Golgi impregnation of their processes reveals that cortical GABA-ergic neurons are a heterogeneous population. A [3H]-GABA accumulating, aspiny neuron with profoundly branching, "bushy" dendrites and locally arborizing axon in layer VI, was studied in the electron microscope. Its fine structural characteristics were similar to those of other identified non-pyramidal neurons. The existence of several types of cortical GABA-ergic neurons differing in their synaptic connections is discussed.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Experimental Brain Research. - 54 : 1 (1984), p. 45-56. -
További szerzők:Freund Tamás F. Kisvárday Zoltán (1957-) (biológus, neurobiológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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12.

001-es BibID:BIBFORM104305
035-os BibID:(scopus)85130828924 (wos)000801111100001
Első szerző:Talapka Petra (Biológus)
Cím:Application of the mirror technique for block-face scanning electron microscopy / Talapka Petra, Bába Bence Béla, Mészár Zoltán, Kisvárday Réka Eszter, Kocsis Zsolt, Srivastava Mohit, Kisvárday Zoltán
Dátum:2022
ISSN:1863-2653 1863-2661
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Brain Structure & Function. - 227 : 6 (2022), p. 1933-1947. -
További szerzők:Bába Bence Béla Mészár Zoltán Mihály (1977-) (agrármérnök) Kisvárday Réka Eszter Kocsis Zsolt (1987-) (orvos) Srivastava, Mohit Kisvárday Zoltán (1957-) (biológus, neurobiológus)
Pályázati támogatás:Open Access Funding
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Intézményi repozitóriumban (DEA) tárolt változat
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